CAS 442644-28-2

JW 67

CAS : 442644-28-2

JW 67

Degré de pureté : ≥95%

Masse moléculaire : 394.38g/mol

Ref: 54-BUP03986

JW 67

CAS : 442644-28-2

JW 67 is a small molecule inhibitor of the protein β-catenin. It has been shown to inhibit the growth of cancer cells and to reduce inflammation by inhibiting the production of inflammatory cytokines such as TNF-α and IL-6. JW 67 binds to the protein β-catenin, preventing it from binding to its cellular targets and thereby causing a decrease in cell proliferation. The compound also blocks the formation of new blood vessels that are characteristic of choroidal neovascularization in patients with age-related macular degeneration. This compound is not active against other proteins that share structural similarities with β-catenin, such as Axin2, Notch1, or c-Myc.
JW 67 has been shown to be effective in treating atrial fibrillation by blocking the action of TGF-β1 on cardiac fibroblasts and cardiomyocytes, which leads to reduced fibrosis and increased contractility.

Formule : C₂₁H₁₈N₂O₆

Degré de pureté : Min. 95%

Masse moléculaire : 394.38 g/mol

Ref: 3D-SSA64428

JW 67

CAS : 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling.

Formule : C₂₁H₁₈N₂O₆

Degré de pureté : 99.02%

Couleur et forme : Solid

Masse moléculaire : 394.38

Ref: TM-T22884