CymitQuimica logo

CAS 85235-11-6

:

Trier par
Le filtre de pureté n’est pas visible car les produits actuels ne disposent pas de données de pureté associées pour le filtrage.
1 produits concernés.
  • 15-deoxy-Δ12,14-Prostaglandin D2
    Targetmol
    + Info

    15-deoxy-Δ12,14-Prostaglandin D2

    CAS :
    <p>15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.</p>
    Formule :C20H30O4
    Couleur et forme :Solid
    Masse moléculaire :334.456

    Ref: TM-T84623