CAS 3033690-83-1

KRAS inhibitor-27

CAS : 3033690-83-1

KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.

Formule : C₃₁H₂₈ClF₃N₆O₃S

Couleur et forme : Solid

Masse moléculaire : 657.106

Ref: TM-T205081