CAS 654654-76-9

N-Desmethyl Bedaquiline-d6 (Mixture of Enantiomers)

CAS : 654654-76-9

Formule : C₃₁H₂₃D₆BrN₂O₂

Couleur et forme : White To Off-White Solid

Masse moléculaire : 547.53

Ref: 4Z-B-101009

rac-N-Desmethyl Bedaquiline

CAS : 654654-76-9

Formule : C₃₁H₂₉BrN₂O₂

Couleur et forme : Neat

Masse moléculaire : 541.48

Ref: TR-D231310

rac-N-Desmethyl bedaquiline-d6

CAS : 654654-76-9

Bedaquiline is a new drug for the treatment of drug-resistant tuberculosis. It is a prodrug that is converted to its active form in the body by esterases and glucuronidases. Bedaquiline inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. Bedaquiline has been evaluated in clinical trials with plasma concentrations of up to 12μg/L and was shown to be effective against resistant strains of tuberculosis (TB). Bedaquiline has been shown to have a pharmacokinetic profile that improves the efficacy of ethambutol, an antibiotic used for TB treatment, with less side effects than isoniazid.

Formule : C₃₁H₂₉BrN₂O₂

Degré de pureté : Min. 95%

Masse moléculaire : 541.5 g/mol

Ref: 3D-EBB65476