CAS 7103-27-7

N3-Methyl-2'-O-methyluridine

CAS : 7103-27-7

Nucleoside Derivatives - N-Methylated nucleosides, Naturally modified Ribo-nucleosides

Formule : C₁₁H₁₆N₂O₆

Couleur et forme : Solid

Masse moléculaire : 272.25

Ref: TM-TNU0374

3,2’-O-Dimethyluridine

Produit contrôlé

CAS : 7103-27-7

Formule : C₁₁H₁₆N₂O₆

Couleur et forme : White To Off-White

Masse moléculaire : 272.254

Ref: TR-D465945

N3-Methyl-2'-O-methyluridine

CAS : 7103-27-7

2'-O-methyluridine is an antiviral nucleoside that is used as a phosphoramidite in the synthesis of oligonucleotides. It has been shown to inhibit viral replication, and has been found to be effective in treating HIV-1 by inhibiting reverse transcriptase. N3-Methyl-2'-O-methyluridine also inhibits DNA synthesis and cell proliferation, and may be useful for the treatment of cancer. This modified nucleoside has been synthesized from uracil and contains a methyl group at the 3' position. The methyl group prevents 2'-O-methyluridine from being activated by cellular thymidylate synthase, which normally converts deoxyribonucleotides into ribonucleotides. This novel nucleotide has not yet been used in clinical trials but it may provide an alternative to other drugs used for cancer treatments.

Formule : C₁₁H₁₆N₂O₆

Degré de pureté : Min. 95 Area-%

Couleur et forme : White Off-White Powder

Masse moléculaire : 272.25 g/mol

Ref: 3D-NM163076