CAS 267668-71-3

trans-Abacavir Dihydrochloride

Produit contrôlé

CAS : 267668-71-3, 783292-37-5

Applications trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formule : C₁₄H₁₈N₆O·2HCl

Couleur et forme : Neat

Masse moléculaire : 359.25

Ref: TR-A104995

(1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol Hydrochloride

Produit contrôlé

CAS : 267668-71-3

Formule : C₁₄H₁₈N₆O·ClH

Couleur et forme : Neat

Masse moléculaire : 322.793

Ref: TR-A634415

trans-Abacavir dihydrochloride

CAS : 267668-71-3

trans-Abacavir dihydrochloride is a synthetic compound classified as a nucleoside analog. It is derived from chemical synthesis and serves as a prodrug that is metabolized in the body to its active form, carbovir triphosphate. Its primary mode of action involves the inhibition of the HIV-1 reverse transcriptase enzyme. This inhibition is achieved through the incorporation of the active metabolite into viral DNA, resulting in chain termination and preventing viral replication.

Formule : C₁₄H₁₈N₆O·2HCl

Degré de pureté : Min. 95%

Masse moléculaire : 359.25 g/mol

Ref: 3D-NA16496