Dérivés d'acides aminés

N-Formyl-L-histidine is a competitive inhibitor of L-histidine deaminase (Ki = 4.26 mM) and also binds to histidine-tRNA synthetase (Ki = 4.6 μM).

S-Benzylglutathione acts as a competitive inhibitor of glutathionase and undergoes conversion by rat kidney microsomes into its cysteine derivatives.

<p>3,3',5'-Triiodo-D-thyronine is a thyroid hormone that is used in the treatment of hypothyroidism. It is administered by injection or by mouth. 3,3',5'-Triiodo-D-thyronine is an insoluble drug, which means it cannot be dissolved in water. This drug can be injected into the body or taken as a pill. 3,3',5'-Triiodo-D-thyronine has been shown to increase metabolic rate and may also inhibit the growth of certain types of tumors. 3,3',5'-Triiodo-D-thyronine has been used in diagnostic procedures such as iontophoresis and implanting devices to treat prostate cancer. This medication can also be used for cosmetic purposes such as skin rejuvenation and hair loss prevention. 3,3',5'-Triiodo-D-thyronine has two structural isomers: levothyroxine and</p>

Please enquire for more information about Pheromone Cymit Quimicaesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) including the price, delivery time and more detailed product information at the technical inquiry form on this page

L-Tryptophan methyl ester hydrochloride is an allylation product of L-tryptophan, which is a precursor to serotonin and melatonin. It is used in the synthesis of benzodiazepine receptor ligands and has serotonergic activity. L-Tryptophan methyl ester hydrochloride can be synthesized from L-tryptophan by amination reaction with methylamine and formaldehyde in the presence of a base. This chemical compound was also shown to have antitumour activity against MDA-MB231 breast cancer cells, which may be due to its ability to inhibit cell proliferation.

<p>Please enquire for more information about Fmoc-2,6-dichloro-L-phenylalanine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cys-Gly-3M3SH is a cationic antimicrobial peptide that has been shown to be effective against Staphylococcus aureus. Cys-Gly-3M3SH binds to the bacterial enzyme urease, which is responsible for converting urea into ammonia and carbon dioxide. The binding of this peptide prevents the hydrolysis of urea, leading to cell death by disruption of the proton motive force. Cys-Gly-3M3SH is also biotransformed by bacteria in humans and can be used as a probe for transport studies in vitro. It can also be used as a molecular probe for structural biology research, such as protein crystallization and electron microscopy studies.</p>

L-Phenylalanyl-L-threonine is a dipeptide composed of phenylalanine and threonine, which can be utilized in the synthesis of the cyclic hexapeptide [Banyascyclamide A].

(R)-2-formamido-4-methylpentanoic acid is a derivative of leucine.

<p>Phospho-L-arginine is a derivative of arginine.</p>

<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>

<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>

<p>D-allo-Threoninol is a conformational analogue of threonine. It has been shown to inhibit the growth of Escherichia coli, Bacillus subtilis, and Staphylococcus aureus in vitro. D-allo-Threoninol binds to the enzyme methionine adenosyltransferase (MAT) by forming hydrogen bonds with its amino acid side chains. This binding prevents the formation of the MAT-coenzyme A complex, inhibiting protein synthesis and cell division.</p>

<p>The peptide RVL-psi[CH2NH]FEA-Nle-amide containing a reduced peptide bond was found to be a competitive inhibitor of the HIV-1 protease (Ki = 50 nM).</p>

<p>This NPY analog is a highly potent and selective ligand for Y₁ receptors in different cell lines and tissues. It has therefore been used to detect the NPY/PYY receptor subtype distribution, e.g., in rat brain. The peptide is also active in vivo, showing an even higher potency than NPY in increasing blood pressure in anesthetized rats.</p>

<p>WFYpSPR-pNA, chromogenic substrate for Pin1, an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase), that specifically recognizes the phosphoserine-proline bonds present in mitotic phosphoproteins (kcat/Km = 20160 mM⁻¹s⁻¹).</p>

<p>This 25 residue peptide was completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibited human cathepsin B with Ki = 2.8 µM and rat cathepsin B with Ki = 2 µM.</p>

<p>Bachem ID: 4007396.</p>

<p>Bachem ID: 4099858.</p>

<p>(Leu¹³)-Motilin (human, porcine) has been shown to produce an excitory response in the chicken gastrointestinal tract with a different sensitivity from region to region. The mechanisms of action were different between the proventriculus and the intestinal segments. The motilin analog contracted the intestinal segments by direct action on the smooth muscle cells whereas in the proventriculus it caused contraction and enhancement of electrical field stimulation-induced response through an action on the intramural cholinergic neurons.</p>

