EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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JBJ-07-149
CAS :JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formule :C28H26N6O2SCouleur et forme :SolidMasse moléculaire :510.61DSPE-PEG1000-GE11
DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.Couleur et forme :Odour SolidEGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633Anticancer agent 158
Anticancer agent 158 (compound 7c) demonstrates potent efficacy against various cancer cell lines, with IC50 values of 7.93 μM for HepG-2, 9.28 μM for MDA-MB-Couleur et forme :Odour SolidTX2-120-1
CAS :TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.54Azerutamig
Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).Couleur et forme :Odour LiquidCN009543V
CAS :CN009543V is an enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways.Formule :C12H12N4O6SCouleur et forme :SolidMasse moléculaire :340.31MC-Val-Cit-PAB-Amide-TLR7 agonist 4
CAS :MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Formule :C52H72N12O11Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :1041.2EGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Formule :C42H37N7O5Couleur et forme :SolidMasse moléculaire :719.79EGFR-IN-43
EGFR-IN-43 (17c) is a potent EGFR inhibitor with ER antagonist action, tamoxifen/endoxifen+gefitinib linkage, and strong anticancer activity.Formule :C50H55ClFN5O5Couleur et forme :SolidMasse moléculaire :860.45Matuzumab
CAS :Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.9 kDaMS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formule :C50H59ClF4N8O14Couleur et forme :SolidMasse moléculaire :1107.5Dacomitinib metabolite M2
CAS :Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.Formule :C27H32ClFN6O4SCouleur et forme :SolidMasse moléculaire :591.14-Epidoxycycline
CAS :4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formule :C22H24N2O8Couleur et forme :SolidMasse moléculaire :444.44TAS2940 free base
CAS :TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.Formule :C28H30N6O2Couleur et forme :SolidMasse moléculaire :482.58EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formule :C27H20N4OCouleur et forme :SolidMasse moléculaire :416.47EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formule :C49H53ClFN5O5Couleur et forme :SolidMasse moléculaire :846.43EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formule :C17H15N7O5SCouleur et forme :SolidMasse moléculaire :429.41Necitumumab
CAS :Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Degré de pureté :97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.81 kDaEGFR-IN-15
CAS :EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.Formule :C24H25BrN6O2Couleur et forme :SolidMasse moléculaire :509.408Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderHerceptide
CAS :Herceptide (HER2-targeting peptide), a peptide that targets HER2, can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of theranostic agents.Formule :C76H110N22O23Couleur et forme :SolidMasse moléculaire :1699.82PROTAC EGFR degrader 3
CAS :Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Formule :C60H77N13O5SCouleur et forme :SolidMasse moléculaire :1092.4DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Couleur et forme :Odour SolidTyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderLyso-Monosialoganglioside GM3
CAS :Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.Formule :C41H74N2O20Couleur et forme :SolidMasse moléculaire :915.028EGFR/HER2-IN-15
EGFR/HER2-IN-15 is a dihydropyrimidine and an effective inhibitor of EGFR/HER2. It significantly suppresses EGFRwt activity with an IC50 of 37.21 nM and exhibits anticancer properties.Formule :C28H29N3O6Masse moléculaire :503.20564FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Couleur et forme :LiquidARRY-380 (analog )
CAS :ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Formule :C29H27N7O4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :569.63Ref: TM-T2518
100mgÀ demander1mg34,00€2mg47,00€5mg71,00€1mL*10mM (DMSO)92,00€10mg104,00€25mg170,00€50mg253,00€Inetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.Degré de pureté :96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Couleur et forme :Odour LiquidMasse moléculaire :145.1 kDaJAK 3 inhibitor IV
CAS :JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormule :C16H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :241.33HER2-IN-14
CAS :HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96Anticancer agent 271
Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.Couleur et forme :Odour SolidEGFR-IN-76
CAS :EGFR-IN-76 is a potent EGFR inhibitor.Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05EGFR-IN-162
EGFR-IN-162 (compound 20) is an effective EGFR inhibitor that enhances both early and late apoptosis (EGFR) as well as necrosis (necrosis). It shows potential for use in breast cancer research.Formule :C27H31N3O2Couleur et forme :SolidMasse moléculaire :429.24163Petosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Couleur et forme :Odour LiquidDSPE-PEG2000-GE11
DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.Couleur et forme :Odour SolidEGFRvIII peptide (PEPvIII)
CAS :PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.Formule :C70H111N19O24SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1634.81EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.06U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Degré de pureté :>95.0% (SDS-PAGE); 99.6% (SEC-HPLC) - >95.0% (SDS-PAGE); 99.8% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.82 kDa.EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formule :C25H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.44EGFR-IN-79
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy.Formule :C23H16ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.84IBI-334
IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.Couleur et forme :Odour LiquidSJF 1528
CAS :Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).Formule :C55H57ClFN7O8SCouleur et forme :SolidMasse moléculaire :1030.61Osimertinib dimesylate
CAS :Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formule :C30H41N7O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :691.82Mavelertinib
CAS :Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formule :C18H22FN9O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :415.42AV-412 free base
CAS :AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formule :C27H28ClFN6OCouleur et forme :SolidMasse moléculaire :507BMS-599626
CAS :Formule :C27H27FN8O3Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :530.56Tyrphostin RG 13022
CAS :Formule :C16H14N2O2Degré de pureté :>98.0%(GC)Couleur et forme :White to Yellow to Green powder to crystalMasse moléculaire :266.30WHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Yellow to Orange powder to crystalMasse moléculaire :376.21
