EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
590 produits trouvés pour "EGFR".
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MS 39
CAS :MS 39 is a selective EGFR PROTAC degrader. By recruiting the VHL E3 ligase to induce EGFR degradation, it effectively suppresses EGFR signaling and cell proliferation in lung cancer models, utilized in research for EGFR-mutated cancers.Formule :C55H71ClFN9O7SDegré de pureté :99.65%Couleur et forme :White SolidMasse moléculaire :1056.72Epertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
2mg34,00€5mg49,00€1mL*10mM (DMSO)52,00€10mg73,00€25mg141,00€50mg222,00€100mg356,00€200mg522,00€Gefitinib N-oxide
CAS :Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62EGFR-IN-68
CAS :EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35Anti-Human/Rat HER2 (neu) Antibody (7.16.4)
Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is a mouse-derived IgG2a, κ monoclonal antibody inhibitor that targets human or rat HER2.EGFR-IN-2
CAS :EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :Yellow SolidMasse moléculaire :551.66EGFR-IN-59
CAS :EGFR-IN-59 is a selective EGFR inhibitor; blocks autophosphorylation; inhibits PI3K/AKT signaling; NSCLC research tool.Formule :C27H23N5O4SDegré de pureté :99.32%Couleur et forme :Yellow SolidMasse moléculaire :513.57Nimotuzumab
CAS :Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :White LiquidMasse moléculaire :147.64 kDaBKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51EGFR-IN-64
CAS :EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4EMI56
CAS :EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4Tyrphostin 51
CAS :Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formule :C13H8N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.23GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03MS 154N
CAS :MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45EGA
CAS :EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22DS21360717
CAS :DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45Mutated EGFR-IN-3
CAS :Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59Mutated EGFR-IN-2
CAS :Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64Selatinib
CAS :Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Formule :C29H26ClFN4O3SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :565.06Limertinib
CAS :Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06Ref: TM-T35897
1mg60,00€5mg130,00€1mL*10mM (DMSO)156,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69EGFR mutant-IN-2
CAS :EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6EphB1-IN-1
CAS :EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formule :C16H12Cl2N4O2Couleur et forme :SolidMasse moléculaire :363.2EGFR/HER2-IN-12
CAS :EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formule :C25H17ClN4O3SCouleur et forme :SolidMasse moléculaire :488.95SPH5030
CAS :SPH5030 is an irreversible, selective inhibitor of HER2.Formule :C31H31FN8O3Couleur et forme :SolidMasse moléculaire :582.63MTX-531
CAS :MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Formule :C22H20ClN5O2SCouleur et forme :SolidMasse moléculaire :453.94Z118332870
CAS :Z118332870 is a potent inhibitor of EGFR and BRD4.Formule :C18H18FN3O3Couleur et forme :SolidMasse moléculaire :343.35BPIQ-II (hydrochloride)
CAS :BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Formule :C15H11BrClN5Couleur et forme :SolidMasse moléculaire :376.64PF-6422899
CAS :PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Formule :C20H14ClFN4O2Couleur et forme :SolidMasse moléculaire :396.8MJ04
CAS :MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Formule :C20H16FN5Couleur et forme :SolidMasse moléculaire :345.37PF-06672131
CAS :PF-06672131 is a selective EGFR kinase inhibitor.Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.9EMI48
CAS :EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR-IN-39
CAS :EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95EAI001
CAS :EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formule :C19H15N3O2SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :349.41RG 14467
CAS :RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formule :C14H14N2O3Couleur et forme :SolidMasse moléculaire :258.27PKI-166
CAS :PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T16549
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :Yellow SolidMasse moléculaire :548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :Yellow SolidMasse moléculaire :371.23Falnidamol
CAS :Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formule :C18H19ClFN7Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€LY 456236 hydrochloride
CAS :LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77EGFR-IN-9
CAS :EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.26% - 99.98%Couleur et forme :White SolidMasse moléculaire :486.57Ref: TM-T36644
1mL*10mM (DMSO)42,00€1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37Cloperastine fendizoate
CAS :Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35EGFR-IN-99
CAS :EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formule :C25H22FN7O3Degré de pureté :97.07%Couleur et forme :White SolidMasse moléculaire :487.49
