CAS 74397-12-9
:Limaprost
Description :
Limaprost est un analogue synthétique des prostaglandines principalement utilisé pour ses effets vasodilatateurs, en particulier dans le traitement des maladies vasculaires périphériques et des conditions associées à un flux sanguin altéré. Il se caractérise par sa capacité à améliorer la circulation sanguine en relaxant le muscle lisse vasculaire, ce qui peut conduire à une meilleure livraison d'oxygène aux tissus. Limaprost est souvent administré sous forme de comprimés oraux ou d'injections, selon l'indication clinique. La substance présente une demi-vie relativement courte, nécessitant un dosage soigneux pour maintenir des niveaux thérapeutiques. Son mécanisme d'action implique l'activation de récepteurs spécifiques des prostaglandines, qui médiatisent diverses réponses physiologiques, y compris l'inhibition de l'agrégation plaquettaire et la modulation des processus inflammatoires. De plus, Limaprost peut avoir des effets secondaires tels que des maux de tête, des bouffées de chaleur ou des troubles gastro-intestinaux, qui doivent être surveillés pendant le traitement. Comme pour tout médicament, son utilisation doit être guidée par un professionnel de santé, en tenant compte de l'état de santé général du patient et des potentielles interactions médicamenteuses.
Formule :C22H36O5
InChI :InChI=1/C22H36O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1
Code InChI :InChIKey=OJZYRQPMEIEQFC-UAWLTFRCSA-N
SMILES :C(CCC/C=C/C(O)=O)[C@@H]1[C@@H](/C=C/[C@H](C[C@H](CCCC)C)O)[C@H](O)CC1=O
Synonymes :- (2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic acid
- (2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl}-2-heptenoic acid (non-preferred name)
- (E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid
- (E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid 17S-Methyl-w-homo-trans-D2-PGE1
- 17S,20-Dimethyl-trans-D2-PGE1
- 17S,20-Dimethyl-trans-Δ<sup>2</sup>-PGE<sub>1</sub>
- 17S-Methyl-w-homo-trans-D2-PGE1
- 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-, (2E)-
- 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)-
- 2-Heptenoicacid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-,(2E)-
- 2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid
- 9-Oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic Acid
- Limaprost
- Ono 1206
- Op 1206
- Op1206
- Prosta-2,13-dien-1-oic acid,11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
- 17α,20-dimethyl-δ2-PGE1
- n-1-oicacid
- 11ALPHA, 15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E, 13E-DIEN-1-OIC ACID
- D02722
- ,13e,15s,17s)-
- 17A,20-DIMETHYL-D2-PGE1
- 9-oxo-11-alpha,15-alpha-dihydroxy-17s,20-dimethylprosta-trans-2,trans-13-die
- (2E,11R,13E,15S,17S)-11α,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid
- 11A,15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E,13E-DIEN-1-OIC ACID
- ono1206
- (2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die
- 17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
- (2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid
- 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)-(9CI)
- 17s,20-dimethyl-trans-2,3-didehydro-pge1
- prost-2,13-dien-1-oicacid,11,15-dihydroxy-17,20-dimethyl-9-oxo-,(2e,11-alpha
- 11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid
- Voir plus de synonymes
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9 produits concernés.
Limaprost
CAS :Formule :C22H36O5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :380.5182Limaprost
CAS :Formule :C22H36O5Degré de pureté :≥ 99.0%Couleur et forme :White to off-white powderMasse moléculaire :380.52Limaprost
CAS :Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is aFormule :C22H36O5Degré de pureté :99.61% - 99.89%Couleur et forme :SolidMasse moléculaire :380.52Limaprost
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>Formule :C22H36O5Couleur et forme :NeatMasse moléculaire :380.52Limaprost
CAS :<p>Limaprost is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the group of coumarin derivatives. It is used in the treatment of diabetic neuropathy, and has also been shown to reduce blood levels of cholesterol. Limaprost can be administered orally or topically, and blocks prostaglandin synthesis by inhibiting cyclooxygenase. Limaprost is available as a tablet and injection for oral use. The drug is also used for relief of pain in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders. Limaprost is metabolized by esterases in the liver to form desacetyllimaprost (DALP), which has approximately one-third the potency of limaprost. DALP's metabolites are excreted primarily through bile into the intestine, where they are reabsorbed back into the bloodstream. They are then</p>Formule :C22H36O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :380.52 g/mol
