CAS 2845188-22-7

Methanesulfonamide, N-[6-[[5-bromo-2-[[5-ethyl-2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]amino]-2,3-dihydro-1,4-benzodioxin-5-yl]-N-methyl-

Formule : C₃₃H₄₅BrN₈O₅S

Synonymes :

• Methanesulfonamide, N-[6-[[5-bromo-2-[[5-ethyl-2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]amino]-2,3-dihydro-1,4-benzodioxin-5-yl]-N-methyl-

WZH-15-125

CAS : 2845188-22-7

WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.

Formule : C₃₃H₄₅BrN₈O₅S

Couleur et forme : Solid

Masse moléculaire : 745.73

Ref: TM-T210936