Bcr-Abl
Les inhibiteurs de Bcr-Abl sont des thérapies ciblées qui inhibent la protéine de fusion Bcr-Abl, formée à la suite de la translocation du chromosome Philadelphie et moteur de la leucémie myéloïde chronique (LMC). Cette protéine influence également l'angiogenèse, contribuant à la progression tumorale. Les inhibiteurs de Bcr-Abl sont cruciaux dans le traitement de la LMC et sont explorés pour leur potentiel à inhiber l'angiogenèse dans divers cancers. Chez CymitQuimica, nous offrons des inhibiteurs de Bcr-Abl de haute qualité pour soutenir vos recherches en biologie du cancer, angiogenèse et thérapies ciblées.
119 produits trouvés pour "Bcr-Abl".
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BCR-ABL-IN-5
CAS :BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.Formule :C25H21Cl2N5O2Couleur et forme :SolidMasse moléculaire :494.37BCR-ABL1-IN-1
CAS :BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.Formule :C18H12F3N3O2Couleur et forme :SolidMasse moléculaire :359.3PPY A
CAS :PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFormule :C22H20N4O2Degré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :372.42SKLB 1028
CAS :SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formule :C24H29N9Degré de pureté :99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :443.55Ref: TM-T34656
1mg52,00€5mg113,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg358,00€50mg530,00€100mg758,00€500mg1.558,00€CGP77675
CAS :CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormule :C26H29N5O2Degré de pureté :99.66%Couleur et forme :White SolidMasse moléculaire :443.54Pivanex
CAS :Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.Formule :C10H18O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :202.25DosatiLink-1
CAS :DosatiLink-1 acts as an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C69H93Cl2F2N13O17SCouleur et forme :SolidMasse moléculaire :1517.52CT-721
CAS :CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.Formule :C30H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.04BCR-ABL-IN-4
CAS :BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).Formule :C27H24ClF2N5O4Couleur et forme :SolidMasse moléculaire :555.96Risvodetinib
CAS :Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.Formule :C33H34N8O2Couleur et forme :SolidMasse moléculaire :574.68PonatiLink-1-24
CAS :Ponatinib, also known as PonatiLink-1-24, is a selective inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C101H144ClF5N12O29Couleur et forme :SolidMasse moléculaire :2120.73DosatiLink-2
CAS :DosatiLink-2 is an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C65H85Cl2F2N13O15SCouleur et forme :SolidMasse moléculaire :1429.42Pro-Dasatinib
CAS :Pro-Dasatinib (compound 2j) is an amino acid analogue of Dasatinib and serves as a potent Src/Abl kinase inhibitor. It exhibits antiproliferative activity against K652 leukemia cancer cells, with an IC50 of 0.21 nM.Formule :C25H29ClN8O2SMasse moléculaire :541.07Tyrosine kinase-IN-9
CAS :Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formule :C20H14ClN3O3Couleur et forme :SolidMasse moléculaire :379.796PP487
CAS :PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].Formule :C14H14BrN5OCouleur et forme :SolidMasse moléculaire :348.2HPK1-IN-61
CAS :HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.Formule :C23H22N4O2Couleur et forme :SolidMasse moléculaire :386.45HSN748
CAS :HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.521GLPG3312
CAS :GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formule :C23H21F2N5O3Degré de pureté :98.53%Couleur et forme :White SolidMasse moléculaire :453.44HG-7-86-01
CAS :HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).Formule :C28H21F3N6O2SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :562.57
