CAS 3106-85-2

Acide N-acétylaspartylglutamique

Description :

Acide N-acétylaspartylglutamique, communément appelé NAAG, est un dipeptide naturellement présent composé des acides aminés N-acétylaspartate et glutamate. Il est classé comme un neurotransmetteur et joue un rôle significatif dans le système nerveux central, en particulier dans la modulation de la transmission synaptique et la neuroprotection. On sait que le NAAG agit sur les récepteurs métabotropiques du glutamate, influençant divers processus physiologiques, y compris la perception de la douleur et la neuroplasticité. La substance est soluble dans l'eau et présente une stabilité dans des conditions physiologiques, ce qui la rend pertinente pour la recherche en neurobiologie et les applications thérapeutiques potentielles. Son numéro CAS, 3106-85-2, est utilisé pour l'identification dans les bases de données chimiques. L'implication du NAAG dans les maladies neurodégénératives et son potentiel en tant que biomarqueur pour certaines conditions neurologiques sont des domaines de recherche en cours, soulignant son importance dans les sciences fondamentales et appliquées.

Formule : C₁₁H₁₆N₂O₈

InChI : InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

Code InChI : InChIKey=OPVPGKGADVGKTG-BQBZGAKWSA-N

SMILES : [C@@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)(CC(O)=O)NC(C)=O

Synonymes :

• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-(N-acetyl-<smallcap>L</span>-α-aspartyl)-
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-acetyl-<smallcap>L</span>-α-aspartyl-
• Ac-Asp-Glu-OH
• Acetyl-α-<span class="text-smallcaps">L</span>-aspartylglutamic acid
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl)-, <smallcap>L</span>-
• Isospaglumic Acid
• N-(N-Acetylaspartyl)glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-α-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-aspartylglutamic acid
• N-Acetylaspartylglutamic acid
• N-acetyl-D-alpha-aspartyl-L-glutamic acid
• N-acetyl-L-alpha-aspartyl-L-glutamic acid
• N-acetyl-alpha-aspartylglutamic acid
• α-Spaglumic acid
• L-Glutamic acid, N-acetyl-L-α-aspartyl-
• Glutamic acid, N-(N-acetyl-L-aspartyl)-, L-
• N-Acetyl-L-α-aspartyl-L-glutamic acid

Ac-Asp-Glu-OH

CAS : 3106-85-2

An endogenous dipeptide with high affinity for a brain glutamate receptor. NAAG is the most abundant peptide neurotransmitter in the mammalian central nervous system.

Formule : C₁₁H₁₆N₂O₈

Degré de pureté : > 99%

Couleur et forme : White Powder

Masse moléculaire : 304.26

Ref: 01-4006232

L-Glutamic acid, N-acetyl-L-α-aspartyl-

CAS : 3106-85-2

Formule : C₁₁H₁₆N₂O₈

Degré de pureté : 95%

Couleur et forme : Solid

Masse moléculaire : 304.2533

Ref: IN-DA00321K

N-Acetyl-Asp-Glu

CAS : 3106-85-2

Formule : C₁₁H₁₆N₂O₈

Degré de pureté : ≥ 95.0%

Couleur et forme : White to off-white powder

Masse moléculaire : 304.25

Ref: 7W-GL2335

Spaglumic acid

CAS : 3106-85-2

Spaglumic acid

Degré de pureté : ≥95%

Masse moléculaire : 304.25g/mol

Ref: 54-BUP14509

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

CAS : 3106-85-2

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

Degré de pureté : 95%

Masse moléculaire : 304.25g/mol

Ref: 54-OR1024085

Spaglumic acid

CAS : 3106-85-2

Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.

Formule : C₁₁H₁₆N₂O₈

Degré de pureté : 99.92%

Couleur et forme : White Powder

Masse moléculaire : 304.25

Ref: TM-TQ0285

Spaglumic Acid-d3

Produit contrôlé

CAS : 3106-85-2

Stability Hygroscopic
Applications Spaglumic Acid-d3 is the isotope labelled analogue of Spaglumic Acid, a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formule : C₁₁H₁₃D₃N₂O₈

Couleur et forme : Neat

Masse moléculaire : 307.27

Ref: TR-S679102

N-Acetyl-L-aspartyl-L-glutamic acid

CAS : 3106-85-2

N-Acetyl-L-aspartyl-L-glutamic acid is an amino acid that is used as a substrate in the biochemical assay for glutamate. It is also used to measure brain functions. NAAG is a low potency agonist of the NMDA receptor, which may contribute to neuronal death. NAAG is used as a model system to study bowel disease and eosinophil cationic protein. It has been shown to be effective in vitro against cancer cells and fungi. The structural analysis of NAAG has revealed that it contains an acidic group on its side chain, which can be detected with a pH indicator such as phenol red or bromocresol purple.

Formule : C₁₁H₁₆N₂O₈

Degré de pureté : Min. 95 Area-%

Couleur et forme : White Off-White Powder

Masse moléculaire : 304.25 g/mol

Ref: 3D-FA05316

Spaglumic Acid

Produit contrôlé

CAS : 3106-85-2

Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formule : C₁₁H₁₆N₂O₈

Couleur et forme : Neat

Masse moléculaire : 304.25

Ref: TR-S679100

Ac-Asp-Glu • H2O

CAS : 3106-85-2

Ac-Asp-Glu • H2O is a water soluble molecule that belongs to the class of inhibitors. It has been shown to inhibit the polymerase chain reaction and is used as an analytical method for detecting DNA sequences. Ac-Asp-Glu • H2O induces neuronal death in the caudate putamen, thereby causing bowel disease, by inhibiting energy metabolism. This compound also inhibits the synthesis of proteins in the hippocampus, which leads to reduced locomotor activity and eosinophil cationic protein production. Ac-Asp-Glu • H2O is acidic and its concentration–time curve shows a bell shape. The half life of this compound is six hours.

Formule : C₁₁H₁₆N₂O₈•H₂O

Degré de pureté : Min. 95%

Masse moléculaire : 322.28 g/mol

Ref: 3D-PDE-4167