EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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AZ14240475
AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.Formule :C23H15ClF2N6O2Couleur et forme :SolidMasse moléculaire :480.854MS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formule :C50H59ClF4N8O14Couleur et forme :SolidMasse moléculaire :1107.5Simotinib hydrochloride
CAS :Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.Formule :C25H27Cl2FN4O4Couleur et forme :SolidMasse moléculaire :537.41EP26
EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.Formule :C42H42ClFN4O5Masse moléculaire :736.28278ErbB-2-binding peptide
CAS :ErbB-2-binding peptide (HER2-binding peptide), a tumor-targeting peptide, holds potential for cancer research applications [1].Formule :C43H60N8O11Couleur et forme :SolidMasse moléculaire :864.98PROTAC EGFR degrader 10
CAS :PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.Formule :C49H65ClN10O7SCouleur et forme :SolidMasse moléculaire :973.62Anticancer agent 158
Anticancer agent 158 (compound 7c) demonstrates potent efficacy against various cancer cell lines, with IC50 values of 7.93 μM for HepG-2, 9.28 μM for MDA-MB-Couleur et forme :Odour SolidVarlitinib
CAS :Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formule :C22H19ClN6O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :466.94EGFR-IN-129
EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.Formule :C21H18N4O3SCouleur et forme :SolidMasse moléculaire :406.46EGFR kinase inhibitor 2
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting the mutations EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S. This compound shows potential in addressing acquired resistance in the treatment of non-small cell lung cancer.Formule :C39H40N6O5Masse moléculaire :672.30602Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Couleur et forme :LiquidMasse moléculaire :148.24 kDaOpadotina
Opadotina, a small-molecule anvatabart opadotin, exhibits antineoplastic activity [1].Couleur et forme :Odour SolidPROTAC EGFR degrader 3
CAS :Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Formule :C60H77N13O5SCouleur et forme :SolidMasse moléculaire :1092.4DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Couleur et forme :Odour SolidBMS-599626
CAS :BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Formule :C27H27FN8O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :530.55Gefitinib N-oxide hydrochloride
Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.Formule :C22H24ClFN4O41·5HClCouleur et forme :SolidMasse moléculaire :517.59HDS 029
CAS :HDS 029 has a wide range of applications in life science related research.Formule :C17H11ClFN5OCouleur et forme :SolidMasse moléculaire :355.76MS9449
CAS :MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.Formule :C60H76ClFN10O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1151.82HER2-IN-14
CAS :HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96Matuzumab
CAS :Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.9 kDa
