CAS 730985-86-1

DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS

CAS : 730985-86-1

Sensitive internally quenched fluorogenic (FRET) substrate for SARS main protease with a Km value of 17 µM and a kcat value of 1.9 s⁻¹.

Formule : C₉₅H₁₄₁N₂₅O₂₄S₂

Degré de pureté : 92.7%

Couleur et forme : Dark Red

Masse moléculaire : 2081.45

Ref: 01-4045664

DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS trifluoroacetate salt

CAS : 730985-86-1

DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS trifluoroacetate salt is a fluorescent substrate for the SARS coronavirus. This compound is an inhibitor of the enzyme that is the target of a drug candidate that inhibits the replication of this virus. Molecular docking studies have shown that DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS trifluoroacetate salt binds to 3clpro, which is part of the active site of the enzyme’s catalytic pocket. Inhibition activity was seen in experiments using recombinant proteins, and kinetic analysis showed this inhibitor has a Ki value of 0.7 mM.

Formule : C₉₅H₁₄₁N₂₅O₂₄S₂·C₂HF₃O₂

Degré de pureté : Min. 95 Area-%

Couleur et forme : Powder

Masse moléculaire : 2,195.47 g/mol

Ref: 3D-FD110979