CAS 51798-45-9

Elastatinal

Description :

Elastatinal est un composé chimique classé comme un peptide cyclique, spécifiquement un membre des inhibiteurs d'élastase. Il est dérivé de sources naturelles, en particulier de certaines espèces de champignons. Le composé présente une activité biologique notable, principalement en tant qu'inhibiteur de l'élastase, une enzyme qui décompose l'élastine, une protéine clé des tissus conjonctifs. Cette inhibition peut avoir des implications dans divers processus physiologiques et des applications thérapeutiques potentielles, en particulier dans des conditions caractérisées par une activité excessive de l'élastase, telles que la maladie pulmonaire obstructive chronique (MPOC) et certains troubles inflammatoires. Elastatinal se caractérise par sa structure cyclique unique, qui contribue à sa stabilité et à sa spécificité de liaison à l'élastase. De plus, il a été étudié pour son rôle potentiel dans le développement de médicaments en raison de sa capacité à moduler l'activité protéolytique. Comme pour de nombreux composés bioactifs, des recherches supplémentaires sont nécessaires pour comprendre pleinement ses mécanismes d'action, sa pharmacocinétique et ses effets secondaires potentiels dans des contextes cliniques.

Formule : C₂₁H₃₆N₈O₇

InChI : InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

Code InChI : InChIKey=IJWCGVPEDDQUDE-YGJAXBLXSA-N

SMILES : [C@H](C(N[C@H](C(N[C@H](C=O)C)=O)CCC(N)=O)=O)(NC(N[C@@H](CC(C)C)C(O)=O)=O)[C@]1(NC(N)=NCC1)[H]

Synonymes :

• (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-<span class="text-smallcaps">L</span>-glutamamide
• (2S,6S,9S,12S)-9-(3-amino-3-oxopropyl)-6-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• (2S,9S)-9-(3-amino-3-oxopropyl)-6-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• 9-(3-Amino-3-Oxopropyl)-6-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-12-Methyl-2-(2-Methylpropyl)-4,7,10,13-Tetraoxo-3,5,8,11-Tetraazatridecan-1-Oic Acid (Non-Preferred Name)
• <span class="text-smallcaps">L</smallcap>-Glutamamide, <smallcap>L</span>-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N¹-(1-methyl-2-oxoethyl)-, stereoisomer
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• Elastatinal
• N~2~-[(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-2-({[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}amino)acetyl]-N~1~-[(2S)-1-oxopropan-2-yl]-L-glutamamide
• L-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-, stereoisomer

Elastatinal

CAS : 51798-45-9

Formule : C₂₁H₃₆N₈O₇

Degré de pureté : 85%

Masse moléculaire : 512.5599

Ref: IN-DA01E4MS

Elastatinal

CAS : 51798-45-9

Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.

Formule : C₂₁H₃₆N₈O₇

Couleur et forme : Yellowish Solid

Masse moléculaire : 512.56

Ref: TM-T20130

Elastatinal microbial

CAS : 51798-45-9

Formule : C₂₁H₃₆N₈O₇

Degré de pureté : ~0.64μg/ml (IC50, pH8.8, 37°C)

Couleur et forme : White to light-yellow or tan powder

Masse moléculaire : 512.60

Ref: 7W-GL1320

Elastatinal

CAS : 51798-45-9

Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and vaginal secretions. Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and

Formule : C₂₁H₃₆N₈O₇

Degré de pureté : Min. 95%

Masse moléculaire : 512.56 g/mol

Ref: 3D-IEL-4064

Elastatinal

Produit contrôlé

CAS : 51798-45-9

Applications Elastatinal is an elastase inhibitor.

Formule : C₂₁H₃₆N₈O₇

Couleur et forme : Neat

Masse moléculaire : 512.56

Ref: TR-E501008

Elastatinal

CAS : 51798-45-9

Elastatinal is a research tool that is used to activate cells by binding to a receptor on the cell surface. Elastatinal belongs to the Ligand class of compounds and has been shown to bind to various ion channels and receptors, including cell surface receptors. This ligand binds with high affinity to the α-adrenergic receptor (α-AR) and activates cells that express this receptor. It also inhibits the binding of other ligands, such as bradykinin, which may be useful in pharmacology. Elastatinal is an inhibitor of protein interactions, which can be used in Cell Biology studies.

Formule : C₂₁H₃₆N₈O₇

Degré de pureté : Min. 95%

Masse moléculaire : 512.56 g/mol

Ref: 3D-IEL-4064-V

Elastatinal

CAS : 51798-45-9

Irreversible elastase inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formule : C₂₁H₃₆N₈O₇

Masse moléculaire : 512.6

Ref: 02-J61120