CAS 618913-30-7

AZD5904

CAS : 618913-30-7

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

Formule : C₁₀H₁₂N₄O₂S

Degré de pureté : 99.89%

Couleur et forme : Solid

Masse moléculaire : 252.29

Ref: TM-T14379

Azd5904

CAS : 618913-30-7

Formule : C₁₀H₁₂N₄O₂S

Degré de pureté : 99.93%

Couleur et forme : Solid

Masse moléculaire : 252.2929

Ref: IN-DA01EOFS

(R)-3-((Tetrahydrofuran-2-Yl)Methyl)-2-Thioxo-1,2,3,9-Tetrahydro-6H-Purin-6-One

CAS : 618913-30-7

(R)-3-((Tetrahydrofuran-2-Yl)Methyl)-2-Thioxo-1,2,3,9-Tetrahydro-6H-Purin-6-One

Degré de pureté : 98%

Masse moléculaire : 252.29g/mol

Ref: 54-OR1022969

AZD5904

CAS : 618913-30-7

AZD5904

Degré de pureté : ≥98%

Masse moléculaire : 252.29g/mol

Ref: 54-BUP04827

AZD5904

CAS : 618913-30-7

AZD5904 is a specific treatment that inhibits the enzyme hypochlorous acid (HOCl) and may be used to treat inflammatory diseases. HOCl is an oxidant that can be produced by neutrophils and macrophages, which has been shown to have a role in insulin sensitivity. AZD5904 has been shown to inhibit the production of HOCl in rats with diabetes mellitus type 2 and may also be useful for the treatment of cardiac hypertrophy.
A study was conducted using Sprague-Dawley rats, which were given AZD5904. The rats were first incubated with glucose, then injected with insulin. The rats showed reduced levels of glucose after receiving AZD5904 as compared to control groups that did not receive the drug. The study concluded that AZD5904 inhibited insulin sensitivity, thereby reducing blood glucose levels in diabetic models.

Formule : C₁₀H₁₂N₄O₂S

Degré de pureté : Min. 95%

Masse moléculaire : 252.29 g/mol

Ref: 3D-TZA91330