Thrombine
Les inhibiteurs de la thrombine sont des composés qui bloquent la thrombine, une enzyme impliquée dans le processus de coagulation sanguine, qui joue également un rôle dans la promotion de l'angiogenèse. La thrombine peut stimuler la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant ainsi leur croissance et leurs métastases. En inhibant la thrombine, ces composés peuvent réduire l'angiogenèse et la progression tumorale. Les inhibiteurs de la thrombine sont importants à la fois dans la recherche sur le cancer et dans l'étude des maladies vasculaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de la thrombine de haute qualité pour soutenir vos recherches en hémostase, oncologie et angiogenèse.
47 produits trouvés pour "Thrombine"
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Dabigatran ethyl ester hydrochloride
CAS :<p>Dabigatran prevents blood clots, inhibiting NQO2 and thrombin with IC50 0.8 μM.</p>Formule :C27H30ClN7O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :536.03Dabigatran etexilate
CAS :<p>Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.</p>Formule :C34H41N7O5Degré de pureté :98.19% - 99.98%Couleur et forme :White PowderMasse moléculaire :627.73Ichorcumab
CAS :<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :LiquidThrombin inhibitor 13
<p>Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.</p>Formule :C16H17ClN6OSCouleur et forme :SolidMasse moléculaire :376.864Thrombin (MW 37kDa)
CAS :<p>Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.</p>Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :37kDaH-Gly-Arg-pNA dihydrochloride
CAS :<p>H-Gly-Arg-pNA 2HCl, a peptide, binds 1,2 thrombin; colorimetric quantification at 405 nm indicates thrombin activity.</p>Formule :C14H23Cl2N7O4Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :424.28Fibrinopeptide B, human
CAS :<p>Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.</p>Formule :C66H93N19O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1552.56Platelet aggregation-IN-1
<p>Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.</p>Formule :C18H13N3O4Masse moléculaire :335.09061Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidSulodexide
CAS :<p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>Couleur et forme :SolidBefovacimab
CAS :<p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>Couleur et forme :LiquidPM 102
CAS :<p>Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).</p>Formule :C235H425N111O64Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5830Metolazone
CAS :<p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>Formule :C16H16ClN3O3SDegré de pureté :98.14% - 98.5%Couleur et forme :Crystals From Ethanol SolidMasse moléculaire :365.83Coagulation Factor II Protein, Rat, Recombinant (His)
<p>Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :69.5 kDa (predicted)Anti-Coagulation Factor II Antibody (2P591)
<p>Anti-Coagulation Factor II Antibody (2P591) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (2P591) can be used in WB.</p>Couleur et forme :Odour LiquidAnti-Coagulation Factor II Antibody (8M286)
<p>Anti-Coagulation Factor II Antibody (8M286) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (8M286) can be used in ELISA.</p>Couleur et forme :Odour LiquidDabigatran ethyl ester
CAS :<p>Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.</p>Formule :C27H29N7O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :499.56Coagulation Factor II Protein, Mouse, Recombinant (His)
<p>Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :69.3 kDa (predicted); 85 kDa (reducing conditions)TRAP-6
CAS :<p>TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).</p>Formule :C34H56N10O9Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :748.87Lusutrombopag
CAS :<p>Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with</p>Formule :C29H32Cl2N2O5SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :591.55Avatrombopag
CAS :<p>Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation</p>Formule :C29H34Cl2N6O3S2Degré de pureté :99.01% - 99.63%Couleur et forme :SolidMasse moléculaire :649.65Dabigatran
CAS :<p>Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.</p>Formule :C25H25N7O3Degré de pureté :97.44% - 98.7%Couleur et forme :Tan SolidMasse moléculaire :471.51Enoxaparin sodium
CAS :<p>Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.</p>Formule :C42H59N3Na4O35S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1322AEBSF hydrochloride
CAS :<p>AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.</p>Formule :C8H11ClFNO2SDegré de pureté :98% - 99.81%Couleur et forme :White PowderMasse moléculaire :239.69H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS :<p>H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).</p>Formule :C27H38Cl2N8O5Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :625.55Bivalirudin
CAS :<p>Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting</p>Formule :C98H138N24O33Degré de pureté :98.8% - >99.99%Couleur et forme :White To Off-White PowderMasse moléculaire :2180.29Dabigatran Etexilate Mesylate
CAS :<p>Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.</p>Formule :C34H41N7O5·CH4O3SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :723.84Argatroban Monohydrate
CAS :<p>Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formule :C23H38N6O6SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :526.65Edoxaban Tosylate Monohydrate
CAS :<p>Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.</p>Formule :C31H40ClN7O8S2Degré de pureté :99.86% - 99.91%Couleur et forme :SolidMasse moléculaire :738.27Cycloolivil
CAS :<p>Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees.</p>Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4NQ301
CAS :<p>NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).</p>Formule :C18H12ClNO3Degré de pureté :99.74% - 99.76%Couleur et forme :SolidMasse moléculaire :325.75Ximelagatran
CAS :<p>Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.</p>Formule :C24H35N5O5Degré de pureté :95.48% - 99.60%Couleur et forme :SolidMasse moléculaire :473.57MNS
CAS :<p>MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.</p>Formule :C9H7NO4Degré de pureté :98.53%Couleur et forme :Yellow PowderMasse moléculaire :193.16Argatroban
CAS :<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formule :C23H36N6O5SDegré de pureté :99.77% - >99.99%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :508.63Efegatran sulfate
CAS :<p>Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.</p>Formule :C21H34N6O7SDegré de pureté :≥98% - ≥98%Couleur et forme :SolidMasse moléculaire :514.6OM-189
CAS :<p>OM-189 is a selective inhibitor of synthetic thrombin.</p>Formule :C24H36N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.65Atopaxar Hydrobromide
CAS :<p>Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Formule :C29H39BrFN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.54Flovagatran
CAS :<p>Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.</p>Formule :C27H36BN3O7Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :525.4Atopaxar
CAS :<p>Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Formule :C29H38FN3O5Degré de pureté :97.07% - 98.07%Couleur et forme :SolidMasse moléculaire :527.63Melagatran
CAS :<p>Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.</p>Formule :C22H31N5O4Degré de pureté :98.29% - >99.99%Couleur et forme :SolidMasse moléculaire :429.51NP-313
CAS :<p>NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.</p>Formule :C12H8ClNO3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :249.65SCH79797 dihydrochloride
CAS :<p>SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.</p>Formule :C23H27Cl2N5Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :444.4Thrombin inhibitor 1
CAS :<p>Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).</p>Formule :C22H20Cl2F2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.32Odiparcil
CAS :<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Formule :C15H16O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.35LK-732
CAS :<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59SAR107375
CAS :<p>SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].</p>Formule :C24H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :568.11Antiplatelet agent 3
CAS :<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671
