CAS 337376-15-5

Icodextrine

Description :

Icodextrine est un glucide synthétique dérivé de l'hydrolyse enzymatique de l'amidon, principalement utilisé dans des applications médicales, en particulier dans les solutions de dialyse péritonéale. C'est un polymère de glucose composé de différentes longueurs de chaîne, ce qui contribue à ses propriétés uniques. Icodextrine se caractérise par sa capacité à créer un gradient osmotique, facilitant l'élimination de l'excès de liquide du corps tout en minimisant le risque de complications liées au glucose. Il est généralement présenté sous forme de solution claire et incolore et est connu pour sa biocompatibilité et sa faible immunogénicité. La substance est stable dans des conditions normales et a un poids moléculaire relativement faible, ce qui permet une absorption et une excrétion efficaces. De plus, Icodextrine a une faible valeur calorique, ce qui le rend adapté aux patients nécessitant une gestion des fluides sans apport calorique significatif. Son utilisation dans des contextes cliniques a été associée à de meilleurs résultats pour les patients en dialyse, notamment en termes d'ultrafiltration et d'équilibre des fluides. Dans l'ensemble, Icodextrine représente une avancée significative dans la gestion des patients subissant une dialyse péritonéale.

Formule : Unspecified

InChI : InChI=1/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12-,20-15-,24-14-/t23-,25-,26+,27+,30-,37-,38+,41-,45+/m1/s1

Synonymes :

• (11beta,16beta)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
• A complex polyglucopyranose produced by the enzymatic hydrolysis of corn. It is primarily composed of alpha-1,4-glocopyranose linkage with less that 10 percent alpha-1,6 linkage
• platinum
• Adept (polysaccharide)
• 1-cyano-2-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
• (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• A complex alpha-D-glycopyranan produced by the enzymatic hydrolysis of corn. It is primarily composed of (1-4)-alpha-D-glucopyrano linkage with less than 10 percent (1-6)-alpha linkage. Dextrin, having more than 85% of its molecules with molecular masses between 1640 and 45,000 with a claimed-average molecular mass of approximately 20,000
• 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol
• 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone
• 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
• (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
• N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
• azanide
• 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
• A complex polyglucopyranose produced by the enzymatic hydrolysis of corn. It is primarily composed of alpha-1,4-glocopyranose linkage with less that 10 percent alpha-1,6 linkage
• 1-{amino[(4-chlorophenyl)amino]methylidene}-2-propan-2-ylguanidine
• (11beta,16beta)-9-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
• 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
• 2-phenyl-1H-indene-1,3(2H)-dione
• 1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• Icodextrin
• 2-benzyl-4,5-dihydro-1H-imidazole
• 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
• 1-methyl-1,3-dihydro-2H-imidazole-2-thione
• methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
• (6R,7R)-7-{[amino(phenyl)acetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
• 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine
• Icodial
• 2-(diethylamino)ethyl 1,1'-bi(cyclohexyl)-1-carboxylate
• N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
• 1-(1,2-benzoxazol-3-yl)methanesulfonamide
• 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
• 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 1-methyl-3-phenylpyrrolidine-2,5-dione
• 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
• Icodextrin, sodium chloride, sodium lactate, calcium chloride
• 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
• N,N-dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
• 2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol
• 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
• ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
• (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2E)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium
• 5-[bis(2-chloroethyl)amino]pyrimidine-2,4(1H,3H)-dione
• 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one
• N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
• Adept
• 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
• N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
• Adept (polysaccharide)
• 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
• ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
• 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium
• (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (non-preferred name)
• 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
• N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
• cyclobutane-1,1-dicarboxylic acid
• (5Z,7E,22E)-9,10-secoergosta-5,7,22-trien-3-ol
• 5,5-diphenylimidazolidine-2,4-dione
• 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
• 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
• Adept
• N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
• 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
• (11beta,17beta)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(prop-1-yn-1-yl)estra-4,9-dien-3-one
• (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
• 2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate (non-preferred name)
• 2-chloro-N-(2-chloroethyl)-N-methylethanamine
• 3-ethyl-4-methyl-N-[2-(4-{[(4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
• (17beta)-estra-1,3,5(10)-triene-3,17-diol
• 5-fluoropyrimidine-2,4(1H,3H)-dione
• methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 17,21-dihydroxypregna-1,4-diene-3,11,20-trione
• 3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
• 2-[({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine
• 2-{(Z)-[5-(hydroxymethyl)-3H-indol-3-ylidene]methyl}-N'-pentylhydrazinecarboximidamide
• [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone
• 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
• 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
• 4-(dipropylsulfamoyl)benzoic acid
• 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
• Extraneal
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
• (8R)-3-(2-deoxypentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
• (4Z)-4-(3,3-dimethyltriazanylidene)-4H-imidazole-5-carboxamide
• 9-(beta-D-arabinofuranosyl)-9H-purin-6-amine hydrate (1:1)
• (1R,5R)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azoniabicyclo[3.2.1]octane
• platinum(2+) ethanedioate - cyclohexane-1,2-diamine (1:1:1)
• 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
• 4-amino-N-[2-(diethylamino)ethyl]benzamide
• N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
• 4-{[(E)-(4-chlorophenyl)(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}butanamide
• 3-ethyl-3-methylpyrrolidine-2,5-dione
• 4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
• (3S)-9,10-secocholesta-5,7,10-trien-3-ol
• 9-methyl-3-(2H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
• 2-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridine
• 4-chloro-N-(propylcarbamoyl)benzenesulfonamide
• (2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• (5alpha)-3,14-dihydroxy-17-methyl-4,5-epoxymorphinan-6-one
• N-[(1R)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
• ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
• N~2~-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline
• 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
• 6-phenylpteridine-2,4,7-triamine
• 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol
• 1-{[(1Z)-(5-nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione
• ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 4-aminohex-5-enoic acid
• 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
• (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1E)-prop-1-en-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
• 2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide
• 2-O-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-O-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-O-sulfohexopyranuronosyl-(1->4)-2-(acetylamino)-2-deoxy-6-O-sulfohexopyranose
• 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol
• methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate
• [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
• (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
• 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• 2,2'-hexane-1,6-diylbis(1-{amino[(4-chlorophenyl)amino]methylidene}guanidine)
• [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate (non-preferred name)
• (3E)-6-oxo-3-{[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazono}cyclohexa-1,4-diene-1-carboxylic acid
• 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
• propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
• N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
• 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
• 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
• (9S,12Z,14R,15R,16S,17S,18S,19S,20R,21R,22Z,24Z)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate
• 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
• 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
• (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
• (3Z)-3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide
• 2'-deoxy-5-iodouridine
• (5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one
• 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
• 4-[(3-methylphenyl)amino]-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide
• (1S)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-L-leucinate
• 2-amino-9-[(2-hydroxyethoxy)methyl]-3,9-dihydro-6H-purin-6-one
• 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
• N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
• 5-chloro-1,3-benzoxazol-2(3H)-one
• 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
• (11E)-13-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2R,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiran-2-yl}methyl)tetrahydro-2H-pyran-2-yl]-12-methyl-10-oxotridec-11-enoic acid (non-preferred name)

Icodextrin

CAS : 337376-15-5

Degré de pureté : 95%

Couleur et forme : Solid

Masse moléculaire : G/Mol

Ref: IN-DA0037O4