Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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PB28
CAS :<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Formule :C24H38N2OCouleur et forme :SolidMasse moléculaire :370.581Curzerene
CAS :<p>Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties.</p>Formule :C15H20ODegré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :216.32S-Adenosyl-L-methionine
CAS :<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44DTUN
<p>DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.</p>Couleur et forme :SolidOxybenzone-d3
<p>Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.</p>Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS :<p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>Formule :C56H81N13O10SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :1128.39EGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Degré de pureté :98%Couleur et forme :Odour SolidFerroptosis-IN-17
<p>Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.</p>Formule :C21H26N4O5SCouleur et forme :SolidMasse moléculaire :446.52ABBV-167
CAS :<p>ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.</p>Formule :C46H53ClN7O11PSCouleur et forme :SolidMasse moléculaire :978.45Thailanstatin D
CAS :<p>Thailanstatin D blocks AR-V7 splicing, disrupts U2AF65/SAP155 binding, and induces apoptosis in CRPC xenografts.</p>Formule :C28H41NO8Couleur et forme :SolidMasse moléculaire :519.635Enniatin A1
CAS :<p>Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).</p>Formule :C35H61N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.885TNF/IFNγ-IN-1
CAS :<p>TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.</p>Formule :C20H23N3O6Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :401.418-hydroxy Efavirenz
CAS :<p>8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.</p>Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.68Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS :<p>Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.</p>Formule :C25H35ClN4O9Couleur et forme :SolidMasse moléculaire :571.02PAA5
<p>PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.</p>Formule :C14H8Au5B2F8N2Couleur et forme :SolidMasse moléculaire :1348.66UZH1
CAS :<p>UZH1, a mix of active METTL3 inhibitor UZH1a (IC50 280 nM) and inactive UZH1b (IC50 28 μM), modifies epitranscriptomics and has antitumor properties.</p>Formule :C32H42N6O3Couleur et forme :SoildMasse moléculaire :558.71Thalidomide-5-NH-PEG2-NH2 hydrochloride
CAS :<p>Thalidomide-5-NH-PEG2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed to recruit CRBN proteins. It has the capability to be linked with target protein ligands via a linker, facilitating the formation of PROTAC molecules, such as THAL-SNS-032.</p>Formule :C19H25ClN4O6Couleur et forme :SolidMasse moléculaire :440.88Thalidomide-NH-PEG7
<p>Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.</p>Formule :C27H39N3O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.61HDAC3-IN-2
<p>HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.</p>Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37HC Toxin
CAS :<p>HC Toxin: cyclic tetrapeptide, reversible HDAC inhibitor (IC50=30 nM), upregulates 15-lipoxygenase-1, induces fetal hemoglobin, from C. carbonum.</p>Formule :C21H32N4O6Couleur et forme :SolidMasse moléculaire :436.509(E/Z)-Squalene
CAS :<p>(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.</p>Formule :C30H50Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :410.72SB-1295
<p>SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.</p>Formule :C23H22ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.88Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Formule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52SI-2
CAS :<p>SI-2, a SRC-3 inhibitor, triggers breast cancer cell death (IC50: 3-20 nM), sparing normal cells.</p>Formule :C15H15N5Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :265.31Mcl-1 inhibitor 14
<p>Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potential</p>Formule :C39H41ClFN5O5SCouleur et forme :SolidMasse moléculaire :746.29Eldecalcitol
CAS :<p>Eldecalcitol, orally active vitamin D analog, boosts bone density and treats osteoporosis.</p>Formule :C30H50O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.72Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Formule :C26H23N5OCouleur et forme :SolidMasse moléculaire :421.49LIB3S0280
<p>LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).</p>Couleur et forme :Odour SolidHDAC-IN-57
CAS :<p>HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4</p>Formule :C21H19N3O4Degré de pureté :98.38%Couleur et forme :SoildMasse moléculaire :377.39FW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Formule :C24H27N7OCouleur et forme :SolidMasse moléculaire :429.517Solanidine
CAS :<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>Formule :C27H43NODegré de pureté :96.83%Couleur et forme :SolidMasse moléculaire :397.64Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS :<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Formule :C17H19ClN4O6Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :410.81Apoptosis inducer 33
<p>Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.</p>Formule :C16H13N3O2Couleur et forme :SolidMasse moléculaire :279.293JAK/HDAC-IN-2
<p>JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.</p>Formule :C28H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.74-Epianhydrotetracycline hydrochloride
CAS :<p>EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.</p>Formule :C22H23ClN2O7Couleur et forme :SolidMasse moléculaire :462.88PK095
CAS :<p>PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.</p>Formule :C20H18N4O2SDegré de pureté :96.84%Couleur et forme :SoildMasse moléculaire :378.45SF1126
CAS :<p>SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.</p>Formule :C39H48N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :852.84GSK-3β inhibitor 15
<p>GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-</p>Formule :C17H16N6OSCouleur et forme :SolidMasse moléculaire :352.41Z-Asp-CH2-DCB
CAS :<p>Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.</p>Formule :C20H17Cl2NO7Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :454.26Vorsetuzumab
CAS :<p>Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.29%Couleur et forme :LiquidMasse moléculaire :146.1 kDaBIO8898
<p>BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.</p>Formule :C53H64N8O6Couleur et forme :SolidMasse moléculaire :909.132,2'-Dihydroxy chalcone
CAS :<p>2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.</p>Formule :C15H12O3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :240.25PROTAC GPX4 degrader-1
CAS :<p>PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080</p>Formule :C50H57ClN10O10Couleur et forme :SolidMasse moléculaire :993.5PROTAC Bcl-xL degrader-2
<p>PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.</p>Formule :C68H80N8O14S3Couleur et forme :SolidMasse moléculaire :1329.6HMGB1-IN-1
<p>HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/</p>Formule :C57H75N3O15Couleur et forme :SolidMasse moléculaire :1042.22VEGFR-2-IN-68
<p>VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.</p>Formule :C27H25N5O2SCouleur et forme :SolidMasse moléculaire :483.1729RMC-6291
CAS :<p>RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.</p>Formule :C55H78FN9O8Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :1012.26PRMT5-IN-31
<p>PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and</p>Formule :C21H24N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.43S65487 hydrochloride
CAS :<p>S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.</p>Formule :C41H42Cl2N6O4Couleur et forme :SolidMasse moléculaire :753.73Enterodiol
<p>Enterodiol is a natural product that can be used as a reference standard.</p>Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.37
