CAS 26780-50-7

Poly-(DL)-lactide-co-glycolide

Description :

Poly-(DL)-lactide-co-glycolide (PLGA) est un copolymère biodégradable dérivé de l'acide lactique et de l'acide glycolique, couramment utilisé dans des applications biomédicales telles que les systèmes de délivrance de médicaments et l'ingénierie tissulaire. Sa structure chimique se compose d'unités répétitives d'acide lactique et d'acide glycolique, qui peuvent être variées en proportion pour adapter les propriétés du polymère. Le PLGA se caractérise par sa biocompatibilité, sa biodégradabilité et sa capacité à former des microsphères ou des films, ce qui le rend adapté aux formulations à libération contrôlée. Le taux de dégradation du PLGA peut être ajusté en modifiant le rapport lactide-glycolide, influençant ses propriétés mécaniques et sa cinétique de libération. De plus, le PLGA est soluble dans des solvants organiques tels que le chloroforme et le dichlorométhane, mais insoluble dans l'eau, ce qui est avantageux pour diverses techniques de formulation. Ses applications s'étendent au-delà des produits pharmaceutiques pour inclure des sutures, des échafaudages pour la régénération des tissus et d'autres dispositifs médicaux. Dans l'ensemble, le PLGA est un polymère polyvalent qui joue un rôle significatif dans l'avancement de la délivrance de médicaments et de la médecine régénérative.

Formule : (C₆H₈O₄·C₄H₄O₄)x

InChI : InChI=1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

Code InChI : InChIKey=LCSKNASZPVZHEG-UHFFFAOYSA-N

SMILES : O=C1COC(=O)CO1.CC1C(=O)OC(C)C(=O)O1

Synonymes :

• 5050Dl2A
• Atrigel
• Medisorb
• OsteoScaf
• Poly(D,L-lactide-co-glycolide)
• Poly(DL-lactide-co-glycolide)
• Poly(glycolide-co-lactide)
• Poly(glycolide-lactide)
• Poly(lactide-co-glycolide)
• Poly(lactide-glycolide)
• Poly[(rac-lactide)-co-glycolide]
• Polygalactin
• Polyglactin
• Vicryl
• Glycolide-lactide polymer
• RESOMER RG 503 H
• 1,4-dioxane-2,5-dione - 3,6-dimethyl-1,4-dioxane-2,5-dione (1:1)
• 1,4-Dioxane-2,5-dione, polymer with 3,6-dimethyl-1,4-dioxane-2,5-dione
• p-Dioxane-2,5-dione, polyester with 3,6-dimethyl-p-dioxane-2,5-dione
• 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, polymer with 1,4-dioxane-2,5-dione

PLG 50:50 DLLG 5A (Poly(DL-lactide-co-glycolide) acid terminated (50:50))

CAS : 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formule : HC₆H₈O₄nC₄H₄O₄nOH

Couleur et forme : White Powder

Masse moléculaire : 54.000-69.000 Da

Ref: 45-1800105

PLG 75:25 DLLG 10A (Poly(DL-lactide-co-glycolide) acid terminated (75:25))

CAS : 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formule : HC₆H₈O₄nC₄H₄O₄mOH

Ref: 45-1800094

1,4-Dioxane-2,5-dione, polymer with 3,6-dimethyl-1,4-dioxane-2,5-dione

CAS : 26780-50-7

Formule : C₁₀H₁₂O₈

Couleur et forme : Solid

Masse moléculaire : 260.1975

Ref: IN-DA00BE6G

Poly(Dl-Lactide-Glycolide)

CAS : 26780-50-7

Poly(Dl-Lactide-Glycolide)

Degré de pureté : Mw 38000-54000

Ref: 54-OR1014706

Poly(Dl-Lactide-Glycolide)

CAS : 26780-50-7

Poly(Dl-Lactide-Glycolide)

Degré de pureté : Mw 24000-38000

Ref: 54-OR1014705

Poly(Dl-Lactide-Glycolide)

CAS : 26780-50-7

Poly(Dl-Lactide-Glycolide)

Degré de pureté : acid terminated,lactide:glycolide 50:50,Mw 7000-17

Ref: 54-OR1014704

Poly(D,L-lactide-co-glycolide), lactide: glycolide (85:15), average MW 50000 to 75000

CAS : 26780-50-7

Poly(D,L-lactide-co-glycolide) is a synthetic polymer that is used for subcutaneous implantation. It is used to treat incisional hernias and rectoceles in women. Poly(D,L-lactide-co-glycolide) can be implanted in tissues where the natural tissue has been removed or damaged. This polymer has been shown to reduce postoperative pain and improve the quality of life after surgery. Poly(D,L-lactide-co-glycolide) has also been shown to induce neuronal death in rats with experimental spinal cord injury when injected into the injured area. The polymer was injected at two different doses (5% and 10%) and induced significant neuronal death at both doses. Histological analysis showed that the tissue around the injection site had a moderate number of macrophages, but few microglia cells were observed. The presence of macrophages suggests that inflammation may have

Degré de pureté : 10 To 20%

Ref: 3D-FP168169

Poly(D,L-lactide-co-glycolide);lactide:glycolide (50:50), MW 54000-69000Da

CAS : 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biocompatible polymer that has been shown to be resistant to bacterial infections. It is a multivariate logistic regression analysis that shows the material's resistance to growth factor-β1 and neuronal death. The polymer has a low carcinogenic potential and toxicity studies have shown it is safe for use in humans. This polymer has been used in an experimental model of chronic oral toxicity and was shown to be biocompatible with human serum.

