Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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UBX1325
CAS :<p>UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.</p>Formule :C53H59ClF3N6O10PS3Couleur et forme :SolidMasse moléculaire :1159.69XM-U-14
<p>XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.</p>Couleur et forme :Odour SolidThalidomide-NH-C4-NH2 TFA
CAS :<p>Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.</p>Formule :C19H21F3N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.39Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Degré de pureté :98%Couleur et forme :Odour SolidD-CopA3
CAS :<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.81HEMTAC CDK4/6 degrader 1
CAS :<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.498-Aminoadenosine
CAS :<p>8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.</p>Formule :C10H14N6O4Couleur et forme :SolidMasse moléculaire :282.26Linsidomine
CAS :<p>Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.</p>Formule :C6H10N4O2Couleur et forme :Solid Off-WhiteMasse moléculaire :170.17Delmitide
CAS :<p>Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.</p>Formule :C59H105N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1228.57Antiproliferative agent-25
<p>Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.</p>Formule :C20H21BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.3Azurin p28 peptide
CAS :<p>Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.</p>Formule :C122H197N31O47S2Couleur et forme :SolidMasse moléculaire :2914.18Prodigiosin hydrochloride
CAS :<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>Formule :C20H26ClN3OCouleur et forme :SolidMasse moléculaire :359.9JC2-11
CAS :<p>JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.</p>Formule :C17H15FO4Degré de pureté :98.6%Couleur et forme :SoildMasse moléculaire :302.3CYP51/PD-L1-IN-3
<p>CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM</p>Formule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55S-Adenosyl-L-methionine
CAS :<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Pipermethystine
<p>Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.</p>Formule :C16H17NO4Couleur et forme :SolidMasse moléculaire :287.315Vonlerizumab
<p>Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.5 kDaALK/ROS1 inhibitor 2e HCL
<p>(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.</p>Formule :C30H36ClF3N6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :621.09ZMF-24
<p>ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent that exhibits IC50 values of 0.22 μM and 0.44 μM against BT-549 and MDA-MB-231 TNBC cell proliferation, respectively. It targets the eukaryotic translation initiation factor 3 subunit D (EIF3D), disrupting TNBC's energy supply by inhibiting glycolysis. Additionally, ZMF-24 induces TNBC cell apoptosis (apoptosis) by stimulating sustained endoplasmic reticulum stress.</p>Couleur et forme :Odour SolidNemorosone
CAS :<p>Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.</p>Formule :C33H42O4Couleur et forme :SolidMasse moléculaire :502.695Anti-inflammatory agent 42
CAS :<p>Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.</p>Formule :C20H12N2OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :328.39Apoptosis inducer 26
<p>Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.</p>Formule :C40H36AgClN4P2SCouleur et forme :SolidMasse moléculaire :810.07TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47Tebentafusp
CAS :<p>Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.</p>Degré de pureté :97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Couleur et forme :LiquidEGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Degré de pureté :98%Couleur et forme :Odour SolidPetromurin C
CAS :<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Formule :C26H24N2O5Couleur et forme :SolidMasse moléculaire :444.487Necroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Couleur et forme :Odour SolidEGFR T790M/L858R-IN-2
<p>EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.</p>Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57TD52 dihydrochloride
<p>TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.</p>Formule :C24H18Cl2N4Degré de pureté :97.23%Couleur et forme :SoildMasse moléculaire :433.33Thalidomide-NH-C8-NH2
CAS :<p>Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.</p>Formule :C21H28N4O4Couleur et forme :SolidMasse moléculaire :400.479Nrf2 activator 19
