CAS 87096-84-2

neuromédine B

Description :

neuromédine B est un neuropeptide qui joue un rôle significatif dans divers processus physiologiques, y compris la régulation de la contraction des muscles lisses et la modulation des fonctions neuroendocrines. Il est composé d'une séquence d'acides aminés et est classé comme un membre de la famille des neuromédines, qui sont impliquées dans la neurotransmission et la signalisation au sein du système nerveux central. neuromédine B agit principalement par l'intermédiaire de récepteurs spécifiques, influençant des processus tels que la régulation de l'appétit, la réponse au stress et les fonctions reproductives. Le peptide est connu pour être impliqué dans la physiopathologie de certaines conditions, y compris l'obésité et les troubles anxieux. Sa structure comprend généralement une amidation C-terminale, qui est cruciale pour son activité biologique. neuromédine B est synthétisé dans divers tissus, y compris le cerveau et le tractus gastro-intestinal, et ses effets sont médiés par des interactions avec des récepteurs couplés aux protéines G. La recherche continue d'explorer ses applications thérapeutiques potentielles, en particulier dans le contexte des troubles métaboliques et neuropsychiatriques.

Formule : C₅₂H₇₃N₁₅O₁₂S

InChI : InChI=1/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29+,35-,36-,37?,38-,39-,40-,44-/m0/s1

Synonymes :

• H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
• (2S)-2-[(2-aminoacetyl)amino]-N-[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[2-[[(1S)-2-[[1-benzyl-2-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]amino]-2-oxo-ethyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]butanediamide

Neuromedin B

CAS : 87096-84-2

For cellular and molecular biology applications

Formule : C₅₂H₇₃N₁₅O₁₂S

Couleur et forme : Lyophilized powder

Masse moléculaire : 1132.3

Ref: 02-J66286

Neuromedin B

CAS : 87096-84-2

NMB, a bombesin-linke peptide, binds to the bombesin receptors BRS1-4. NMB is expressed in the pituitary, brain, pancreas, adrenal and gastrointestinal tract. Its expression in adipose tissue appears to be regulated by changes in energy balance. NMB could inhibit food intake and modulates stress-related behavior.

Formule : C₅₂H₇₃N₁₅O₁₂S

Degré de pureté : 97.4%

Couleur et forme : White Powder

Masse moléculaire : 1132.31

Ref: 01-4020211

Neuromedin B

CAS : 87096-84-2

Neuromedin B

Degré de pureté : ≥98%

Masse moléculaire : 1132.29g/mol

Ref: 54-BUP01758

Neuromedin B

CAS : 87096-84-2

Neuromedin B, a mammalian peptide related to bombesin, is found in the CNS and GI tract, originally purified from pig spinal cords.

Formule : C₅₂H₇₃N₁₅O₁₂S

Degré de pureté : 99.39%

Couleur et forme : Solid

Masse moléculaire : 1132.29

Ref: TM-TP1442

Neuromedin B (porcine)

CAS : 87096-84-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formule : C₅₂H₇₃N₁₅O₁₂S

Masse moléculaire : 1,132.3 g/mol

Ref: 3D-PP50044

Neuromedin C (Human, Porcine, Canine)

CAS : 87096-84-2

Neuromedin C (NMC) is a peptide that belongs to the family of neuromedin and is a potent activator of ion channels. It has been shown to be a ligand for opioid receptors, which may be due to its ability to inhibit the release of neurotransmitters such as acetylcholine and noradrenaline. Neuromedin C has also been shown to inhibit the binding of morphine-6 beta-glucuronide in rat brain synaptosomes. In addition, NMC has been reported as an inhibitor of cell proliferation and induce apoptosis in various cancer cells including colon and prostate cancers.

Formule : C₅₀H₇₃N₁₇O₁₁S

Degré de pureté : Min. 95%

Masse moléculaire : 1,120.3 g/mol

Ref: 3D-PNM-4153-V

Neuromedin B (Human, Porcine, Rat)

CAS : 87096-84-2

Neuromedin B is a neuropeptide that has been shown to activate the TRPC ion channels in mammalian cells. It also has been shown to bind to receptors and have a potent effect on cell biology, as well as being used as a research tool for studying protein interactions. Neuromedin B is found in humans, pigs, and rats, where it is expressed primarily in the brain and gastrointestinal tract. This peptide has been shown to be an inhibitor of some types of ion channels.

Formule : C₅₂H₇₃N₁₅O₁₂S

Degré de pureté : Min. 95%

Masse moléculaire : 1,132.3 g/mol

Ref: 3D-PNM-4152-V

Neuromedin B trifluoroacetate salt

CAS : 87096-84-2

Neuromedin B is a peptide hormone that is produced by the hypothalamus and regulates many physiological processes such as energy metabolism, appetite, and sleep. Neuromedin B is a member of the family of guanine nucleotide-binding proteins (G proteins) that bind to G protein-coupled receptors on the surface of cells. It has been shown to stimulate calcium release from intracellular stores in response to an increase in cytosolic Ca2+. Neuromedin B has been shown to have anti-inflammatory effects on infectious diseases such as meningitis, sepsis, and tuberculosis, which may be due to its ability to inhibit neutrophil migration. Neuromedin B also stimulates hippocampal formation activity in rats during the rotarod test, which may be due to its effects on dopamine release.

Formule : C₅₂H₇₃N₁₅O₁₂S

Degré de pureté : Min. 95%

Masse moléculaire : 1,132.3 g/mol

Ref: 3D-FN108954