EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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EMI56
CAS :EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR-IN-39
CAS :EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32EMI48
CAS :EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR mutant-IN-2
CAS :EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69EGFR-IN-53
CAS :EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.34EGFR-IN-28
CAS :EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68BAY 2476568
CAS :BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49LDC0496
CAS :LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35Lavendustin C6
CAS :Lavendustin C6 is a effective tyrosine kinase inhibitor.Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42Mutated EGFR-IN-2
CAS :Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64PDZ1i
CAS :PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formule :C28H26N8O4Couleur et forme :SolidMasse moléculaire :538.56Nazartinib mesylate
CAS :Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12Mutated EGFR-IN-3
CAS :Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59Tyrphostin AG 112
CAS :Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formule :C13H8N4ODegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :236.23MS 39
CAS :MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Formule :C55H71ClFN9O7SCouleur et forme :SolidMasse moléculaire :1056.72Gefitinib N-oxide
CAS :Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9EGA
CAS :EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22DS21360717
CAS :DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45EGFR-IN-68
CAS :EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61Limertinib
CAS :Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06Ref: TM-T35897
1mg60,00€5mg130,00€1mL*10mM (DMSO)156,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€EphB1-IN-1
CAS :EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formule :C16H12Cl2N4O2Couleur et forme :SolidMasse moléculaire :363.2EGFR/HER2-IN-12
CAS :EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formule :C25H17ClN4O3SCouleur et forme :SolidMasse moléculaire :488.95SPH5030
CAS :SPH5030 is an irreversible, selective inhibitor of HER2.Formule :C31H31FN8O3Couleur et forme :SolidMasse moléculaire :582.63MTX-531
CAS :MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Formule :C22H20ClN5O2SCouleur et forme :SoildMasse moléculaire :453.94Z118332870
CAS :Z118332870 is a potent inhibitor of EGFR and BRD4.Formule :C18H18FN3O3Couleur et forme :SolidMasse moléculaire :343.35BPIQ-II (hydrochloride)
CAS :BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Formule :C15H11BrClN5Couleur et forme :SolidMasse moléculaire :376.64PF-6422899
CAS :PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Formule :C20H14ClFN4O2Couleur et forme :SolidMasse moléculaire :396.8MJ04
CAS :MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Formule :C20H16FN5Couleur et forme :SolidMasse moléculaire :345.37PF-06672131
CAS :PF-06672131 is a selective EGFR kinase inhibitor.Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.9EAI001
CAS :EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formule :C19H15N3O2SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :349.41RG 14467
CAS :RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formule :C14H14N2O3Couleur et forme :SolidMasse moléculaire :258.27RG 14921
CAS :RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formule :C11H9NO3Couleur et forme :SolidMasse moléculaire :203.19AFN941
CAS :AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR-IN-64
CAS :EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4JNJ28871063 hydrochloride
CAS :ErbB receptor family inhibitorFormule :C24H28Cl2N6O3Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :519.42HKI-357 dimaleate
CAS :HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formule :C39H37ClFN5O11Couleur et forme :SolidMasse moléculaire :806.2EGFR T790M/L858R-IN-5
CAS :EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formule :C28H31N9OMasse moléculaire :509.61(E/Z)-CP-724714
CAS :(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54Tyrphostin 51
CAS :Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formule :C13H8N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.23MS 154N
CAS :MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45Tarlox-TKI
CAS :Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74EGFR-IN-67
CAS :EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41NSC81111
CAS :NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33EGFR-IN-50
CAS :EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51NSC114126
CAS :NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81
