FAK
Les inhibiteurs de la kinase d'adhésion focale (FAK) ciblent la FAK, une kinase impliquée dans l'adhésion cellulaire, la migration et l'angiogenèse. La FAK est fréquemment surexprimée dans les tumeurs et contribue à la formation de nouveaux vaisseaux sanguins qui alimentent la tumeur en nutriments. L'inhibition de la FAK peut perturber ces processus, faisant des inhibiteurs de la FAK des outils précieux en thérapie anticancéreuse et en recherche sur l'angiogenèse. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la FAK de haute qualité pour soutenir vos recherches en biologie cellulaire, cancer et angiogenèse.
72 produits trouvés pour "FAK"
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ProMMP-9 inhibitor-3c
CAS :<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Formule :C18H20FN3O2SCouleur et forme :SolidMasse moléculaire :361.43FAK inhibitor 5
CAS :<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Formule :C20H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.46NAMI-A
CAS :<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Formule :C8H15Cl4N4ORuSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.18FAK inhibitor 2
CAS :<p>FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .</p>Formule :C29H33F3N8O2S2Couleur et forme :SolidMasse moléculaire :646.75Adhesamine
CAS :<p>Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.</p>Formule :C24H32Cl4N8O2S2Couleur et forme :SolidMasse moléculaire :670.51Defactinib hydrochloride
CAS :<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Formule :C20H22ClF3N8O3SDegré de pureté :98.06% - 98.78%Couleur et forme :SolidMasse moléculaire :546.95Conteltinib
CAS :<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Formule :C32H45N9O3SDegré de pureté :98.12% - 99.54%Couleur et forme :SolidMasse moléculaire :635.82Roslin 2 bromide
CAS :<p>Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.</p>Formule :C13H19BrN4Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :311.22FC 11
CAS :<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Formule :C41H42F3N13O9SCouleur et forme :SolidMasse moléculaire :949.91Ifebemtinib
CAS :<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Formule :C28H28F4N6O4Degré de pureté :98.84% - 99.85%Couleur et forme :SolidMasse moléculaire :588.55FAK-IN-21
CAS :<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52OXA-11
CAS :<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Formule :C37H49F3N7O5PDegré de pureté :98.70% - 99.20%Couleur et forme :SolidMasse moléculaire :759.8FAK-IN-6
<p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>Formule :C25H31ClN5O6PSCouleur et forme :SolidMasse moléculaire :596.04FAK-IN-23
CAS :<p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>Formule :C32H38F3N5O8Couleur et forme :SolidMasse moléculaire :677.668FAK inhibitor 6
CAS :<p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>Formule :C25H24FN5O2SCouleur et forme :SolidMasse moléculaire :477.55Pyk2-IN-2
CAS :<p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>Formule :C27H27N7OCouleur et forme :SolidMasse moléculaire :465.55FAK-IN-3
<p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>Formule :C28H28N6O4Couleur et forme :SolidMasse moléculaire :512.56FAK-IN-26
CAS :<p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>Formule :C20H19BrFN5O2Couleur et forme :SolidMasse moléculaire :460.30FAK inhibitor 7
CAS :<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Formule :C32H37N7O3Couleur et forme :SolidMasse moléculaire :567.68JP-153
CAS :<p>JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.</p>Formule :C21H19NO5Couleur et forme :SolidMasse moléculaire :365.379Si306
CAS :<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94PF-03814735
CAS :<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48