Formule : (C₆H₈O₄·C₄H₄O₄)x

Degré de pureté : Min. 95%

Couleur et forme : Powder

Ref: 3D-FP180578

Poly(D,L-lactide-co-glycolide - lactide:glycolide (50:50), average MW 7000-17000Da

CAS : 26780-50-7

Poly(D,L-lactide-co-glycolide - lactide:glycolide (50:50), average MW 7000-17000Da (PLGA) is a biocompatible polymer that has been shown to have high resistance to infectious diseases and the potential for use in biomedical applications. The polymer is often used as a drug carrier molecule and has been shown to inhibit the growth of human breast cancer cells. It also has been shown to inhibit neuronal death. PLGA stimulates the production of basic fibroblast growth factor (bFGF) which may promote wound healing and tissue regeneration. PLGA is also used in radiation therapy because it does not produce any harmful byproducts when irradiated with ionizing radiation. Toxicity studies have found that PLGA does not produce any toxicity when irradiated with ionizing radiation as well as untreated controls.

Degré de pureté : Min. 95%

Couleur et forme : Powder

Ref: 3D-FP180577

Poly(D,L-lactide-co-glycolide), lactide: glycolide (50:50), average MW 10000 to 15000

CAS : 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biodegradable polymer with a low melting point. It has been used in the form of sutures for surgical procedures and has also been shown to be effective against staphylococcus. Poly(D,L-lactide-co-glycolide) also has an effect on neuronal death and incisional wound healing. The polymer can be degraded by hydrolysis or enzymatic cleavage and is therefore not suitable as an implant material. This material is used in the form of films for drug delivery systems as well as in surgical meshes for hernia repair, abdominal wall hernias, and rectocele repair.

Formule : (C₆H₈O₄•C₄H₄O₄)x

Degré de pureté : Min. 95%

Ref: 3D-FP165618

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (90:10), average MW 10000 to 15000

CAS : 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biodegradable polymer that is used in the manufacture of sutures. It is made from the monomers L-lactide and glycolide and has an average molecular weight of 10,000 to 15,000 Daltons. Poly(D,L-lactide-co-glycolide) can be sterilized by autoclaving or gamma irradiation. The polymerization process does not produce any toxic byproducts. Polymers are soluble in solvents such as acetic acid or alcohols. They are also resistant to degradation by enzymes or bacteria. This polymer is used in the manufacturing of sutures because it has good adhesive properties and is more water resistant than other polymers. Poly(D,L-lactide-co-glycolide) can be used as an ophthalmic device because it is transparent and biocompatible with

Formule : C₃H₄O₂xC₂H₂O₂y

Degré de pureté : Min. 95%

Ref: 3D-FP165619

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (75:25), average MW 10000 to 15000

CAS : 26780-50-7

Poly (DL-lactide-co-glycolide) is a biodegradable polymer that is used in the manufacture of medical devices. It is made from lactic acid and glycolic acid. Poly (DL-lactide-co-glycolide) can degrade by hydrolysis to produce lactic acid and glycolic acid, which are both naturally occurring substances in the body. This polymer has been shown to be effective in treating staphylococcal infections, such as rectoceles. A predictive factor for treatment success with poly (DL-lactide-co-glycolide) is the morphology of the rectocele before surgery. In this study, multivariate logistic regression was used to analyze preoperative factors that predicted treatment success with poly (DL-lactide-co-glycolide). The results showed that women who had an incisional rectocele were more likely to have a successful outcome when treated

Formule : C₃H₄O₂xC₂H₂O₂y

Degré de pureté : Min. 95%

Ref: 3D-FP165617

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (75:25), average MW 50000 to 75000

CAS : 26780-50-7

Poly (D,L-lactide-co-glycolide) is a synthetic polymer that consists of 75% lactide and 25% glycolide. It has been used in the treatment of incisional hernia, which is a type of hernia that occurs when an organ protrudes through an incision made in the abdominal wall. Poly (D,L-lactide-co-glycolide) has also been used to prevent neuronal death in experimental animals. Histological analysis of the subcutaneous tissue showed significantly less neuronal death with poly (D,L-lactide-co-glycolide). This polymer has also been shown to be effective for women with rectocele and was found to be safe for use in this population. Poly (D,L-lactide-co-glycolide) is a synthetic polymer consisting primarily of 75% lactides and 25% glycolides. This polymer has been used as an

Formule : C₃H₄O₂xC₂H₂O₂y

Degré de pureté : Min. 95%

Couleur et forme : White Powder

Ref: 3D-FP45267

PLG 50:50 DLLG 3A (Poly(DL-lactide-co-glycolide) acid terminated (50:50))

CAS : 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formule : HC₆H₈O₄nC₄H₄O₄nOH

Couleur et forme : White Powder

Masse moléculaire : 24.000-38.000 Da

Ref: 45-1800102

PLG 75:25 DLLG 3A (Poly(DL-lactide-co-glycolide) acid terminated (75:25))

CAS : 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formule : HC₆H₈O₄nC₄H₄O₄mOH

Ref: 45-1800096

Poly-(DL)-lactide-co-glycolide

CAS : 26780-50-7

Formule : C₈H₁₄O₄

Masse moléculaire : 174.20

Ref: 4Z-L-159006