Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Bromoiodoacetamide
CAS :<p>Bromoiodoacetamide (I-HAcAm): cytotoxic, induces ROS & apoptosis in HepG-2 cells.</p>Formule :C2H3BrINOCouleur et forme :SolidMasse moléculaire :263.86iNOS/TopoI-IN-1
<p>Compound AuL9, also known as iNOS/TopoI-IN-1, is a multi-target hybrid molecule possessing anti-tumor, anti-inflammatory, and antioxidant properties. This compound effectively inhibits the growth of MCF-7 and MDA MB-231 breast cancer cells in vitro, exhibiting IC50 values of 3.5 μM and 6.3 μM respectively. It also prompts DNA damage and apoptosis in these cells by inhibiting human topoisomerase I (TopoI) with a K_i of 2.72 μM. Additionally, iNOS/TopoI-IN-1 reduces the expression of iNOS by suppressing the activation of NF-kB, with a K_i of 1.49 μM.</p>Formule :C34H40AuBrCl2N3OSCouleur et forme :SolidMasse moléculaire :886.54Uvarigrin
CAS :<p>Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.</p>Formule :C37H68O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.93Moracin N
CAS :<p>Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].</p>Formule :C19H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.34Antitumor agent-64
CAS :<p>Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells</p>Formule :C35H47N3O3SCouleur et forme :SolidMasse moléculaire :589.83IC 86621
CAS :<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25PROTAC Mcl1 degrader-1
CAS :<p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>Formule :C45H45BrN6O8SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :909.84Tubulin polymerization-IN-72
<p>Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.</p>Formule :C19H19FN4OCouleur et forme :SolidMasse moléculaire :338.379EGFR-IN-151
<p>EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.</p>Couleur et forme :Odour SolidNarasin (sodium salt)
CAS :<p>Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and</p>Formule :C43H71NaO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.01ATPase-IN-3
CAS :<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3β-Apopicropodophyllin
CAS :<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Formule :C22H20O7Couleur et forme :SolidMasse moléculaire :396.39Thalidomide-PEG2-NH2
CAS :<p>Thalidomide-PEG2-NH2: synthetic E3 ligase ligand-linker, combines Thalidomide-based cereblon and PROTAC linker.</p>Formule :C17H19N3O6Couleur et forme :SolidMasse moléculaire :361.354Anticancer agent 104
<p>Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis [1] .</p>Formule :C34H47F3N2O2S2Couleur et forme :SolidMasse moléculaire :636.87HX009
<p>HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).</p>Couleur et forme :Odour LiquidSiomycin A
CAS :<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>Formule :C71H81N19O18S5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1648.84Borrelidin
CAS :<p>Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.</p>Formule :C28H43NO6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :489.64Thalidomide-5-propargyne-NH2 hydrochloride
CAS :<p>Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.</p>Formule :C16H14ClN3O4Couleur et forme :SolidMasse moléculaire :347.753Carubicin
CAS :<p>Carubicin, an anthracycline antibiotic from Actinomadura carminata, disrupts DNA replication and repair by intercalating DNA and inhibiting topoisomerase II.</p>Formule :C26H27NO10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.49Fisetin quarterhydrate
<p>Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotective</p>Formule :C15H10O6H2OCouleur et forme :SolidMasse moléculaire :304.0583TNF-α-IN-6
CAS :<p>TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).</p>Formule :C26H25N9O2Couleur et forme :SolidMasse moléculaire :495.547Calcimycin hemicalcium salt
CAS :<p>Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.</p>Formule :C58H72CaN6O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1085.322(Rac)-AMXT-1501 4HCl
CAS :<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Formule :C32H72Cl4N6O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :714.77Tengonermin
CAS :<p>Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.</p>Couleur et forme :LiquidLenercept
CAS :<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Couleur et forme :LiquidMDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Formule :C25H24Cl2FN3O3Couleur et forme :SolidMasse moléculaire :504.38ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21Conglobatin
CAS :<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62KP1019
CAS :<p>KP1019 is now discontinued.</p>Formule :C21H19Cl4N6RuCouleur et forme :SolidMasse moléculaire :598.30(Rac)-BIO8898
CAS :<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Formule :C53H64N8O6Couleur et forme :SolidMasse moléculaire :909.13RIP2 Kinase Inhibitor 4
CAS :<p>RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.</p>Formule :C50H66F2N14O7SCouleur et forme :SolidMasse moléculaire :1045.23eIF4E-IN-3
CAS :<p>eIF4E-IN-3: potent eIF4e inhibitor with promise for cancer study.</p>Formule :C34H30ClF3N6O4SCouleur et forme :SolidMasse moléculaire :711.16TAS-117
CAS :<p>TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.</p>Formule :C26H24N4O2Couleur et forme :SolidMasse moléculaire :424.49Theophyllol
CAS :<p>Theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex.</p>Formule :C9H10N4Na2O4Couleur et forme :SolidMasse moléculaire :284.18Lesigercept
<p>Lesigercept is a humanized antibody that targets IGHE.</p>Couleur et forme :Odour LiquidBWA-522
<p>BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)</p>Formule :C43H51ClN4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.34Estradiol (cypionate)
CAS :<p>Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.</p>Formule :C26H36O3Degré de pureté :99.53% - >99.99%Couleur et forme :White Or Off-White Crystalline PowderMasse moléculaire :396.56p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
<p>p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.</p>Formule :C40H51Cl4N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :807.68Anti-inflammatory agent 95
<p>Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.</p>Formule :C16H21NO4Couleur et forme :SolidMasse moléculaire :291.34eIF4E-IN-1
CAS :<p>eIF4E-IN-1 inhibits eIF4E and boosts immunity by targeting PD-1, PD-L1, LAG3, TIM3, IDO, aiding cancer and infection treatment.</p>Formule :C33H28ClF3N6O4SCouleur et forme :SolidMasse moléculaire :697.13Tilogotamab
CAS :<p>Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).</p>Degré de pureté :95%Couleur et forme :LiquidERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Formule :C19H18BrN3O3SCouleur et forme :SolidMasse moléculaire :448.33CDK/HDAC-IN-4
<p>CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.</p>Couleur et forme :Odour SolidSchisandronic acid
CAS :<p>Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.</p>Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.68HDAC-IN-77
<p>HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.</p>Formule :C22H26N4O2SCouleur et forme :SolidMasse moléculaire :410.53Aspidin BB
CAS :<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.52R1-ICR-5
CAS :<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31Sorafenib-d4
CAS :<p>Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.</p>Formule :C21H16ClF3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.85WAY-118959-A
CAS :<p>WAY-118959-A is a potential microtubule acetylation inhibitor.</p>Formule :C16H14N4OS2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :342.44RET ligand-1
CAS :<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Formule :C28H24F2N6O3Couleur et forme :SolidMasse moléculaire :530.525
