CAS 512784-93-9

SRX246

CAS : 512784-93-9

SRX246 is a novel anxiolytic drug that is a selective, high-affinity antagonist at the serotonin 5-HT2A receptor. SRX246 had no significant binding to other serotonin receptors (5-HT1A, 5-HT2C, and 5-HT7) or dopamine receptors (D1, D2, D3). SRX246 was not metabolized in humans and had a short half-life of about 2 hours. The pharmacokinetics of SRX246 were linear over the dose range tested.
SRX246 has been shown to be effective in animal models for anxiety and depression. T98g cells are a human cell line that has been used as an experimental model for anxiety disorders. In these cells, SRX246 inhibited the firing of neurons induced by glutamate and inhibited receptor binding to glutamate receptors.

Formule : C₄₂H₄₉N₅O₅

Degré de pureté : Min. 95%

Masse moléculaire : 703.9 g/mol

Ref: 3D-MVA78493

SRX246

CAS : 512784-93-9

SRX246: potent CNS-penetrant V1a antagonist (Ki=0.3 nM), inactive at V1b/V2, negligible binding at 64 other receptor classes.

Formule : C₄₂H₄₉N₅O₅

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 703.87

Ref: TM-T16934