CAS 927635-64-1

Ethyl 2-amino-6-bromo-?-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate

CAS : 927635-64-1

Ethyl 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate is a synthetic peptide that blocks sodium and potassium channels. It has been shown to be an antagonist of the NMDA receptor, which is involved in long term potentiation. Ethyl 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran 4 acetate binds to the receptor site and prevents glutamate from binding, thereby inhibiting the activity of the channel. This agent also inhibits protein interactions and is used as a research tool for studying protein interactions. It is also an antibody inhibitor.

Formule : C₁₇H₁₇BrN₂O₅

Degré de pureté : Min. 95%

Masse moléculaire : 409.20 g/mol

Ref: 3D-CMB63564

HA-14-1

CAS : 927635-64-1

HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.

Formule : C₁₇H₁₇BrN₂O₅

Couleur et forme : Solid

Masse moléculaire : 409.2

Ref: TM-T84388