BTK
Les inhibiteurs de la tyrosine kinase de Bruton (BTK) sont des composés qui ciblent spécifiquement et inhibent la BTK, une enzyme cruciale impliquée dans la signalisation du récepteur des cellules B et la régulation de l'angiogenèse. La BTK joue un rôle significatif dans la prolifération et la survie des cellules cancéreuses, en particulier dans les malignités hématologiques. En inhibant la BTK, ces composés peuvent perturber l'angiogenèse et la croissance tumorale, ce qui les rend précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de la BTK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
145 produits trouvés pour "BTK"
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(Z)-LFM-A13
CAS :<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360Fenebrutinib
CAS :<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>Formule :C37H44N8O4Degré de pureté :98.26% - 98.94%Couleur et forme :SolidMasse moléculaire :664.8Ibrutinib
CAS :<p>Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.</p>Formule :C25H24N6O2Degré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :440.5PCI 29732
CAS :<p>PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.</p>Formule :C22H21N5ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :371.43Remibrutinib
CAS :<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Formule :C27H27F2N5O3Degré de pureté :99.5% - 99.81%Couleur et forme :SolidMasse moléculaire :507.53BIIB068
CAS :<p>BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.</p>Formule :C23H29N7O2Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :435.52Ibrutinib deacryloylpiperidine
CAS :<p>Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.</p>Formule :C17H13N5ODegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :303.32CHMFL-BMX-078
CAS :<p>CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.</p>Formule :C33H35N7O6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :625.67N-piperidine Ibrutinib
CAS :<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45zanubrutinib
CAS :<p>Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).</p>Formule :C27H29N5O3Degré de pureté :98.42% - 99.76%Couleur et forme :SolidMasse moléculaire :471.55BMS-986142
CAS :<p>BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).</p>Formule :C32H30F2N4O4Degré de pureté :98.7% - 99.76%Couleur et forme :SolidMasse moléculaire :572.6Acalabrutinib
CAS :<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Formule :C26H23N7O2Degré de pureté :98.94% - 99.64%Couleur et forme :SolidMasse moléculaire :465.51(Rac)-IBT6A
CAS :<p>(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Formule :C22H22N6ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :386.45TL-895
CAS :<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>Formule :C25H26FN5O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :447.5Spebrutinib
CAS :<p>Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic</p>Formule :C22H22FN5O3Degré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :423.44ONO-4059 analog
CAS :<p>ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.</p>Formule :C25H24N6O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :456.5RN486
CAS :<p>RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).</p>Formule :C35H35FN6O3Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :606.69Branebrutinib
CAS :<p>Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.</p>Formule :C20H23FN4O2Degré de pureté :95.86% - 99.31%Couleur et forme :SolidMasse moléculaire :370.42Larotinib mesylate hydrate
CAS :<p>Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM</p>Formule :C26H36ClFN4O11S2Couleur et forme :SolidMasse moléculaire :699.17CNX-774
CAS :<p>CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).</p>Formule :C26H22FN7O3Degré de pureté :97.35% - 99.11%Couleur et forme :SolidMasse moléculaire :499.5CGI-1746
CAS :<p>CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.</p>Formule :C34H37N5O4Degré de pureté :97.69% - 97.88%Couleur et forme :SolidMasse moléculaire :579.69Avitinib
CAS :<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53BTK IN-1
CAS :<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Formule :C19H21ClN6ODegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :384.86BTK Protein, Human, Recombinant (His)
<p>Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.</p>Degré de pureté :90%Couleur et forme :Lyophilized PowderMasse moléculaire :78.3 kDa (predicted)Ibrutinib-d5
CAS :<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Formule :C25H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53JAK3/BTK-IN-5
CAS :<p>JAK3/BTK-IN-5 is a potent dual inhibitor targeting JAK3 and BTK with synergistic effects, valuable for related autoimmune disease research.</p>Formule :C19H22ClN7O2Couleur et forme :SolidMasse moléculaire :415.88BLK-IN-2
CAS :<p>BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。</p>Formule :C39H41N9O3Couleur et forme :SolidMasse moléculaire :683.8EGFR-IN-40
CAS :<p>EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).</p>Formule :C23H20N6O3Couleur et forme :SolidMasse moléculaire :428.44GDC-0834 Racemate
CAS :<p>GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor</p>Formule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74BTK inhibitor 10
CAS :<p>BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.</p>Formule :C25H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.48SJF620
CAS :<p>SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).</p>Formule :C41H44N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.84Ibrutinib-MPEA
CAS :<p>Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.</p>Formule :C32H39N9O2Couleur et forme :SolidMasse moléculaire :581.71JNJ-64264681
CAS :<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63(R)-Elsubrutinib
CAS :<p>(R)-Elsubrutinib ((R)-ABBV-105), a Btk inhibitor, is used in research on immune diseases and cancer.</p>Formule :C17H19N3O2Couleur et forme :SolidMasse moléculaire :297.35DPPY
CAS :<p>DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.</p>Formule :C25H26ClN7O3Couleur et forme :SolidMasse moléculaire :507.97SB-633825
CAS :<p>SB-633825 can inhibit cancer cell growth and angiogenesis.</p>Formule :C28H25N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.58Spebrutinib besylate
CAS :<p>Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).</p>Formule :C28H28FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.62ACP-5862
CAS :<p>ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51CHMFL-BTK-01
CAS :<p>CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.</p>Formule :C38H41N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76JAK3/BTK-IN-6
CAS :<p>JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.</p>Formule :C21H17BF3N5O3Couleur et forme :SolidMasse moléculaire :455.2BI-1622
CAS :<p>BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.</p>Formule :C26H24N10O2Couleur et forme :SolidMasse moléculaire :508.53BLK-IN-1
CAS :<p>BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.</p>Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53BTK-IN-23
CAS :<p>BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.</p>Formule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55PF-06465469
CAS :<p>PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM).</p>Formule :C30H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.63VA5 TG2 inhibitor
CAS :<p>VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.</p>Formule :C31H34N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.62BTK-IN-22
CAS :<p>BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.</p>Formule :C26H26N6O2Couleur et forme :SolidMasse moléculaire :454.52CGI560
CAS :<p>CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.</p>Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56BLK degrader 1
CAS :<p>BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.</p>Formule :C32H25F3N6O2Degré de pureté :99.22% - 99.24%Couleur et forme :SolidMasse moléculaire :582.58HZ-A-005
CAS :<p>HZ-A-005 is a selective, potent, covalent inhibitor of Bruton's tyrosine kinase (BTK). HZ-A-005 significantly inhibits tumour growth in a xenograft mouse model.</p>Formule :C25H23ClN6O2Couleur et forme :SolidMasse moléculaire :474.94JS25
CAS :<p>JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.</p>Formule :C29H24N4O4SCouleur et forme :SolidMasse moléculaire :524.59
