Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5593 produits trouvés pour "Apoptose"
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AGN 192870
CAS :<p>AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.</p>Formule :C27H22O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :378.46Boserolimab
CAS :<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Couleur et forme :LiquidMcl-1 inhibitor 13
CAS :<p>Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].</p>Formule :C47H45ClFN7O6Couleur et forme :SolidMasse moléculaire :858.35Bcl-2-IN-13
CAS :<p>Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].</p>Formule :C42H44ClN7O6S3Couleur et forme :SolidMasse moléculaire :874.49HDAC1/CDK7-IN-1
CAS :<p>HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively.</p>Formule :C33H32ClN7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :626.11HDAC-IN-46
CAS :<p>HDAC-IN-46 inhibits HDAC1 & HDAC6, affects p-p38, Bcl-xL & cyclin D1, blocks G2 phase & induces apoptosis in TNBC research.</p>Formule :C22H30N8O2Couleur et forme :SolidMasse moléculaire :438.53SWS1
CAS :<p>SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating anti</p>Formule :C47H53ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :849.48PARP1-IN-14
CAS :<p>PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM.</p>Formule :C28H24FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.53RIPK1-IN-8
CAS :<p>RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseases</p>Formule :C26H24F2N6O3Couleur et forme :SolidMasse moléculaire :506.5AGN194204
CAS :<p>AGN194204 (IRX4204), an oral RXR agonist, inactive against RAR, has Kd 0.4-3.8 nM & EC50 0.08-0.8 nM, with anti-inflammatory and anticarcinogenic properties.</p>Formule :C24H32O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.51GP 1a
CAS :<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formule :C23H22Cl2N4ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :441.35JHU395
CAS :<p>JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.</p>Formule :C22H29N3O7Degré de pureté :99.15% - 99.26%Couleur et forme :SolidMasse moléculaire :447.48CDC801
CAS :<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formule :C23H24N2O5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :408.45ZNL 02-096
CAS :<p>ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar</p>Formule :C42H45N11O6Degré de pureté :99.02% - 99.84%Couleur et forme :SolidMasse moléculaire :799.88Ac-DEVD-CHO
CAS :<p>Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.</p>Formule :C20H30N4O11Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :502.47GCN2-IN-7
CAS :<p>GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.</p>Formule :C22H23BrN8OSDegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :527.44NSC697923
CAS :<p>NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.</p>Formule :C11H9NO5SDegré de pureté :97% - 99.71%Couleur et forme :SolidMasse moléculaire :267.26PARP1/2/TNKS1/2-IN-1
CAS :<p>PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.</p>Formule :C35H31FN6O5Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :634.66CDDO-2P-Im
CAS :<p>CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.</p>Formule :C39H46N4O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :618.81RH01386
CAS :<p>RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.</p>Formule :C18H15F3N4O3SDegré de pureté :99.16% - 99.67%Couleur et forme :SolidMasse moléculaire :424.4KSQ-4279
CAS :<p>KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,</p>Formule :C27H25F3N8ODegré de pureté :99.76% - 99.79%Couleur et forme :SoildMasse moléculaire :534.54Nanatinostat
CAS :<p>Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.</p>Formule :C20H19FN6O2Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :394.4DuP-697
CAS :<p>DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.</p>Formule :C17H12BrFO2S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :411.31PP5-IN-1
CAS :<p>PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.</p>Formule :C18H18N2O3SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :342.41Tefinostat
CAS :<p>Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.</p>Formule :C28H37N3O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :495.61MC4033
CAS :<p>MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].</p>Formule :C16H13N3O3Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :295.29AZA197
CAS :<p>AZA197 (AZA-197) is a selective Cdc42 inhibitor.</p>Formule :C24H36N6Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :408.58LB42708
CAS :<p>LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).</p>Formule :C30H27BrN4O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :555.47CPI-360
CAS :<p>CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.</p>Formule :C25H31N3O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :437.53Alrizomadlin
CAS :<p>Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.</p>Formule :C34H38Cl2FN3O4Degré de pureté :98.41% - 99.47%Couleur et forme :SolidMasse moléculaire :642.59VU0661013
CAS :<p>VU0661013 is an effective and selective inhibitor of MCL-1.</p>Formule :C39H39Cl2N5O4Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :712.66Elobixibat
CAS :<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Formule :C36H45N3O7S2Degré de pureté :97.43% - 98.03%Couleur et forme :SolidMasse moléculaire :695.89M3541
CAS :<p>M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.</p>Formule :C23H17FN6O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :428.42CDDO-3P-Im
CAS :<p>CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.</p>Formule :C39H46N4O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :618.81HM43239
CAS :<p>HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.</p>Formule :C29H33ClN6Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :501.07BRD-K44839765
CAS :<p>BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.</p>Formule :C23H19N3O2S2Couleur et forme :SolidMasse moléculaire :433.55BRD-K20733377
CAS :<p>BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.</p>Formule :C23H18N4O3SCouleur et forme :SolidMasse moléculaire :430.48HDAC-IN-81
CAS :<p>HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).</p>Formule :C20H27N3O3Couleur et forme :SolidMasse moléculaire :357.45CRT0066101
CAS :<p>CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7 nM and demonstrates anticancer effects [2].</p>Formule :C18H22N6OCouleur et forme :SolidMasse moléculaire :338.41DAPK1-IN-1
CAS :<p>DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.</p>Formule :C15H11BrO4Couleur et forme :SolidMasse moléculaire :335.15eIF4A3-IN-6
CAS :<p>eIF4A3-IN-6 is a potent eIF4A inhibitor, potentially used for treating eIF4A-related diseases like cancer. (US20170145026A1)</p>Formule :C26H25N3O5Couleur et forme :SolidMasse moléculaire :459.49Apoptosis inducer 5
<p>Apoptosis Inducer 5, a lignan enantiomer extracted from Crataegus pinnatifida, demonstrates cytotoxic properties through inducing apoptosis and autophagy in</p>Formule :C23H26O7Couleur et forme :SolidMasse moléculaire :414.45RET-IN-1
CAS :<p>RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).</p>Formule :C29H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.61Bayer-18
CAS :<p>Bayer-18 is an inhibitor of TYK2. It inhibits the viability of anaplastic large cell lymphoma cells, including K299, SR786, Mac1, and Mac2a, with an IC50 ranging from 2-3 µM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells.</p>Formule :C19H27FN6O2Couleur et forme :SolidMasse moléculaire :390.46Antiproliferative agent-4
<p>Antiproliferative agent-4 suppresses cancer cell growth with low toxicity, inhibits tumors in mice, and induces apoptosis in EC109 cells.</p>Formule :C29H35ClO8Couleur et forme :SolidMasse moléculaire :547.04PDEδ/NAMPT IN-1
CAS :<p>PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.</p>Formule :C26H30N4O4SCouleur et forme :SolidMasse moléculaire :494.61Tubulin inhibitor 13
CAS :<p>Tubulin inhibitor 13 (E27), IC50 16.1 μM, blocks tubulin polymerization, cancer cell migration, and invasion, induces apoptosis.</p>Formule :C25H21N3O4Couleur et forme :SolidMasse moléculaire :427.45PD-L1/HDAC6-IN-1
CAS :<p>PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.</p>Formule :C27H33N3O3Couleur et forme :SolidMasse moléculaire :447.569Sabialimon P
CAS :<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formule :C31H50O4Couleur et forme :SolidMasse moléculaire :486.73MG28
CAS :<p>MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.</p>Formule :C27H25NO3SCouleur et forme :SolidMasse moléculaire :443.56
