CAS 3056647-52-7

PROTAC c-Met degrader-1

CAS : 3056647-52-7

PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.

Formule : C₄₅H₄₁FN₁₀O₅

Couleur et forme : Solid

Masse moléculaire : 820.87

Ref: TM-T201057