<p>Nrf2 activator 19 is a compound capable of crossing the blood-brain barrier and acts as an NRF2/HO-1 activator, offering potent antioxidant and neuroprotective effects. It effectively reduces brain damage and minimizes the accumulation of Reactive Oxygen Species (ROS). Additionally, Nrf2 activator 19 inhibits neuronal apoptosis, aiding in the recovery of neural function and motor skills. It has demonstrated significant potential in ischemic stroke research.</p>Couleur et forme :Odour SolidPARP1-IN-17
<p>PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.</p>Degré de pureté :98%Couleur et forme :Odour SolidThymidine 3',5'-disphosphate
CAS :<p>pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.</p>Formule :C10H16N2O11P2Couleur et forme :SolidMasse moléculaire :402.19Enniatin A1
CAS :<p>Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).</p>Formule :C35H61N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.885TNF/IFNγ-IN-1
CAS :<p>TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.</p>Formule :C20H23N3O6Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :401.41Bcl-2-IN-22
<p>Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.</p>Couleur et forme :Odour SolidPolyphyllin G
CAS :<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.21LS-106
<p>LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.</p>Formule :C24H28BrClN5OPCouleur et forme :SolidMasse moléculaire :548.84Bim BH3, Peptide IV
CAS :<p>This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.</p>Formule :C145H222N44O41SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3269.65DB818 dihydrochloride
<p>DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).</p>Couleur et forme :Odour SolidFW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Formule :C24H27N7OCouleur et forme :SolidMasse moléculaire :429.517AP1867-2-(carboxymethoxy)
CAS :<p>AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG</p>Formule :C38H47NO11Couleur et forme :SolidMasse moléculaire :693.78Maceneolignan A
CAS :<p>Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibiting</p>Formule :C21H24O5Couleur et forme :SolidMasse moléculaire :356.41Tubulin/HDAC-IN-2
<p>Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM</p>Formule :C21H19FN2O4Couleur et forme :SolidMasse moléculaire :382.38Onfekafusp alfa
CAS :<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Couleur et forme :Liquidc-Met/HDAC-IN-4
<p>c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.</p>Formule :C37H36N8OCouleur et forme :SolidMasse moléculaire :608.73Antiproliferative agent-59
<p>Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.</p>Formule :C26H22N2O3Couleur et forme :SolidMasse moléculaire :410.46HDAC6-IN-16
<p>HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony</p>Formule :C23H19N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.48Episilvestrol
CAS :<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Formule :C34H38O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.66FF2039
<p>FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.</p>Formule :C43H56Cl3N5O6Couleur et forme :SolidMasse moléculaire :845.29Thalidomide-NH-PEG7
<p>Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.</p>Formule :C27H39N3O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.61CRM1-IN-2
<p>CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibiting</p>Formule :C29H48N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.7ZX782
<p>ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.</p>Formule :C39H48ClN5O8Couleur et forme :SolidMasse moléculaire :750.28Bfl-1-IN-6
<p>Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.</p>Formule :C22H24ClFN2O2Couleur et forme :SolidMasse moléculaire :402.89Thalidomide-O-amido-PEG4-azide
CAS :<p>Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].</p>Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56Schisandronic acid
CAS :<p>Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.</p>Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.68UZH1a
CAS :<p>UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.</p>Formule :C32H42N6O3Couleur et forme :SoildMasse moléculaire :558.71iNOs-IN-5
<p>iNOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056). It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.</p>Couleur et forme :Odour SolidCQ-ER
<p>CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).</p>Formule :C33H33N7O6SCouleur et forme :SolidMasse moléculaire :655.72Lisaftoclax
CAS :<p>Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.</p>Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.42Ferumoxytol
CAS :<p>Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.</p>Couleur et forme :SolidTengonermin
CAS :<p>Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.</p>Couleur et forme :LiquidChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21Ac-Pro-Gly-Pro-OH
