CAS 3081383-46-9

(S)-dHTC1

CAS : 3081383-46-9

(S)-dHTC1 is a molecular glue degrader specifically targeting the transcriptional coactivator ENL. It exhibits high affinity binding to E3 ligase only upon formation of the ENL:(S)-dHTC1 complex, with an IC50 of 93 nM. In MV4;11 cells, (S)-dHTC1 degrades ENL with a DC50 of 26 nM. This compound can be utilized for acute myeloid leukemia research.

Formule : C₃₃H₄₀N₈O₆S

Couleur et forme : Solid

Masse moléculaire : 676.786

Ref: TM-T206969