CAS 50-07-7
:Mitomycine C
Description :
Mitomycine C est un puissant antibiotique antitumoral dérivé de la bactérie Streptomyces caespitosus. Il est classé comme un agent alkylant, ce qui signifie qu'il interfère avec la synthèse et la fonction de l'ADN, le rendant efficace dans le traitement de divers cancers, en particulier dans les cas de tumeurs de la vessie et gastrointestinales. Le composé présente un mécanisme d'action unique en formant des liaisons croisées entre les brins d'ADN, conduisant finalement à la mort cellulaire. Mitomycine C est généralement administré par voie intraveineuse et est connu pour ses effets cytotoxiques, qui peuvent entraîner des effets secondaires significatifs, notamment une myélosuppression, des nausées et une toxicité organique potentielle. Sa structure chimique présente un groupe quinone, qui joue un rôle crucial dans sa réactivité et son activité biologique. En raison de son efficacité, Mitomycine C est souvent utilisé en combinaison avec d'autres agents chimiothérapeutiques pour améliorer les résultats thérapeutiques. Cependant, une surveillance attentive est essentielle pendant le traitement pour gérer les effets indésirables et garantir la sécurité du patient.
Formule :C15H18N4O5
InChI :InChI=1/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7?,13+,15-/m0/s1
Code InChI :InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILES :O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4)[H])[H]
Synonymes :- (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione
- (6-Amino-8A-Methoxy-5-Methyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazireno[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate
- 6-Amino-1,1A,2,8,8A,8B-Hexahydro-8-(Hydroxymethyl)-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione Carbamate (Ester)
- Ametycine
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
- Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
- Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
- MMC
- MitoExtra
- Mitocin C
- Mitomicina
- Mitomycin C
- Mitomycin C, Streptomyces caespitosus
- Mitomycine
- Mitonco
- Mitoplus
- Mitozytrex
- Mutamycin
- Mytomycin C
- Mytomycin Kyowa S
- Nsc 26980
- [(1aR,8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [(8R,8aS,8bR)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
- [1Ar-(1Aalpha,8Beta,8Aalpha,8Balpha)]-6-Amino-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-8A-Methoxy-5-Methylazirino[2',3':3,4]Pyrrolo[1,2-Alpha]Indole-4,7-Dione
- mitomycin C from streptomyces*caespitosus
- tomycin C
- azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy
- 8aalpha,8balpha))-(9ci)
- azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox
- 8balpha)]-8aalph
- azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy
- mitomycynac
- )methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,
- 7-amino-9-alpha-methoxymitosane
- AMETYCIN
- MITOMYCIN
- mitomycynac(polish)
- Voir plus de synonymes
Trier par
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17 produits concernés.
Ametycin
CAS :Formule :C15H18N4O5Degré de pureté :>98.0%(HPLC)Couleur et forme :Dark red to Dark purple to Dark blue powder to crystalMasse moléculaire :334.33Mitomycin C, 5 mg/ml in DMSO, sterile-filtered
CAS :Mitomycin C, 50-07-7, is an antibiotic and anti-tumor agent which inhibits DNA synthesis by forming DNA crosslinks. Learn more at Thermo Fisher Scientific.
Formule :C15H18N4O5Couleur et forme :LiquidMasse moléculaire :334.33Mitomycin
CAS :Antibiotics nesoiFormule :C15H18N4O5Couleur et forme :Blue Violet PowderMasse moléculaire :334.12772Mitomycin C, 4% (with sodium chloride)
CAS :Formule :C15H18N4O5Couleur et forme :Grey to blue-purple powderMasse moléculaire :334.33Mitomycin C
CAS :Formule :C15H18N4O5Degré de pureté :(HPLC) ≥ 98.0%Couleur et forme :Grey, violet or blue powderMasse moléculaire :334.33Mitomycin C
CAS :Mitomycin CFormule :C15H18N4O5Degré de pureté :By hplc: 99.1% (Typical Value in Batch COA)Couleur et forme : blue-violet solidMasse moléculaire :334.33g/molMitomycin C
CAS :Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.Formule :C15H18N4O5Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :334.37Mitomycin 100 µg/mL in Acetonitrile
CAS :Produit contrôléFormule :C15H18N4O5Couleur et forme :Single SolutionMasse moléculaire :334.33Mitomycin C
CAS :Produit contrôléStability Hygroscopic
Applications Mitomycin C is an antitumor antibiotic. It is antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),Formule :C15H18N4O5Couleur et forme :VioletMasse moléculaire :334.33Mitomycin C - Bio-X ™
CAS :Mitomycin C is a cytotoxic agent that belongs to the class of mitomycins. It has been used for the treatment of a range of cancers and for ocular surface diseases, such as the glaucoma surgery trabeculectomy. In this case it is administered to reduce post-operative scarring which could otherwise lead to failure of the procedure. Mitomycin C is an alkylating antibiotic that inhibits DNA synthesis by cross-linking the DNA double helix. Mitomycin C also stimulates the production of transforming growth factor β1 (TGF-β1) and basic fibroblast growth factor (bFGF). Clinically, mitomycin can be used both intravenously and topically, and has been studied in a range of wound healing models.Formule :C15H18N4O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :334.33 g/molMitomycin C
CAS :Chemoterapeutic agent; DNA crosslinkerFormule :C15H18N4O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :334.33 g/molMitomycin C - High Purity
CAS :Mitomycin C is a cytotoxic agent that inhibits DNA synthesis. This product is tested according to USP specification. Mitomycin C has been shown to be effective against resistant mutants and carcinoma cell lines. It also has genotoxic activity and induces statistically significant chromosome aberrations in mammalian cells. Mitomycin C is toxic to the mitochondria, which may be due to its ability to induce mitochondrial membrane potential collapse, leading to apoptosis. Mitomycin C binds to the response element in the genome, causing transcriptional repression of a number of genes involved in cell proliferation, differentiation, or apoptosis. Mitomycin C inhibits squamous carcinoma cells by binding to their DNA and preventing RNA synthesis.Formule :C15H18N4O5Degré de pureté :Cas Rn [50-07-7] M. F. C15H18N4O5Couleur et forme :PowderMasse moléculaire :334.33 g/mol
