BTK
Les inhibiteurs de la tyrosine kinase de Bruton (BTK) sont des composés qui ciblent spécifiquement et inhibent la BTK, une enzyme cruciale impliquée dans la signalisation du récepteur des cellules B et la régulation de l'angiogenèse. La BTK joue un rôle significatif dans la prolifération et la survie des cellules cancéreuses, en particulier dans les malignités hématologiques. En inhibant la BTK, ces composés peuvent perturber l'angiogenèse et la croissance tumorale, ce qui les rend précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de la BTK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
167 produits trouvés pour "BTK"
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Elsubrutinib
CAS :Elsubrutinib (ABBV-105) is an orally active, selective, and irreversible BTK inhibitor with an IC50 of 0.18 μM for the catalytic domain of BTK.Formule :C17H19N3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :297.36Ref: TM-T39130
1mg145,00€5mg250,00€10mg340,00€1mL*10mM (DMSO)356,00€25mg573,00€50mg879,00€100mg1.314,00€GDC-0834
CAS :GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse andFormule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74IBT6A hydrochloride
CAS :IBT6A hydrochloride: Ibrutinib impurity, Btk inhibitor IC50: 0.5 nM, used in dimer/adduct synthesis.Formule :C22H23ClN6OCouleur et forme :SolidMasse moléculaire :422.91Anti-BTK Antibody (3G585)
Anti-BTK Antibody (3G585) is an antibody targeting BTK. Anti-BTK Antibody (3G585) can be used in ELISA, IHC.Couleur et forme :Odour Liquid(Z)-LFM-A13
CAS :(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360Fenebrutinib
CAS :Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).
Formule :C37H44N8O4Degré de pureté :98.26% - 98.94%Couleur et forme :SolidMasse moléculaire :664.8PCI 29732
CAS :PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.Formule :C22H21N5ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :371.43CGI-1746
CAS :CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formule :C34H37N5O4Degré de pureté :97.69% - 97.88%Couleur et forme :SolidMasse moléculaire :579.69BIIB068
CAS :BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.Formule :C23H29N7O2Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :435.52Ref: TM-T9192
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg152,00€25mg264,00€50mg398,00€100mg532,00€200mg705,00€BMS-986142
CAS :BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).Formule :C32H30F2N4O4Degré de pureté :99.44% - 99.76%Couleur et forme :SolidMasse moléculaire :572.6Ref: TM-T5138
1mg105,00€2mg165,00€5mg289,00€1mL*10mM (DMSO)358,00€10mg447,00€25mg715,00€50mg964,00€100mg1.243,00€200mg1.693,00€CHMFL-BMX-078
CAS :CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.Formule :C33H35N7O6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :625.67N-piperidine Ibrutinib
CAS :N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45Tuxobertinib
CAS :Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formule :C29H29ClN6O4Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :561.03Ref: TM-T9072
2mg38,00€5mg57,00€1mL*10mM (DMSO)71,00€10mg90,00€25mg178,00€50mg334,00€100mg497,00€200mg712,00€(Rac)-IBT6A
CAS :(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.Formule :C22H22N6ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :386.45Ref: TM-T10626
1mg44,00€2mg57,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg215,00€50mg313,00€100mg439,00€200mg628,00€zanubrutinib
CAS :Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).Formule :C27H29N5O3Degré de pureté :98.42% - 99.76%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-T7584
1mg59,00€5mg137,00€1mL*10mM (DMSO)142,00€10mg236,00€25mg492,00€50mg737,00€100mg1.018,00€Ibrutinib deacryloylpiperidine
CAS :Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.Formule :C17H13N5ODegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :303.32TL-895
CAS :TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).Formule :C25H26FN5O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :447.5Ref: TM-T9705
2mg39,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg87,00€25mg172,00€50mg266,00€100mg391,00€200mg555,00€Larotinib mesylate hydrate
CAS :Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nMFormule :C26H36ClFN4O11S2Couleur et forme :SolidMasse moléculaire :699.17ONO-4059 analog
CAS :ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.Formule :C25H24N6O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :456.5Ref: TM-T6921
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg137,00€25mg264,00€50mg439,00€100mg627,00€Olmutinib
CAS :Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formule :C26H26N6O2SDegré de pureté :99.14% - 99.63%Couleur et forme :SolidMasse moléculaire :486.59Ref: TM-T6918
2mg37,00€5mg54,00€1mL*10mM (DMSO)56,00€10mg84,00€25mg130,00€50mg170,00€100mg268,00€200mg437,00€CNX-774
