CAS 90954-53-3

peptide lié au gène de la calcitonine humain

Description :

Le peptide lié au gène de la calcitonine (CGRP) est un neuropeptide qui joue un rôle significatif dans divers processus physiologiques, en particulier dans le système nerveux et la régulation cardiovasculaire. Il est dérivé du gène de la calcitonine et est principalement impliqué dans la vasodilatation et la transmission des signaux de douleur. Le CGRP est composé d'une séquence d'acides aminés, ce qui en fait un peptide, et il existe sous deux isoformes : alpha et bêta, la forme alpha étant prédominante chez les humains. Le peptide est connu pour ses puissants effets vasodilatateurs, qui contribuent à son rôle dans la physiopathologie de la migraine. Le CGRP est également impliqué dans les réponses inflammatoires et a été étudié pour ses applications thérapeutiques potentielles dans des conditions telles que les migraines et d'autres troubles de la douleur. Son activité biologique est médiée par des récepteurs spécifiques, connus sous le nom de récepteurs CGRP, qui sont des récepteurs couplés aux protéines G. Le numéro CAS 90954-53-3 identifie de manière unique cette substance dans les bases de données chimiques, facilitant la recherche et le développement en pharmacologie et biochimie.

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChI : InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Synonymes :

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS : 90954-53-3

For cellular and molecular biology applications

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

Masse moléculaire : 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS : 90954-53-3

Bachem ID: 4013281.

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

Degré de pureté : 97.62%

Couleur et forme : White

Masse moléculaire : 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS : 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS : 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

Degré de pureté : Min. 95%

Masse moléculaire : 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS : 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Formule : C₁₆₃H₂₆₇N₅₁O₄₉S₂

Degré de pureté : Min. 95%

Masse moléculaire : 3,789.3 g/mol

Ref: 3D-PCG-4160-V