CAS 368874-34-4

TC14012

CAS : 368874-34-4

CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).

Formule : C₉₀H₁₄₀N₃₄O₁₉S₂

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 2066.43

Ref: TM-TP2112

TC 14012 TFA Salt

Produit contrôlé

CAS : 368874-34-4

Stability Hygroscopic
Applications TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist
References Juarez, J. G., et al.: Blood 119, 707 (2012); Gravel, S., et al.: J Biol Chem. 285, 37939 (2010)

Formule : C₉₀H₁₄₀N₃₄O₁₉S₂•C₂HF₃O₂

Couleur et forme : Neat

Masse moléculaire : 2066.42 + (114.02)

Ref: TR-T012090

TC 14012

CAS : 368874-34-4

TC 14012 is a small-molecule drug that binds to the CXCR4 receptor and blocks HIV infection. TC 14012 is an amide with a cyclic peptide, which has been shown to inhibit both cell-specific and non-cell-specific chemokine production in vitro. TC 14012 also reduces choroidal neovascularization in mice by inhibiting angiogenic factors. The pharmacokinetic properties of TC 14012 are activated by nitrogen atoms, which allow it to be taken orally, as well as being stable to hydrolysis by esterases and CYP450 enzymes. This drug has been shown to be effective against cardiac muscle cells infected with HIV and erythrocytes infected with Mycobacterium tuberculosis.

Formule : C₉₀H₁₄₀N₃₄O₁₉S₂

Degré de pureté : Min. 95%

Masse moléculaire : 2,066.43 g/mol

Ref: 3D-TPA87434