CAS 3025180-14-4

Microtubulin-IN-1

CAS : 3025180-14-4

Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.

Formule : C₂₅H₂₁FN₄O₃

Couleur et forme : Solid

Masse moléculaire : 444.458

Ref: TM-T206493