CAS 875165-39-2

2-(3-(4-Bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid

CAS : 875165-39-2

2-(3-(4-Bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid

Degré de pureté : 98%

Masse moléculaire : 477.77g/mol

Ref: 54-OR1067758

TCL1

CAS : 875165-39-2

TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.

Formule : C₁₉H₁₄BrClN₄O₂S

Couleur et forme : Solid

Masse moléculaire : 477.762

Ref: TM-T206909