CAS 3038489-48-1

PLK1-IN-13

CAS : 3038489-48-1

PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).

Formule : C₂₉H₃₉N₉O₂S

Couleur et forme : Solid

Masse moléculaire : 577.744

Ref: TM-T206596