FAK
Les inhibiteurs de la kinase d'adhésion focale (FAK) ciblent la FAK, une kinase impliquée dans l'adhésion cellulaire, la migration et l'angiogenèse. La FAK est fréquemment surexprimée dans les tumeurs et contribue à la formation de nouveaux vaisseaux sanguins qui alimentent la tumeur en nutriments. L'inhibition de la FAK peut perturber ces processus, faisant des inhibiteurs de la FAK des outils précieux en thérapie anticancéreuse et en recherche sur l'angiogenèse. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la FAK de haute qualité pour soutenir vos recherches en biologie cellulaire, cancer et angiogenèse.
72 produits trouvés pour "FAK"
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Chloropyramine hydrochloride
CAS :<p>Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.</p>Formule :C16H20ClN3·HClDegré de pureté :99.45% - 99.8%Couleur et forme :SolidMasse moléculaire :326.26ALK inhibitor 1
CAS :<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48ALK inhibitor 2
CAS :<p>ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.</p>Formule :C23H28ClN7O3SDegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :518.03Lewis y tetrasaccharide
CAS :<p>Lewis Y tetrasaccharide, a derivative of Lewis X, is an antigen linked to ovarian cancer metastasis and bad prognosis.</p>Formule :C26H45NO19Couleur et forme :SolidMasse moléculaire :675.63FAK PROTAC B5
CAS :<p>FAK PROTAC B5: a degrader with 14.9 nM IC50, strong degradation, anti-growth, good plasma stability, and fair permeability.</p>Formule :C41H43ClN10O7Couleur et forme :SolidMasse moléculaire :823.3FAK-IN-11
<p>FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.</p>Formule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6Ifebemtinib hydrochloride
<p>Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells.</p>Formule :C28H29ClF4N6O4Couleur et forme :SolidMasse moléculaire :625.01FAK-IN-15
<p>FAK-IN-15 is a highly potent focal adhesion kinase (FAK) inhibitor with antitumor activity.</p>Formule :C21H24ClN7OSDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :457.98FAK-IN-12
<p>FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM.</p>Degré de pureté :98%Couleur et forme :Odour SolidFAK-IN-14
CAS :<p>FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.</p>Formule :C21H24BrN7OSDegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :502.43FAK-IN-7
CAS :<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>Formule :C16H13N3OSDegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :295.36Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Couleur et forme :Odour SolidIfebemtinib FA
<p>BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.</p>Formule :C29H30F4N6O6Degré de pureté :98.05% - 99.73%Couleur et forme :SolidMasse moléculaire :634.58Adhesamine diTFA
CAS :<p>Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.</p>Formule :C28H32Cl2F6N8O6S2Couleur et forme :SolidMasse moléculaire :825.63MLK3-IN-1
<p>MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.</p>Formule :C20H16F6N4O2SCouleur et forme :SolidMasse moléculaire :490.422MY-1576
<p>MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.</p>Formule :C25H29ClN8O2Couleur et forme :SolidMasse moléculaire :5092119738-71-3
CAS :<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Formule :C25H29ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.99FAK-IN-9
CAS :<p>FAK-IN-9 (8f) is a potent oral FAK inhibitor, IC50 of 27.44 nM; induces TNBC cell apoptosis.</p>Formule :C36H38ClN7O8SCouleur et forme :SolidMasse moléculaire :764.25FAK-IN-1
CAS :<p>FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).</p>Formule :C24H26F3N7O4SCouleur et forme :SolidMasse moléculaire :565.57Defactinib analogue-1
CAS :<p>Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.</p>Formule :C20H20F3N5O3SCouleur et forme :SolidMasse moléculaire :467.47GSK215
CAS :<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Formule :C50H59F3N10O6SDegré de pureté :99.3%Couleur et forme :SoildMasse moléculaire :985.13VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Formule :C82H112N20O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1649.89FAK-IN-10
CAS :<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Formule :C15H10BrN3O2SDegré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :376.23FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Formule :C32H28ClN5O6Couleur et forme :SolidMasse moléculaire :613.17281Anti-PTK2 Antibody (4T687)
<p>Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidConteltinib tetrahydrochloride
<p>Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.</p>Formule :C32H49Cl4N9O3SCouleur et forme :SolidMasse moléculaire :781.667BI-3663
CAS :<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Formule :C44H42F3N7O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :917.84Y15
CAS :<p>Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,</p>Formule :C6H14Cl4N4Degré de pureté :98% - 99.32%Couleur et forme :Dark Brown CrystalsMasse moléculaire :284.01SU6656
CAS :<p>SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.</p>Formule :C19H21N3O3SDegré de pureté :98.21% - 98.73%Couleur et forme :SolidMasse moléculaire :371.45Masitinib
CAS :<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formule :C28H30N6OSDegré de pureté :97.56% - >99.99%Couleur et forme :SolidMasse moléculaire :498.64GSK2256098
CAS :<p>GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.</p>Formule :C20H23ClN6O2Degré de pureté :99.46% - 99.74%Couleur et forme :SolidMasse moléculaire :414.89PF-431396
CAS :<p>PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).</p>Formule :C22H21F3N6O3SDegré de pureté :98.83% - 99.82%Couleur et forme :SolidMasse moléculaire :506.5Fangchinoline
CAS :<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Formule :C37H40N2O6Degré de pureté :99.86% - >99.99%Couleur et forme :SolidMasse moléculaire :608.72AMP-945
