CAS 52299-14-6

Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide

Description :

Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide est un substrat de peptide synthétique couramment utilisé dans les essais biochimiques, en particulier pour la détection des enzymes protéolytiques telles que les sérine protéases. Ce composé présente un groupe succinyle, qui améliore sa solubilité et sa stabilité, et un moiety de p-nitroaniline qui sert d'indicateur chromogène. Lors de la clivage enzymatique, la libération de p-nitroaniline entraîne un changement de couleur mesurable, permettant la quantification de l'activité enzymatique. La structure consiste en une séquence d'acides aminés, spécifiquement des résidus de L-alanine, contribuant à sa spécificité et à son interaction avec les enzymes cibles. Le composé est généralement soluble dans des solutions aqueuses et présente une stabilité dans des conditions de laboratoire standard. Son utilisation dans des applications de recherche et de diagnostic souligne son importance dans la compréhension de la cinétique enzymatique et des interactions protéiques. Comme pour de nombreux substrats peptidiques, il convient de faire attention aux conditions de stockage et de manipulation pour maintenir son intégrité et sa réactivité.

Formule : C₁₉H₂₅N₅O₈

InChI : InChI=1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

Code InChI : InChIKey=GVUGADOWXGKRAE-SRVKXCTJSA-N

SMILES : N(C([C@@H](NC([C@@H](NC([C@@H](NC(CCC(O)=O)=O)C)=O)C)=O)C)=O)C1=CC=C(N(=O)=O)C=C1

Synonymes :

• 3-Carboxypropionyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• 43: PN: CN101457218 PAGE: 2 claimed protein
• <span class="text-smallcaps">L</smallcap>-Alaninamide, N-(3-carboxy-1-oxopropyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-(4-nitrophenyl)-
• Chromozym ELA
• N-(3-Carboxy-1-oxopropyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-N-(4-nitrophenyl)-<smallcap>L</span>-alaninamide
• N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-L-alaninamide
• N-SUCCINYL-(L-ALA)3-p-NITROANILIDE **03-32-0009**
• N-Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• N-Succinyl-Ala-Ala-Ala-p-nitroanilide
• Suc-Ala-Ala-Ala-pNA
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine 4-nitroanilide
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl p-nitroanilide
• Succinyl-<span class="text-smallcaps">L</span>-trialanine p-nitroanilide
• N-Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide
• 3-Carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide
• L-Alaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-
• Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide

Suc-Ala-Ala-Ala-pNA

CAS : 52299-14-6

Suc-AAA-pNA, a readily soluble and sensitive substrate for human and rat neutrophil and porcine pancreatic elastases. The trialanine substrate is also hydrolyzed by proteinase K, subtilisins and thermitase as well as by astacin, a crayfish zinc-endopeptidase.

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : > 99%

Couleur et forme : Light Yellow

Masse moléculaire : 451.44

Ref: 01-4000902

SUC-ALA-ALA-ALA-PNA

CAS : 52299-14-6

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 451.4305

Ref: IN-DA00D8ZJ

Suc-AAA-pNA

CAS : 52299-14-6

Suc-AAA-pNA is a synthetic peptide substrate commonly used for protease activity assays and widely applied in biochemical experiments.

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : 99.75%

Couleur et forme : Solid

Masse moléculaire : 451.43

Ref: TM-T205938

N-Succinyl-Ala-Ala-Ala-p-Nitroanilide

CAS : 52299-14-6

N-Succinyl-Ala-Ala-Ala-p-Nitroanilide

Degré de pureté : 98%

Masse moléculaire : 451.43g/mol

Ref: 54-OR1014482

Chromozym ELA

CAS : 52299-14-6

Formule : C₁₉H₂₅N₅O₈

Masse moléculaire : 451.44

Ref: 4Z-A-248084

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide

CAS : 52299-14-6

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4 nitroanilide is a synthetic substrate that has been shown to have proteolytic activity against dextran sulfate, collagen, and sephadex g-100. It also has insecticidal activity in that it inhibits the development of larvae of the insect Drosophila melanogaster. NSLAAALAALAAN can be used as a chemotactic agent for tissue culture cells. This synthetic substrate was also found to have antiinflammatory properties and may be useful in treating chronic bronchitis or other metabolic disorders.

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 451.43 g/mol

Ref: 3D-FS46953

Suc-Ala-Ala-Ala-pNA

CAS : 52299-14-6

Suc-Ala-Ala-Ala-pNA is a protease inhibitor that is used in the treatment of metabolic disorders. It has been shown to have neurotrophic effects, which may be due to its ability to inhibit the activity of proteases, such as cathepsin B and proteinase 3. Suc-Ala-Ala-Ala-pNA has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the activity of proinflammatory cytokines such as interleukin 1β, tumor necrosis factor α, and prostaglandin E2. Suc-Ala-Ala-Ala-pNA has long term efficacy in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : Min. 95%

Masse moléculaire : 451.43 g/mol

Ref: 3D-SAA-3071

Suc-Ala-Ala-Ala-pNA

Produit contrôlé

CAS : 52299-14-6

Formule : C₁₉H₂₅N₅O₈

Couleur et forme : Neat

Masse moléculaire : 451.43

Ref: TR-S224165

Suc-Ala-Ala-Ala-pNA

CAS : 52299-14-6

Suc-Ala-Ala-Ala-pNA is a peptide that binds to the acetylcholine receptor and activates it. This peptide has been shown to have potential as a research tool for studying the pharmacology of acetylcholine receptors in vitro. It has also been used as an inhibitor of neuronal ion channels, such as potassium channels, that are involved in the transmission of nerve impulses. Suc-Ala-Ala-Ala-pNA is not suitable for use in humans because it would be broken down by proteases before it could reach its target, but this peptide has applications in cell biology and neuroscience.

Formule : C₁₉H₂₅N₅O₈

Degré de pureté : Min. 95%

Masse moléculaire : 451.43 g/mol

Ref: 3D-SAA-3071-V