EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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EMI56
CAS :EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR-IN-39
CAS :EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32EMI48
CAS :EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR mutant-IN-2
CAS :EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69EGFR-IN-53
CAS :EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.34EGFR-IN-28
CAS :EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68BAY 2476568
CAS :BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49LDC0496
CAS :LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35Lavendustin C6
CAS :Lavendustin C6 is a effective tyrosine kinase inhibitor.Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42Mutated EGFR-IN-2
CAS :Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64PDZ1i
CAS :PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formule :C28H26N8O4Couleur et forme :SolidMasse moléculaire :538.56Nazartinib mesylate
CAS :Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12Mutated EGFR-IN-3
CAS :Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59Tyrphostin AG 112
CAS :Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formule :C13H8N4ODegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :236.23MS 39
CAS :MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Formule :C55H71ClFN9O7SCouleur et forme :SolidMasse moléculaire :1056.72Gefitinib N-oxide
CAS :Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9EGA
CAS :EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22DS21360717
CAS :DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45EGFR-IN-68
CAS :EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61Limertinib
CAS :Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06Ref: TM-T35897
1mg60,00€5mg130,00€1mL*10mM (DMSO)156,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€EphB1-IN-1
CAS :EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formule :C16H12Cl2N4O2Couleur et forme :SolidMasse moléculaire :363.2EGFR/HER2-IN-12
CAS :EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formule :C25H17ClN4O3SCouleur et forme :SolidMasse moléculaire :488.95SPH5030
CAS :SPH5030 is an irreversible, selective inhibitor of HER2.Formule :C31H31FN8O3Couleur et forme :SolidMasse moléculaire :582.63MTX-531
CAS :MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Formule :C22H20ClN5O2SCouleur et forme :SoildMasse moléculaire :453.94Z118332870
CAS :Z118332870 is a potent inhibitor of EGFR and BRD4.Formule :C18H18FN3O3Couleur et forme :SolidMasse moléculaire :343.35BPIQ-II (hydrochloride)
CAS :BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Formule :C15H11BrClN5Couleur et forme :SolidMasse moléculaire :376.64PF-6422899
CAS :PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Formule :C20H14ClFN4O2Couleur et forme :SolidMasse moléculaire :396.8MJ04
CAS :MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Formule :C20H16FN5Couleur et forme :SolidMasse moléculaire :345.37PF-06672131
CAS :PF-06672131 is a selective EGFR kinase inhibitor.Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.9EAI001
CAS :EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formule :C19H15N3O2SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :349.41RG 14467
CAS :RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formule :C14H14N2O3Couleur et forme :SolidMasse moléculaire :258.27RG 14921
CAS :RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formule :C11H9NO3Couleur et forme :SolidMasse moléculaire :203.19AFN941
CAS :AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR-IN-64
CAS :EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4JNJ28871063 hydrochloride
CAS :ErbB receptor family inhibitorFormule :C24H28Cl2N6O3Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :519.42HKI-357 dimaleate
CAS :HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formule :C39H37ClFN5O11Couleur et forme :SolidMasse moléculaire :806.2EGFR T790M/L858R-IN-5
CAS :EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formule :C28H31N9OMasse moléculaire :509.61(E/Z)-CP-724714
CAS :(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54Tyrphostin 51
CAS :Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formule :C13H8N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.23MS 154N
CAS :MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45Tarlox-TKI
CAS :Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74EGFR-IN-67
CAS :EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41NSC81111
CAS :NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33EGFR-IN-50
CAS :EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51NSC114126
CAS :NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81Antiproliferative agent-34
CAS :Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55EGFR-IN-89
CAS :EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64Epertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02EGFR-IN-16
CAS :EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Formule :C16H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.26DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
2mg35,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€EGFR-IN-2
CAS :EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66Nimotuzumab
CAS :Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.64 kDaBKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03Selatinib
CAS :Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Formule :C29H26ClFN4O3SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :565.06EGFR-IN-69
CAS :EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64BIBX 1382 Dihydrochloride
CAS :BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formule :C18H21Cl3FN7Couleur et forme :SolidMasse moléculaire :460.76EGFR-IN-63
CAS :EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Formule :C20H12BrN5SCouleur et forme :SolidMasse moléculaire :434.31EGFR/C797S-IN-1
CAS :EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR/HER2-IN-9
CAS :EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormule :C25H25ClFN5O4Couleur et forme :SolidMasse moléculaire :513.95EGFR-IN-54
CAS :EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51CAY10717
CAS :CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formule :C29H25F3N6O3Couleur et forme :SolidMasse moléculaire :562.54EGFR-IN-21
CAS :EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68UNC-CA359
CAS :UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78EGFR/HER2-IN-2
CAS :EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49PD 173955-Analog1
CAS :PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.Formule :C21H14Cl2N4O3Couleur et forme :SolidMasse moléculaire :441.27JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11EGFR-IN-25
CAS :EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76EGFR/HER2-IN-3
CAS :EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49EGFR-IN-9
CAS :EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53LY 456236 hydrochloride
CAS :LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77Tyrphostin A25
CAS :Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formule :C10H6N2O3Degré de pureté :98.98%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :371.23Cloperastine fendizoate
CAS :Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.26% - 99.98%Couleur et forme :SolidMasse moléculaire :486.57Ref: TM-T36644
1mL*10mM (DMSO)42,00€1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35EGFR-IN-99
CAS :EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49Falnidamol
CAS :Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formule :C18H19ClFN7Degré de pureté :98.816%Couleur et forme :SolidMasse moléculaire :387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€PKI-166
CAS :PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T16549
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Formule :C34H39ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.17EGFR-IN-1
CAS :EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.
Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58EGFR-IN-29
CAS :EGFR-IN-29 is a potent EGFR inhibitor.Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.68BGB-102
CAS :BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36MS 154
CAS :MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.Formule :C46H54ClFN8O8Couleur et forme :SolidMasse moléculaire :901.42BPIQ-I
CAS :BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2EGFR/HER2-IN-11
CAS :EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].Formule :C23H21ClF3N5O2Couleur et forme :SolidMasse moléculaire :491.89Nazartinib S-enantiomer
CAS :Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02Lifirafenib
CAS :Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormule :C25H17F3N4O3Degré de pureté :97.99% - 98%Couleur et forme :SolidMasse moléculaire :478.42Ref: TM-T22272
50mgÀ demander100mgÀ demander1mg34,00€5mg65,00€10mg92,00€1mL*10mM (DMSO)94,00€25mg180,00€HER2-IN-5
CAS :HER2-IN-5 is an effective inhibitor of orally active HER-2.Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6EGFR/HER2-IN-13
CAS :EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.Formule :C27H36N8O3Couleur et forme :SolidMasse moléculaire :520.63Simotinib
CAS :Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formule :C25H26ClFN4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :500.95PF-06459988
CAS :PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formule :C19H22ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.88
