Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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TOPOI/PARP-1-IN-2
<p>TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.</p>Formule :C16H11ClN4O2SCouleur et forme :SolidMasse moléculaire :358.80MDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Formule :C25H24Cl2FN3O3Couleur et forme :SolidMasse moléculaire :504.38β-Glucuronide-dPBD-PEG5-NH2
CAS :<p>β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate</p>Formule :C78H101N7O35Couleur et forme :SolidMasse moléculaire :1696.66Apoptolidin
CAS :<p>Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.</p>Formule :C58H96O21Couleur et forme :SolidMasse moléculaire :1129.385RMC-9805
CAS :<p>RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.</p>Formule :C63H88F3N11O7Degré de pureté :98.10% - 99.51%Couleur et forme :SolidMasse moléculaire :1168.444-Nitrothalidomide
CAS :<p>4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.</p>Formule :C13H9N3O6Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :303.23c-Met/HDAC-IN-4
<p>c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.</p>Formule :C37H36N8OCouleur et forme :SolidMasse moléculaire :608.73Z-Ala-Ala-Asp-CMK
CAS :<p>Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.</p>Formule :C19H24ClN3O7Degré de pureté :99.967%Couleur et forme :SolidMasse moléculaire :441.86Solasodine hydrochloride
CAS :<p>Solasodine hydrochloride (90 μM; 2 days) treatment induced significant budding in P19 cells. This compound strongly stimulated the expression of various neuronal markers, including βIII-tubulin, synaptophysin, MAP2, ChAT, and the neural progenitor marker doublecortin. Predominantly, Solasodine hydrochloride directed the differentiation of P19 cells towards neuronal pathways.</p>Formule :C27H44ClNO2Couleur et forme :SolidMasse moléculaire :450.1AZD5582 dihydrochloride
CAS :<p>Dimeric Smac mimetic inhibits XIAP, cIAP1/2 (IC50: 15/15/21 nM); binds BIR3 domain; degrades cIAPs; induces apoptosis in cancer cells; shrinks tumors in mice.</p>Formule :C58H80Cl2N8O8Couleur et forme :SolidMasse moléculaire :1088.23CNDAC hydrochloride
CAS :<p>CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.</p>Formule :C10H13ClN4O4Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :288.69PPIA-IN-1
<p>PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 μM. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 μM in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.</p>Formule :C23H21Cl2FN4O7Couleur et forme :SolidMasse moléculaire :555.34S-Adenosyl-L-methionine iodide
CAS :<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Formule :C15H23IN6O5SCouleur et forme :SolidMasse moléculaire :526.35VEGFR-2-IN-68
<p>VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.</p>Formule :C27H25N5O2SCouleur et forme :SolidMasse moléculaire :483.1729Targaprimir-96
CAS :<p>Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.</p>Formule :C77H102N18O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1391.75Ianalumab
CAS :<p>Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.44 kDaTaltirelin acetate
CAS :<p>Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an</p>Formule :C19H27N7O7Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :465.46SC-2001
CAS :<p>SC-2001 inhibits MCL-1 and STAT3, enhances SHP-1, induces apoptosis in breast cancer, and counters STAT3-driven sorafenib resistance in liver cancer.</p>Formule :C18H14BrN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.23Apoptosis inducer 29
<p>Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.</p>Formule :C33H46ClN3O3Couleur et forme :SolidMasse moléculaire :568.19Pomstafib-2
CAS :<p>Pomstafib-2, a potent and selective inhibitor of STAT5b, reduces pSTAT5b expression and effectively induces apoptosis [1] [2].</p>Formule :C52H66N2O20P2Couleur et forme :SolidMasse moléculaire :1101.03