CAS :CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).Formule :C26H22FN7O3Degré de pureté :97.35% - 99.11%Couleur et forme :SolidMasse moléculaire :499.5Ref: TM-T2302
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)88,00€10mg119,00€25mg222,00€50mg369,00€100mg537,00€500mg1.161,00€RN486
CAS :RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).Formule :C35H35FN6O3Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :606.69Remibrutinib
CAS :Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.Formule :C27H27F2N5O3Degré de pureté :99.5% - 99.81%Couleur et forme :SolidMasse moléculaire :507.53Ref: TM-T16730
1mg92,00€5mg210,00€1mL*10mM (DMSO)235,00€10mg340,00€25mg572,00€50mg713,00€100mg1.099,00€200mg1.485,00€(S)-Sunvozertinib
CAS :(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08Branebrutinib
CAS :Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.Formule :C20H23FN4O2Degré de pureté :95.86% - 99.31%Couleur et forme :SolidMasse moléculaire :370.42Spebrutinib
CAS :Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplasticFormule :C22H22FN5O3Degré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :423.44Acalabrutinib
CAS :Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formule :C26H23N7O2Degré de pureté :98.94% - 99.64%Couleur et forme :SolidMasse moléculaire :465.51Ref: TM-T3626
5mg44,00€1mL*10mM (DMSO)48,00€10mg57,00€25mg78,00€50mg90,00€100mg144,00€200mg215,00€500mg355,00€Ibrutinib
CAS :Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.Formule :C25H24N6O2Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :440.50BTK IN-1
CAS :BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).
Formule :C19H21ClN6ODegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :384.86Avitinib
CAS :Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53Tolebrutinib
CAS :Tolebrutinib is an oral, selective BTK inhibitor, effective for MS research, with brain penetration and IC50s of 0.4/0.7 nM in cells.Formule :C26H25N5O3Degré de pureté :98.4% - 98.82%Couleur et forme :SolidMasse moléculaire :455.51Ref: TM-T9125
2mg40,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg105,00€25mg177,00€50mg264,00€100mg434,00€200mg622,00€BTK Protein, Human, Recombinant (His)
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Degré de pureté :90%Couleur et forme :Lyophilized PowderMasse moléculaire :78.3 kDa (predicted)Ibrutinib-d5
CAS :Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.Formule :C25H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53CP-547632
CAS :CP-547632 is an oral ATP-competitive inhibitor of VEGFR-2/FGF kinase with IC50s of 11/9 nM, highly selective, has antitumor activity.Formule :C20H24BrF2N5O3SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :532.4JNJ-64264681
CAS :JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63BTK inhibitor 10
CAS :BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.Formule :C25H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.48SJF620
CAS :SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).Formule :C41H44N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.84PF-06658607
CAS :PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor.Formule :C27H24N6O2Couleur et forme :SolidMasse moléculaire :464.52PF-06465469
CAS :PF-06465469, a covalent ITK and BTK inhibitor (IC₅₀ = 2 nM), suppresses CXCL12-mediated migration and decreases PD-1/LAG-3 for leukemia and lymphoma research.Formule :C30H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.63VA5 TG2 inhibitor
CAS :VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.Formule :C31H34N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.62ACP-5862
CAS :ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51CGI560
CAS :CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56BLK-IN-1
CAS :BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53DPPY
CAS :DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.Formule :C25H26ClN7O3Couleur et forme :SolidMasse moléculaire :507.97(R)-Elsubrutinib
CAS :(R)-Elsubrutinib ((R)-ABBV-105) is a Btk inhibitor and an isomer of Elsubrutinib, suitable for inflammation research.Formule :C17H19N3O2Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :297.35Ref: TM-T72653
1mg145,00€5mg250,00€10mg340,00€1mL*10mM (DMSO)462,00€25mg573,00€50mg879,00€100mg1.314,00€JAK3/BTK-IN-6
CAS :JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Formule :C21H17BF3N5O3Couleur et forme :SolidMasse moléculaire :455.2CHMFL-BTK-01
CAS :CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.Formule :C38H41N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76BI-1622
CAS :BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Formule :C26H24N10O2Couleur et forme :SolidMasse moléculaire :508.53EGFR-IN-40
CAS :EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).Formule :C23H20N6O3Couleur et forme :SolidMasse moléculaire :428.44Ibrutinib-MPEA
CAS :Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.Formule :C32H39N9O2Couleur et forme :SolidMasse moléculaire :581.71
