CAS 951385-68-5
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5 produits concernés.
Sildenafil-d8
CAS :Formule :C22H22D8N6O4SCouleur et forme :White To Off-White SolidMasse moléculaire :482.63Sildenafil-d8 (piperazine-d8)
CAS :Degré de pureté :99 atom % DCouleur et forme :White SolidMasse moléculaire :482.63Sildenafil-d8
CAS :Sildenafil-d8 is a deuterated compound of Sildenafil. Sildenafil has a CAS number of 139755-83-2. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).Formule :C22H22D8N6O4SCouleur et forme :SolidMasse moléculaire :482.63Sildenafil-d8
CAS :Produit contrôléApplications Sildenafil-d8 is the labeled analogue of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998)Formule :C222H8H22N6O4SCouleur et forme :White To Off-WhiteMasse moléculaire :482.63Sildenafil-d8
CAS :Produit contrôléSildenafil-d8 is a chemical that is used in medicine. It is the 8-deuterated analog of sildenafil. Sildenafil-d8 has been shown to be more potent than sildenafil in inhibiting phosphodiesterase type-5 (PDE5) and to have a longer half-life. This drug has been shown to be effective in the treatment of pulmonary hypertension, which may be due to its ability to relax smooth muscle cells. Sildenafil-d8 can also be used for the treatment of erectile dysfunction, as it inhibits PDE5, an enzyme that degrades cyclic guanosine monophosphate (cGMP). The effects of this drug are dose dependent and are enhanced by the presence of a matrix effect. This drug is extracted from methanol using liquid chromatography with UV detection at 254 nm and mass spectrometry detection at m/z=Formule :C22H22D8N6O4SDegré de pureté :Min. 95%Masse moléculaire :482.63 g/mol
