EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
590 produits trouvés pour "EGFR".
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4-Epidoxycycline
CAS :4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formule :C22H24N2O8Couleur et forme :SolidMasse moléculaire :444.44IGF-1R modulator 1
CAS :IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.Formule :C22H17N3O4Couleur et forme :SolidMasse moléculaire :387.39ZM323881 hydrochloride
CAS :ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formule :C22H19ClFN3O2Degré de pureté :99.43%Couleur et forme :Yellow SolidMasse moléculaire :411.86Ref: TM-T1991
1mg34,00€5mg66,00€1mL*10mM (DMSO)69,00€10mg96,00€25mg225,00€50mg369,00€100mg550,00€200mg780,00€Icotinib
CAS :Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formule :C22H21N3O4Degré de pureté :99.76% - 99.94%Couleur et forme :Pink SolidMasse moléculaire :391.42lavendustin A
CAS :lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Formule :C21H19NO6Degré de pureté :98%Couleur et forme :Yellow LiquidMasse moléculaire :381.38Icotinib Hydrochloride
CAS :Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formule :C22H22ClN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :427.88TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96Ref: TM-T6039
1mg35,00€5mg75,00€1mL*10mM (DMSO)92,00€10mg114,00€25mg205,00€50mg334,00€100mg485,00€200mg690,00€EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32EGFR-IN-53
CAS :EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.34JNJ28871063 hydrochloride
CAS :ErbB receptor family inhibitorFormule :C24H28Cl2N6O3Degré de pureté :99.78% - 99.95%Couleur et forme :Yellow SolidMasse moléculaire :519.42RG 14921
CAS :RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formule :C11H9NO3Couleur et forme :SolidMasse moléculaire :203.19EGFR-IN-55
CAS :"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42AFN941
CAS :AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR-IN-49
CAS :EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45EGFR-IN-67
CAS :EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41HKI-357 dimaleate
CAS :HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formule :C39H37ClFN5O11Couleur et forme :SolidMasse moléculaire :806.2EGFR-IN-31
CAS :EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67EGFR T790M/L858R-IN-5
CAS :EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formule :C28H31N9OCouleur et forme :SolidMasse moléculaire :509.61EGFR/HER2-IN-3
CAS :EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49EGFR-IN-25
CAS :EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76NSC81111
CAS :NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33(E/Z)-CP-724714
CAS :(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54EGFR-IN-50
CAS :EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11PD 173955-Analog1
CAS :PD 173955-Analog1 is an EGFR kinase inhibitor with predicted IC50 of 0.19 μM.Formule :C21H14Cl2N4O3Degré de pureté :97.83%Couleur et forme :White SolidMasse moléculaire :441.27EGFR/HER2-IN-2
CAS :EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49UNC-CA359
CAS :UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78CAY10717
CAS :CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formule :C29H25F3N6O3Couleur et forme :SolidMasse moléculaire :562.54EGFR/HER2-IN-9
CAS :EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormule :C25H25ClFN5O4Couleur et forme :SolidMasse moléculaire :513.95EGFR/C797S-IN-1
CAS :EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56EGFR-IN-63
CAS :EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Formule :C20H12BrN5SCouleur et forme :SolidMasse moléculaire :434.31BIBX 1382 Dihydrochloride
CAS :BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formule :C18H21Cl3FN7Couleur et forme :SolidMasse moléculaire :460.76EGFR-IN-69
CAS :EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64Tarlox-TKI
CAS :Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74EGFR-IN-54
CAS :EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51EGFR-IN-21
CAS :EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68(E/Z)-AG490
CAS :(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Formule :C17H14N2O3Couleur et forme :SolidMasse moléculaire :294.3EGFR-IN-28
CAS :EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68BAY 2476568
CAS :BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49LDC0496
CAS :LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65Lavendustin C6
CAS :Lavendustin C6 is a effective tyrosine kinase inhibitor.Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42PDZ1i
CAS :PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formule :C28H26N8O4Couleur et forme :SolidMasse moléculaire :538.56Nazartinib mesylate
CAS :Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81Antiproliferative agent-34
CAS :Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55EGFR-IN-89
CAS :EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64Tyrphostin AG 112
CAS :Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formule :C13H8N4ODegré de pureté :99.14%Couleur et forme :Yellow SolidMasse moléculaire :236.23EGFR-IN-16
CAS :EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.Formule :C16H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.26NSC114126
CAS :NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39MS 39
CAS :MS 39 is a selective EGFR PROTAC degrader. By recruiting the VHL E3 ligase to induce EGFR degradation, it effectively suppresses EGFR signaling and cell proliferation in lung cancer models, utilized in research for EGFR-mutated cancers.Formule :C55H71ClFN9O7SDegré de pureté :99.65%Couleur et forme :White SolidMasse moléculaire :1056.72