CAS :<p>Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.</p>Formule :C14H21N3O5Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :311.33LSD1-IN-36
<p>LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.</p>Formule :C22H25N3O6SCouleur et forme :SolidMasse moléculaire :459.52Thalidomide-O-PEG4-azide
CAS :<p>Thalidomide-O-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formule :C23H29N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.5Thiocolchicine
CAS :<p>Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.</p>Formule :C22H25NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :415.5MS78
<p>MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.</p>Formule :C57H66FN9O6SCouleur et forme :SolidMasse moléculaire :1024.25MS1943
CAS :<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93Bornyl acetate
CAS :<p>Bornyl acetate (Isobornyl acetate) has an anti-inflammatory effect. It is the volatile ingredient in some Chinese traditional herbs and numerous conifer oils.</p>Formule :C12H20O2Degré de pureté :99.19%Couleur et forme :LiquidMasse moléculaire :196.29Mitochondria modulator-2
<p>Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.</p>Formule :C63H50F12IrN6OP3Couleur et forme :SolidMasse moléculaire :1420.23CDK-IN-14
<p>CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.</p>Couleur et forme :Odour SolidTS-24
CAS :<p>TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.</p>Formule :C20H15NO2Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :301.34CV-4-26
<p>CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).</p>Couleur et forme :Odour SolidFludarabine triphosphate
CAS :<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Formule :C10H15FN5O13P3Couleur et forme :SolidMasse moléculaire :525.17Destruxin B
CAS :<p>Destruxin B: cyclic peptide from Metarhizium fungus, induces apoptosis in lung cancer via mitochondrial pathway.</p>Formule :C30H51N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.766Pomalidomide-C5-Dovitinib
CAS :<p>Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in</p>Formule :C39H38FN9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :747.77MDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Formule :C25H24Cl2FN3O3Couleur et forme :SolidMasse moléculaire :504.38ABBV-167
CAS :<p>ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.</p>Formule :C46H53ClN7O11PSCouleur et forme :SolidMasse moléculaire :978.45KRAS inhibitor-40
CAS :<p>KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.</p>Formule :C53H66ClF4N9O8SCouleur et forme :SolidMasse moléculaire :1100.66JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Formule :C26H32N8O3SCouleur et forme :SolidMasse moléculaire :536.655-Fluorouracil-13C,15N2
CAS :<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Formule :C4H3FN2O2Couleur et forme :SolidMasse moléculaire :133.057Thalidomide-5-propoxyethanamine
CAS :<p>Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.</p>Formule :C18H21N3O5Couleur et forme :SolidMasse moléculaire :359.38Iparomlimab
CAS :<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Couleur et forme :LiquidSTAT3-D11-PROTAC-VHL
<p>STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.</p>Couleur et forme :Odour SolidRIPK1-IN-17
CAS :<p>RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.</p>Formule :C26H19F4N3O3SDegré de pureté :95.22%Couleur et forme :SolidMasse moléculaire :529.51GSK-3β inhibitor 15
<p>GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-</p>Formule :C17H16N6OSCouleur et forme :SolidMasse moléculaire :352.41Ferroptosis-IN-12
<p>Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.</p>Couleur et forme :Odour SolidERK1/2 inhibitor 13
<p>ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.</p>Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62Anticancer agent 39
CAS :<p>Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.</p>Formule :C50H65N5O10Couleur et forme :SolidMasse moléculaire :896.08HDAC-IN-79
<p>HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM). Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.</p>Couleur et forme :Odour SolidH-20
CAS :<p>H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.</p>Formule :C44H64N10O15Couleur et forme :SolidMasse moléculaire :973.037MS41
CAS :<p>MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.</p>Formule :C56H70N8O9SCouleur et forme :SolidMasse moléculaire :1031.27Terrein
CAS :<p>Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.</p>Formule :C8H10O3Couleur et forme :SolidMasse moléculaire :154.16RSM3 TFA
