Dérivés d'acides aminés

<p>Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.</p>

<p>The TNF-α antagonist WP9QY inhibited TNF-α mediated apoptosis and exhibited an IC₅₀ of 5 µM in the binding assay. YCWSQYLCY is the smallest peptidomimetic developed to date that might be used as a lead compound for the next generation of non-peptidic inhibitors. The name WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor(I) complex designated WP9 and the introduction of the amino acids Gln and Tyr.</p>

<p>Bachem ID: 4095647.</p>

<p>Cyclolinopeptide B has been isolated from the seeds of Linum usitatissimum. It showed potent immunosuppressive activity comparable with that of cyclosporin A.</p>

<p>Main degradation product of NPY in serum and Y2/Y5 receptor agonist.</p>

<p>Suc-AEPF-AMC, fluorogenic substrate for the peptidylprolyl isomerase Pin1.</p>

<p>Bachem ID: 4012218.</p>

<p>Bachem ID: 4041119.</p>

<p>Bachem ID: 4097460.</p>

<p>Chromogenic substrate for trypsin and papain.</p>

<p>A highly amyloidogenic region of lactoferrin.</p>

<p>In contrast to the encephalitogenic rat homolog, myelin oligodendrocyte glycoprotein (35-55) (human) does not appear to be a major T-cell epitope in multiple sclerosis propably due to its lower amount of helical structure formed when dissolved in micellar sodium dodecyl sulfate, a membrane mimicking solvent.</p>

<p>Bachem ID: 4097932.</p>

<p>The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.</p>

<p>Bachem ID: 4011240.</p>

<p>This biotinylated LHRH derivative has been used in a functional analysis of the LHRH receptor ligand binding.</p>

<p>WFYpSPR-pNA, chromogenic substrate for Pin1, an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase), that specifically recognizes the phosphoserine-proline bonds present in mitotic phosphoproteins (kcat/Km = 20160 mM⁻¹s⁻¹).</p>

<p>Bachem ID: 4099858.</p>