EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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Antiproliferative agent-34
CAS :Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55EGFR-IN-89
CAS :EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64Epertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02EGFR-IN-16
CAS :EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Formule :C16H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.26DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
2mg35,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€EGFR-IN-2
CAS :EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66Nimotuzumab
CAS :Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.64 kDaBKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03Selatinib
CAS :Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Formule :C29H26ClFN4O3SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :565.06EGFR-IN-69
CAS :EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64BIBX 1382 Dihydrochloride
CAS :BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formule :C18H21Cl3FN7Couleur et forme :SolidMasse moléculaire :460.76EGFR-IN-63
CAS :EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Formule :C20H12BrN5SCouleur et forme :SolidMasse moléculaire :434.31EGFR/C797S-IN-1
CAS :EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR/HER2-IN-9
CAS :EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormule :C25H25ClFN5O4Couleur et forme :SolidMasse moléculaire :513.95EGFR-IN-54
CAS :EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51CAY10717
CAS :CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formule :C29H25F3N6O3Couleur et forme :SolidMasse moléculaire :562.54EGFR-IN-21
CAS :EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68UNC-CA359
CAS :UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78EGFR/HER2-IN-2
CAS :EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49PD 173955-Analog1
CAS :PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.Formule :C21H14Cl2N4O3Couleur et forme :SolidMasse moléculaire :441.27JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11EGFR-IN-25
CAS :EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76EGFR/HER2-IN-3
CAS :EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49EGFR-IN-9
CAS :EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53LY 456236 hydrochloride
CAS :LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77Tyrphostin A25
CAS :Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formule :C10H6N2O3Degré de pureté :98.98%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :371.23Cloperastine fendizoate
CAS :Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.26% - 99.98%Couleur et forme :SolidMasse moléculaire :486.57Ref: TM-T36644
1mL*10mM (DMSO)42,00€1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35EGFR-IN-99
CAS :EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49Falnidamol
CAS :Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formule :C18H19ClFN7Degré de pureté :98.816%Couleur et forme :SolidMasse moléculaire :387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€PKI-166
CAS :PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T16549
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Formule :C34H39ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.17EGFR-IN-1
CAS :EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.
Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58EGFR-IN-29
CAS :EGFR-IN-29 is a potent EGFR inhibitor.Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.68BGB-102
CAS :BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36MS 154
CAS :MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.Formule :C46H54ClFN8O8Couleur et forme :SolidMasse moléculaire :901.42BPIQ-I
CAS :BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2EGFR/HER2-IN-11
CAS :EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].Formule :C23H21ClF3N5O2Couleur et forme :SolidMasse moléculaire :491.89Nazartinib S-enantiomer
CAS :Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02Lifirafenib
CAS :Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormule :C25H17F3N4O3Degré de pureté :97.99% - 98%Couleur et forme :SolidMasse moléculaire :478.42Ref: TM-T22272
50mgÀ demander100mgÀ demander1mg34,00€5mg65,00€10mg92,00€1mL*10mM (DMSO)94,00€25mg180,00€HER2-IN-5
CAS :HER2-IN-5 is an effective inhibitor of orally active HER-2.Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6EGFR/HER2-IN-13
CAS :EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.Formule :C27H36N8O3Couleur et forme :SolidMasse moléculaire :520.63Simotinib
CAS :Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formule :C25H26ClFN4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :500.95PF-06459988
CAS :PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formule :C19H22ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.88
