CAS 489402-47-3

ML213

CAS : 489402-47-3

Formule : C₁₇H₂₃NO

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 257.3706

Ref: IN-DA00DABD

ML213

CAS : 489402-47-3

ML213

Degré de pureté : ≥98%

Masse moléculaire : 257.37g/mol

Ref: 54-BUP05860

N-Mesitylbicyclo[2.2.1]Heptane-2-Carboxamide

CAS : 489402-47-3

N-Mesitylbicyclo[2.2.1]Heptane-2-Carboxamide

Degré de pureté : 95%

Masse moléculaire : 257.37g/mol

Ref: 54-OR1025854

ML213

CAS : 489402-47-3

ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM,

Formule : C₁₇H₂₃NO

Degré de pureté : >99.99%

Couleur et forme : Solid

Masse moléculaire : 257.37

Ref: TM-T4030

N-Mesitylbicyclo[2.2.1]heptane-2-carboxamide

CAS : 489402-47-3

Formule : C₁₇H₂₃NO

Degré de pureté : 98%

Masse moléculaire : 257.377

Ref: 10-F498723

ML-213

Produit contrôlé

CAS : 489402-47-3

Applications ML-213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). ML-213 displays >80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.
References Rundfeldt, C., et al.: Eur. J. Pharmacol., 336, 243 (1997); Singh, N., et al.: Brain, 126, 2726 (2003); Munro, G., et al.: J. Med. Chem., 50, 2576 (2007); Qi, J., et al.: Eur. J. Med. Chem., 46, 934 (2011);

Formule : C₁₇H₂₃NO

Couleur et forme : Neat

Masse moléculaire : 257.371

Ref: TR-M425300

ML-213

CAS : 489402-47-3

ML-213 is a cationic, non-selective drug that is membrane hyperpolarizing. It has been shown to increase the intracellular Ca2+ concentration in cells and to inhibit the growth of human liver, bladder, and mesenteric cells. ML-213 also exhibits selective activities against human lung cancer cells in vitro. It binds to DNA polymerase, preventing transcription and replication. This drug also inhibits the activity of protein kinases by binding to their ATP binding site. The conformational properties of ML-213 have been studied using NMR spectroscopy and found to be affected by alcohol exposure.

Formule : C₁₇H₂₃NO

Degré de pureté : Min. 95%

Masse moléculaire : 257.37 g/mol

Ref: 3D-PUA40247