<p>RSM3 TFA is a stapled peptide and an inhibitor of METTL3-METTL14, exhibiting a dissociation constant (Kd) of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA is utilized in cancer research.</p>Couleur et forme :Odour SolidOxybenzone-d3
<p>Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.</p>Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26Holothurin A
CAS :<p>Holothurin A is a triterpene glycoside.</p>Formule :C54H86NaO27SCouleur et forme :SolidMasse moléculaire :1222.3KSRP-IN-1
<p>KSRP-IN-1 (compound 8) acts as an inhibitor of KSRP, inducing cell cycle arrest and apoptosis (Apoptosis). This compound demonstrates antitumor activity.</p>Couleur et forme :Odour SolidCDK9-IN-24
<p>CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.</p>Formule :C27H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.55Anticancer agent 272
<p>Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.</p>Formule :C26H34Br2Cl4Cu2N8Couleur et forme :SolidMasse moléculaire :881.86192HSP90-IN-18
<p>HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.</p>Formule :C25H33FO3Couleur et forme :SolidMasse moléculaire :400.53YL5084
CAS :<p>YL5084 is a selective JNK2/3 inhibitor with IC50s: JNK2 (70 nM), JNK3 (84 nM), and antiproliferative, apoptosis-inducing effects.</p>Formule :C35H36N8O2Couleur et forme :SolidMasse moléculaire :600.71Apoptosis inducer 28
<p>Apoptosisinducer 28 (Compound X1) is an apoptosis inducer with demonstrated in vitro anticancer activity. It arrests the cell cycle at the G1 phase, promoting cell death and inducing apoptosis by disrupting the mitochondrial membrane potential.</p>Couleur et forme :Odour SolidMDMX/MDM2-IN-2
<p>MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.</p>Formule :C28H25Cl3FN3O3Couleur et forme :SolidMasse moléculaire :576.87MRIA9
CAS :<p>MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.</p>Formule :C24H22ClFN6O3Couleur et forme :SolidMasse moléculaire :496.92XIAP BIR2/BIR2-3 inhibitor-1
CAS :<p>XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].</p>Formule :C72H96N16O14Couleur et forme :SolidMasse moléculaire :1409.63Chaetoglobosin A
CAS :<p>Chaetoglobosin A, the active compound extracted of Penicillium aquamarinium, is a member of the cytochalasan family. It preferentially induces apoptosis.</p>Formule :C32H36N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.649Bak BH3
<p>Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.</p>Formule :C72H125N25O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1724.9Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS :<p>Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.</p>Formule :C25H35ClN4O9Couleur et forme :SolidMasse moléculaire :571.02PROTAC EGFR degrader 7
<p>Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.</p>Formule :C46H48N10O6Couleur et forme :SolidMasse moléculaire :836.94ATPase-IN-3
CAS :<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3Anticancer agent 273
<p>Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.</p>Couleur et forme :Odour SolidDidocosahexaenoin
CAS :<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Formule :C25H40O5Couleur et forme :SolidMasse moléculaire :420.58Pipernonaline
CAS :<p>Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.</p>Formule :C21H27NO3Couleur et forme :SolidMasse moléculaire :341.451BRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Couleur et forme :Odour SolidViolacein
CAS :<p>Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.</p>Formule :C20H13N3O3Couleur et forme :SolidMasse moléculaire :343.34BRD-810
CAS :<p>BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.</p>Formule :C39H44ClFN4O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :703.24AZT triphosphate TEA
<p>AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.</p>Couleur et forme :SolidPhotosensitizer-3
CAS :<p>Photosensitizer-3, generates single-linear oxygen upon near-infrared light excitation in combination with FAP,potent and selective killing cancer cells.</p>Formule :C29H33ClI2N2O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :746.85Curcumin 5-8
CAS :<p>CUR5-8: potent, oral CUR analog, reduces lipid droplets, boosts autophagy, hinders apoptosis, enhances insulin sensitivity.</p>Formule :C20H21NO4Couleur et forme :SolidMasse moléculaire :339.39Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Formule :C26H23N5OCouleur et forme :SolidMasse moléculaire :421.49Aphidicolin
CAS :<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Formule :C20H34O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :338.48PROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Formule :C32H29IN4O4S2Couleur et forme :SolidMasse moléculaire :724.63FLT3-IN-21
