CymitQuimica logo

CAS 2892688-18-3

:

Trier par
Le filtre de pureté n’est pas visible car les produits actuels ne disposent pas de données de pureté associées pour le filtrage.
1 produits concernés.
  • TKB272
    Targetmol
    + Info

    TKB272

    CAS :
    <p>TKB272 is an orally active antiviral agent that selectively targets the main protease (Mpro) of SARS-CoV-2, effectively inhibiting the infection and replication of various strains, including Omicron variants (such as XBB.1.5 and EG.5.1). It exhibits an enzyme inhibitory activity with an IC50 of 0.7 µM against SARS-CoV-2WK-521 Mpro and shows potent antiviral activity at the cellular level with an EC50 as low as 2.6 nM in HeLahACE2-TMPRSS2 cells against the BQ.1.1 strain. TKB272 also has a CC50 of 98 µM, indicating low cytotoxicity. Furthermore, it demonstrates a significant suppression of SARS-CoV-2XBB.1.5 replication in the B6.Cg-Tg(K18-hACE2)2-Prlmn/J transgenic mouse model, suggesting potential use in the research of SARS-CoV-2 infections.</p>
    Formule :C30H35F4N5O5S
    Couleur et forme :Solid
    Masse moléculaire :653.688

    Ref: TM-T206538