CAS 2768868-14-8

KRASG12C IN-15

CAS : 2768868-14-8

KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.

Formule : C₃₁H₃₂FN₃O₂

Couleur et forme : Solid

Masse moléculaire : 497.603

Ref: TM-T205541