CAS 526224-73-7

Huwentoxin-IV

CAS : 526224-73-7

Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.

Formule : C₁₇₄H₂₇₈N₅₂O₅₁S₆

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 4106.79

Ref: TM-TP2016

Huwentoxin IV

CAS : 526224-73-7

Huwentoxin IV is a potent analgesic that has been shown to have antinociceptive properties in animals. Huwentoxin IV blocks the voltage-gated sodium channel NaV1.8 and prevents the transmission of pain signals to the brain. This drug has also been shown to inhibit the activity of voltage-gated potassium channels KV1.3 and KV1.5, which are involved in neuronal excitability, suggesting that huwentoxin IV may have other therapeutic applications. Huwentoxin IV interacts with disulfide bonds and is an effective inhibitor of voltage-gated sodium channels, but not voltage-gated potassium channels, at low concentrations (10 μM).

Formule : C₁₇₄H₂₇₈N₅₂O₅₁S₆

Degré de pureté : Min. 95%

Masse moléculaire : 4,107 g/mol

Ref: 3D-BWA22473