<p>In contrast to the encephalitogenic rat homolog, myelin oligodendrocyte glycoprotein (35-55) (human) does not appear to be a major T-cell epitope in multiple sclerosis propably due to its lower amount of helical structure formed when dissolved in micellar sodium dodecyl sulfate, a membrane mimicking solvent.</p>

<p>CA074, a potent inhibitor specific for cathepsin B in vitro (IC₅₀= 2.24 nM for rat liver cathepsin B) and in vivo.</p>

<p>Bachem ID: 4096115.</p>

<p>Bachem ID: 4097460.</p>

<p>Main degradation product of NPY in serum and Y2/Y5 receptor agonist.</p>

<p>Cyclolinopeptide B has been isolated from the seeds of Linum usitatissimum. It showed potent immunosuppressive activity comparable with that of cyclosporin A.</p>

<p>Bachem ID: 4030725.</p>

<p>Bachem ID: 4041119.</p>

<p>Bachem ID: 4012218.</p>

<p>The TNF-α antagonist WP9QY inhibited TNF-α mediated apoptosis and exhibited an IC₅₀ of 5 µM in the binding assay. YCWSQYLCY is the smallest peptidomimetic developed to date that might be used as a lead compound for the next generation of non-peptidic inhibitors. The name WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor(I) complex designated WP9 and the introduction of the amino acids Gln and Tyr.</p>

<p>Potential impurity of exenatide.</p>

<p>Phe-CMK, inhibitor of gramicidin S synthetase 2.</p>

<p>Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.</p>

<p>The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.</p>

<p>A highly amyloidogenic region of lactoferrin.</p>

<p>Bachem ID: 4095647.</p>

<p>Bachem ID: 4011240.</p>

<p>Bachem ID: 4097932.</p>

<p>Degradation product of oxytocin.</p>

<p>Suc-AEPF-AMC, fluorogenic substrate for the peptidylprolyl isomerase Pin1.</p>

<p>Bachem ID: 4095528.</p>

<p>This biotinylated LHRH derivative has been used in a functional analysis of the LHRH receptor ligand binding.</p>

<p>Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3.0 nM. Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell.</p>

<p>Bachem ID: 4095648.</p>

<p>Chromogenic substrate for trypsin and papain.</p>

Methyl 2-(benzylamino)-3-hydroxypropanoate, catalog number T66013 and CAS number 144001-42-3, is a valuable organic compound for life sciences research.

<p>L-N-Benzylserine is a useful organic compound for research related to life sciences. The catalog number is T65056 and the CAS number is 17136-45-7.</p>

Lysyl-tyrosyl-lysine is a bioactive chemical.

Boc-His(Boc)-OH.DCHA, an amino acid derivative, has a wide range of applications in life science research.

<p>Fmoc-HoCys(ACM)-OH is an amino acid derivative and has a wide range of applications in life science related research.</p>

Fmoc-1-methyl-L-histidine is a valuable organic compound for life sciences research (Catalog No.: T66680, CAS: 202920-22-7).

Boc-D-His(trt)-OH is an amino acid derivative and has a wide range of applications in life science related research.

<p>N-Acetyl-L-alanine is the N-acetylated form of L-alanine and is a nonessential amino acid. It is an amide containing one nitrogen atom and two carbonyl groups. The nitrogen can be found in either the alpha or beta position on the amide. The biological properties of N-acetyl-L-alanine are similar to those of L-alanine, as it is used as a substrate for protein synthesis and has been shown to inhibit p21 and epidermal growth factor. The conformational properties of N-acetyl-L-alanine are different from that of L-alanine due to its changed shape, which may affect its biological activity.</p>

<p>N-Hippuryl-His-Leu hydrate is a synthetic inhibitor that binds to the active site of mitochondrial ATP synthase and blocks the synthesis of ATP. This molecule has shown an inhibitory effect on the mitochondrial membrane potential, which may be due to its inhibition of ATP synthesis. N-Hippuryl-His-Leu hydrate also inhibits hydrochloric acid and galactose induced angiotensin II formation in rat vascular tissues. It has been used as a pharmaceutical preparation for the treatment of high blood pressure, however it does not have any biological properties that are related to uronic acid or blood pressure regulation.</p>