CAS 58288-50-9
:Hydroxocobalamine chlorhydrate
Description :
Hydroxocobalamine chlorhydrate est une forme de vitamine B12, spécifiquement un composé de cobalamine, caractérisé par sa couleur rouge due à la présence de cobalt. C'est une vitamine soluble dans l'eau qui joue un rôle crucial dans divers processus biologiques, y compris la synthèse de l'ADN, la formation des globules rouges et la fonction neurologique. L'hydroxocobalamine est souvent utilisée dans des contextes cliniques comme traitement de la carence en vitamine B12 et comme antidote au poisoning par cyanure en raison de sa capacité à se lier aux ions cyanure, formant un complexe non toxique. Le composé est généralement administré par voie intramusculaire ou intraveineuse, et sa pharmacocinétique implique un stockage dans le foie, où il peut être libéré au besoin. Hydroxocobalamine chlorhydrate est généralement bien toléré, avec des effets secondaires rares, mais pouvant inclure des réactions allergiques ou des réactions au site d'injection. Sa stabilité et son efficacité en font un agent thérapeutique précieux tant dans la supplémentation nutritionnelle que dans la médecine d'urgence.
Formule :C62H89CoN13O15P·xClH
InChI :InChI=1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3
Code InChI :InChIKey=KEHNCSYXYMMUCO-UHFFFAOYSA-K
SMILES :[OH-][Co+3]1234[N]=5C6(C)C7[N-]1C(C(C)(C7CC(N)=O)CCC(=O)NCC(C)OP(=O)([O-])OC8C(O)C(N9C=[N]2C=%10C9=CC(C)=C(C)C%10)OC8CO)=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5C(CCC(N)=O)C6(CC(N)=O)C)C(CC(N)=O)(C)C%12CCC(N)=O)C(C)(C)C%11CCC(N)=O.Cl
Synonymes :- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN<sup>3</sup>), hydrochloride
- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN<sup>3</sup>), hydrochloride (1:?)
- Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole, hydrochloride
- Hydroxocobalamin Chloride
- Hydroxocobalamine Hydrochloride
- Vitamin B12A Hydrochloride
- hydroxocobalamin HCl
- hydroxy-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxo-ethyl)-7,12,17-tris(3-amino-3-oxo-propyl)-3-[3-[[(2R)-2-[[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy-oxido-phosphoryl]oxypropyl]amino]-3-oxo-propyl]-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-yl]cobalt(1+) hydrochloride
- Hydroxocobalamin hydrochloride
- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), hydrochloride
- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), hydrochloride (1:?)
- Voir plus de synonymes
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9 produits concernés.
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3),hydrochloride
CAS :Formule :C62H90ClCoN13O15PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1382.8161Vitamin B12a hydrochloride
CAS :<p>Vitamin B12a monohydrochloride (Hydroxocobalamin) is an essential water-soluble vitamin.a cyanide detoxifier and nutritional supplement, injection, inhalation.</p>Formule :C62H89CoN13O15P·xHClCouleur et forme :SolidHydroxocobalamin hydrochloride
CAS :Formule :C62H89CoN13O15P·HClDegré de pureté :96.0 - 102.0 %Couleur et forme :Off-white to dark red or brown crystalline powderMasse moléculaire :1382.82Hydroxocobalamin Xhydrochloride
CAS :<p>Hydroxocobalamin Xhydrochloride</p>Degré de pureté :98%Masse moléculaire :1,382.82g/molHydroxocobalamin HCl
CAS :<p>Hydroxocobalamin HCl is a vitamin that is required for the formation of coenzyme B12. It is used to treat megaloblastic anemia, pernicious anemia, and other conditions in which vitamin B12 is deficient. Hydroxocobalamin HCl also has been shown to have physiological effects, including the inhibition of enzyme activities such as nitrite reductase and sephadex g-100. This drug binds to a number of enzymes, including group P2 enzymes (e.g., nitrate reductase) and thermolytic enzymes (e.g., hydroxylases). Hydroxocobalamin HCl has a redox potential that allows it to act as a hydrogen donor in reactions with electron acceptors such as nitrite ion or oxygen. The mechanism of action of hydroxocobalamin includes its ability to reduce intramolecular hydrogen molecules, which can be transferred to other molecules in the reaction system such as</p>Formule :C62H89CoN13O15P•(HCl)xDegré de pureté :Min. 90 Area-%Couleur et forme :PowderMasse moléculaire :1,346.35 g/molHydroxocobalamin Hydrochloride (>85%)
CAS :<p>Applications Hydroxocobalamin Hydrochloride acts as a spin trap for radical polymerization in water when reduced with ascorbic acid.<br>References Ng, Y., et al.: Macromol. Res., 20, 473-476 (2012)<br></p>Formule :C62H89CoN13O15P·ClHCouleur et forme :NeatMasse moléculaire :1382.82Cyanocobalamin EP Impurity H Chloride (Hydroxocobalamin Chloride)
CAS :Formule :C62H89CoN13O15P·HClMasse moléculaire :1382.82 36.46