<p>FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.</p>Formule :C20H22FN5O2Couleur et forme :SolidMasse moléculaire :383.42MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.78Amino-PEG6-Thalidomide
<p>Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>Formule :C27H39N3O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.619,11-Dehydroergosterol peroxide
CAS :<p>9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.</p>Formule :C28H42O3Couleur et forme :SolidMasse moléculaire :426.641UCM-1336
CAS :<p>UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in</p>Formule :C26H37N3O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :423.59VEGFR-2-IN-53
<p>VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.</p>Couleur et forme :Odour SolidRO7567132
<p>RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.</p>Couleur et forme :Odour LiquidPhotosensitizer-5
<p>Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.</p>Formule :C35H26BF2IN4O2Couleur et forme :SolidMasse moléculaire :710.32Antitumor agent-145
CAS :<p>Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].</p>Formule :C44H34IrN5OSCouleur et forme :SolidMasse moléculaire :873.06Apoptosis inducer 27
<p>Apoptosisinducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer cells, demonstrating an IC50 of 12.8 μM and inducing early apoptosis in these cells. Additionally, it can bind to DNA molecules as well as Bax and Bcl-2 proteins, thereby inducing DNA damage.</p>Formule :C29H37BrN2Couleur et forme :SolidMasse moléculaire :493.52PROTAC CDK4/6 degrader 1
CAS :<p>PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis).</p>Formule :C41H47N11O6Couleur et forme :SolidMasse moléculaire :789.88VEGFR-2-IN-64
<p>VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.</p>Formule :C72H123N9O6Couleur et forme :SolidMasse moléculaire :1210.8NTR 368
CAS :<p>cytoplasmic peptide of the neurotrophin receptor p75NTR</p>Formule :C69H124N22O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1565.86HDAC6 degrader-5
<p>HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.</p>Formule :C21H22N4O3Couleur et forme :SolidMasse moléculaire :378.424PROTAC EGFR degrader 5
CAS :<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Formule :C57H72FN13O5SCouleur et forme :SolidMasse moléculaire :1070.33Ferroptosis inducer-4
<p>Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.</p>Formule :C33H64NO7PCouleur et forme :SolidMasse moléculaire :617.84PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52RAR/RXR agonist-1
<p>Compound 7, also known as RAR/RXR agonist-1, is a chlorinated isomer of retinoic acid and acts as a selective RARα agonist and a partial RXRα agonist. It is capable of activating RXRα, thereby inducing G2/M arrest and apoptosis in cancer cells.</p>Formule :C25H27ClO3Couleur et forme :SolidMasse moléculaire :410.93Placulumab
CAS :<p>Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.</p>Couleur et forme :LiquidFludarabine triphosphate trisodium
<p>Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.</p>Formule :C10H12FN5Na3O13P3Couleur et forme :SolidMasse moléculaire :591.12BK50164
CAS :<p>BK50164: CD73 inhibitor, IC50=13.089µM; binds CD99, KD=1.5µM; anticancer, induces apoptosis, arrests sub-G1.</p>Formule :C13H13ClFN5O7Couleur et forme :SolidMasse moléculaire :405.72Ac-LEHD-AMC
CAS :<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formule :C33H41N7O11Couleur et forme :SolidMasse moléculaire :711.729VEGFR-2-IN-36
<p>VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated</p>Formule :C24H23N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.48ZZM-1220
<p>ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.</p>Formule :C25H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.53PUMA BH3
<p>PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.</p>Formule :C128H202N42O43SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3049.3TQB-2858
<p>TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).</p>Couleur et forme :Odour LiquidApoptolidin
CAS :<p>Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.</p>Formule :C58H96O21Couleur et forme :SolidMasse moléculaire :1129.385hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Couleur et forme :Odour SolidAEG 3482
CAS :<p>AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.</p>Formule :C10H8N4O2S2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :280.33NL13
<p>NL13, a Polo-like kinase 4 (PLK4) inhibitor, exhibits an IC 50 value of 2.32 μM. It demonstrates the ability to suppress the viability of PC3 and DU145 prostate cancer cells with respective IC 50 values of 3.51 μM and 2.53 μM. NL13 also inhibits tumor growth in prostate cancer mice. Additionally, it deactivates the AKT signaling pathway by reducing CCNB1/CDK1 levels, leading to G2/M cell cycle arrest and initiating apoptosis through caspase-9/caspase-3 cleavage.</p>Formule :C22H19Cl2NO2Couleur et forme :SolidMasse moléculaire :400.3Kurzipene D