CAS :<p>AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.</p>Formule :C28H32F3N5O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :527.58PF-562271 hydrochloride
CAS :<p>PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.</p>Formule :C21H20F3N7O3SHClDegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :543.95PF-573228
CAS :<p>PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.</p>Formule :C22H20F3N5O3SDegré de pureté :96.58% - 99.51%Couleur et forme :SolidMasse moléculaire :491.49Nitidine chloride
CAS :<p>1.</p>Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82BI-4464
CAS :<p>BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC</p>Formule :C28H28F3N5O4Degré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :555.55Batatasin III
CAS :<p>Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer</p>Formule :C15H16O3Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :244.29Defactinib
CAS :<p>Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.</p>Formule :C20H21F3N8O3SDegré de pureté :98% - 99.71%Couleur et forme :SolidMasse moléculaire :510.49NVP-TAE 226
CAS :<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Formule :C23H25ClN6O3Degré de pureté :98.07% - 98.78%Couleur et forme :SolidMasse moléculaire :468.94PF-562271 besylate
CAS :<p>PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.</p>Formule :C21H20F3N7O3S·C6H6O3SDegré de pureté :97.65% - 99.01%Couleur et forme :SolidMasse moléculaire :665.66PND-1186
CAS :<p>PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).</p>Formule :C25H26F3N5O3Degré de pureté :99.14% - 99.75%Couleur et forme :SolidMasse moléculaire :501.5CEP-37440
CAS :<p>CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).</p>Formule :C30H38ClN7O3Degré de pureté :98.86% - 99.98%Couleur et forme :SolidMasse moléculaire :580.12PF-562271
CAS :<p>PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).</p>Formule :C21H20F3N7O3SDegré de pureté :97.17% - >99.99%Couleur et forme :SolidMasse moléculaire :507.49FAK activator 1
CAS :<p>ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.</p>Formule :C23H26F3N3O3Degré de pureté :99.19%Couleur et forme :SoildMasse moléculaire :449.47Y 11
CAS :<p>focal adhesion kinase (FAK) inhibitor</p>Formule :C8H17BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.15FAK-IN-8
CAS :<p>FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].</p>Formule :C15H9Cl2N3O2SCouleur et forme :SolidMasse moléculaire :366.22TG53
CAS :<p>TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.</p>Formule :C21H22ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.88FLT3-IN-17
CAS :<p>FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.</p>Formule :C23H24N6O2S2Couleur et forme :SolidMasse moléculaire :480.61ProMMP-9 inhibitor-3c
CAS :<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Formule :C18H20FN3O2SCouleur et forme :SolidMasse moléculaire :361.43FAK inhibitor 5
CAS :<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Formule :C20H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.46NAMI-A
CAS :<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Formule :C8H15Cl4N4ORuSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.18FAK inhibitor 2
CAS :<p>FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .</p>Formule :C29H33F3N8O2S2Couleur et forme :SolidMasse moléculaire :646.75Adhesamine
CAS :<p>Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.</p>Formule :C24H32Cl4N8O2S2Couleur et forme :SolidMasse moléculaire :670.51Defactinib hydrochloride
CAS :<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Formule :C20H22ClF3N8O3SDegré de pureté :98.06% - 98.78%Couleur et forme :SolidMasse moléculaire :546.95Conteltinib
CAS :<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Formule :C32H45N9O3SDegré de pureté :98.12% - 99.54%Couleur et forme :SolidMasse moléculaire :635.82Roslin 2 bromide
CAS :<p>Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.</p>Formule :C13H19BrN4Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :311.22FC 11
CAS :<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Formule :C41H42F3N13O9SCouleur et forme :SolidMasse moléculaire :949.91Ifebemtinib
CAS :<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Formule :C28H28F4N6O4Degré de pureté :98.84% - 99.85%Couleur et forme :SolidMasse moléculaire :588.55FAK-IN-21
CAS :<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52OXA-11
CAS :<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Formule :C37H49F3N7O5PDegré de pureté :98.70% - 99.20%Couleur et forme :SolidMasse moléculaire :759.8FAK-IN-6
<p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>Formule :C25H31ClN5O6PSCouleur et forme :SolidMasse moléculaire :596.04FAK-IN-23
CAS :<p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>Formule :C32H38F3N5O8Couleur et forme :SolidMasse moléculaire :677.668FAK inhibitor 6
CAS :<p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>Formule :C25H24FN5O2SCouleur et forme :SolidMasse moléculaire :477.55Pyk2-IN-2
CAS :<p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>Formule :C27H27N7OCouleur et forme :SolidMasse moléculaire :465.55FAK-IN-3
<p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>Formule :C28H28N6O4Couleur et forme :SolidMasse moléculaire :512.56FAK-IN-26
CAS :<p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>Formule :C20H19BrFN5O2Couleur et forme :SolidMasse moléculaire :460.30FAK inhibitor 7
CAS :<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Formule :C32H37N7O3Couleur et forme :SolidMasse moléculaire :567.68JP-153
CAS :<p>JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.</p>Formule :C21H19NO5Couleur et forme :SolidMasse moléculaire :365.379Si306
CAS :<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94PF-03814735
CAS :<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48