CAS :<p>Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.</p>Formule :C26H36O8Couleur et forme :SolidMasse moléculaire :476.56EGCG-4″-sulfate
CAS :<p>EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly against</p>Formule :C22H18O14SCouleur et forme :SolidMasse moléculaire :538.43Nrf2 activator-11
<p>Nrf2 activator-11 (compound M11) is a Nrf2 activator that possesses blood-brain barrier permeability and offers anti-oxidation, anti-inflammation, anti-ferroptosis, and anti-apoptosis properties. It is applicable for use in studying cerebral ischemia-reperfusion (CI/R) injury models.</p>Formule :C20H23N3O2Couleur et forme :SolidMasse moléculaire :337.42DAPK-IN-2
CAS :<p>DAPK-IN-2: DAPK inhibitor with anticancer potential. Used in cerebral infarction and ischemia research.</p>Formule :C17H14N2O4Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :310.3FMP
<p>FMP is a platinum (IV) complex. It significantly upregulates the expression of γ-H2AX and p53, enhances ROS production, and markedly increases the expression of apoptosis (Apoptosis) related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP exhibits antiproliferative activity against breast cancer.</p>Formule :C18H18Cl2N2O7PtCouleur et forme :SolidMasse moléculaire :640.33Tubulin polymerization-IN-76
<p>Tubulin polymerization-IN-76 (compound 20b) is a potent and orally active inhibitor of tubulin polymerization. It acts at the colchicine binding site to inhibit tubulin polymerization with an IC50 value of 2.505 μM, effectively disrupting the intracellular microtubule network and interfering with mitosis. Tubulin polymerization-IN-76 shows significant inhibitory effects on MGC-803 and HGC-27 cells, with IC50 values of 1.61 and 1.82 nM, respectively. It effectively suppresses colony formation and cell migration activities in these cell lines, inducing G2/M phase cell cycle arrest and apoptosis (Apoptosis). Furthermore, Tubulin polymerization-IN-76 exhibits broad-spectrum antiproliferative activity.</p>Formule :C20H21N5SCouleur et forme :SolidMasse moléculaire :363.48β-Amyloid (1-40) (rat)
CAS :<p>Rat form of the beta-Amyloid (1-40) peptide</p>Formule :C190H291N51O57SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4233.76Methylene Violet 3RAX
CAS :<p>Methylene Violet 3RAX is a cationic dye that is a potential photosensitizer in photodynamic therapy and has antitumor activity.</p>Formule :C22H23ClN4Degré de pureté :97.03% - 97.17%Couleur et forme :SolidMasse moléculaire :378.9EGFR-IN-86
<p>EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell</p>Formule :C20H21N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.49PROTAC FGFR2 degrader 1
<p>PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.</p>Couleur et forme :Odour SolidFGFR1/VEGFR2-IN-2
<p>FGFR1/VEGFR2-IN-2 (compound 6) is a dual inhibitor targeting both VEGFR2 and FGFR1 with IC50 values of 0.025 µM and 0.026 µM, respectively. This compound also exhibits inhibitory effects on EGFR and PDGFR-β, with IC50 values of 0.106 µM and 0.077 µM, respectively. FGFR1/VEGFR2-IN-2 demonstrates significant anticancer activity in the NCI-60 cell lines, showing a growth inhibition (GI) of 60.38%. In T-47D cell lines, it achieves an IC50 of 8.51 µM, exhibits anti-migratory properties, induces cell cycle arrest in the G1 phase, and promotes both apoptosis and necrosis. Additionally, while it has an IC50 greater than 100 µM in MCF-7 cell lines, it does so with an IC50 of 69.17 µM in MDA-MB-231 cell lines and shows no toxicity to normal cells.</p>Formule :C21H15ClF3NO4SCouleur et forme :SolidMasse moléculaire :469.86PQ401
CAS :<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79KWCN-41
CAS :<p>KWCN-41, a RIPK1 inhibitor with 88 nM IC50, blocks necrosis, spares apoptosis, and is anti-inflammatory.</p>Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35GPLGIAGQ
CAS :<p>GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.</p>Formule :C31H53N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :711.81DB0614
CAS :<p>DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.</p>Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95ReACp53 acetate
<p>ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.</p>Formule :C110H210N52O26Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :2677.18icFSP1
CAS :<p>icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.</p>Formule :C26H25N3O5Degré de pureté :99.87% - 99.93%Couleur et forme :SoildMasse moléculaire :459.49Dapirolizumab
<p>Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.5 kDaPD0166285 dihydrochloride
CAS :<p>PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.</p>Formule :C26H29Cl4N5O2Couleur et forme :SolidMasse moléculaire :585.35Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formule :C59H54ClF6N8O4PRuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1220.6MC-25B
<p>MC-25B is a selective FKBP12 PROTAC degrader. It effectively degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a mechanism dependent on DCAF16.</p>Formule :C65H92ClN7O14Couleur et forme :SolidMasse moléculaire :1230.92Antitumor agent-61
CAS :<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Formule :C54H63FN5O10PCouleur et forme :SolidMasse moléculaire :992.08Nauclefine
CAS :<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Formule :C18H13N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :287.32Ganglioside GD3 disodium salt
CAS :<p>Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.</p>Formule :C70H123N3Na2O29Couleur et forme :SolidMasse moléculaire :1516.71PROTAC 20S proteasome subunit β5 degrader 1
<p>PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.</p>Couleur et forme :Odour SolidPRLX-93936 HCL
CAS :<p>PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.</p>Formule :C21H26Cl2N4O2Degré de pureté :98.4% - 99.94%Couleur et forme :SolidMasse moléculaire :437.37Ferroptosis-IN-13
<p>Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.</p>Formule :C32H30F2N4O3Couleur et forme :SolidMasse moléculaire :556.602Enniatin complex
CAS :<p>Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.</p>Degré de pureté :98%Couleur et forme :SolidCathepsin B
CAS :<p>Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.</p>Couleur et forme :SolidCDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Degré de pureté :98%Couleur et forme :Odour SolidCIGB-300 acetate
<p>CIGB-300 acetate (P15-Tat acetate) is a peptide that acts as an inhibitor of casein kinase 2 (CK2). It exhibits anticancer properties by disrupting the phosphorylation activity of CK2. CIGB-300 acetate induces apoptosis in various tumor cell lines and is applicable for cancer research.</p>Couleur et forme :Odour SolidJAK/HDAC-IN-2
<p>JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.</p>Formule :C28H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.7Anti-inflammatory agent 95
<p>Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.</p>Formule :C16H21NO4Couleur et forme :SolidMasse moléculaire :291.34CLEFMA
CAS :<p>CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.</p>Formule :C23H17Cl2NO4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :442.294-Epianhydrotetracycline hydrochloride
CAS :<p>EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.</p>Formule :C22H23ClN2O7Couleur et forme :SolidMasse moléculaire :462.88Thalidomide-O-PEG4-Boc
CAS :<p>Thalidomide-O-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formule :C28H38N2O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.61Anagrelide hydrochloride monohydrate
CAS :<p>Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.</p>Formule :C10H10Cl3N3O2Couleur et forme :SolidMasse moléculaire :310.56p38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892FPR1 antagonist 2
<p>Compound 25b, an FPR1 antagonist, exhibits potent inhibition of the formyl peptide receptor 1 with an IC50 of 70 nM.</p>Formule :C25H25F3O5Couleur et forme :SolidMasse moléculaire :462.46Waltonitone
CAS :<p>Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.</p>Formule :C30H48O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.7YB-0158 ammonium
<p>YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic with translation-enhancing potential and anticancer activity.</p>Formule :C32H40N9O7PDegré de pureté :99.14% - 99.18%Couleur et forme :SolidMasse moléculaire :693.69β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS :<p>β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-</p>Formule :C80H102F3N7O37Couleur et forme :SolidMasse moléculaire :1810.69Multi-kinase-IN-4
<p>Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.</p>Formule :C21H20ClFN2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.91AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Formule :C43H67Cl2NO12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.9Z-Asp-CH2-DCB
CAS :<p>Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.</p>Formule :C20H17Cl2NO7Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :454.26(E/Z)-Squalene
CAS :<p>(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.</p>Formule :C30H50Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :410.72
