ASK
Les inhibiteurs de la kinase régulatrice de l'apoptose (ASK) ciblent la famille des kinases ASK, qui sont des régulateurs critiques des voies de l'apoptose et de la réponse au stress. Les kinases ASK sont impliquées dans l'activation de l'apoptose en réponse à divers signaux de stress, y compris le stress oxydatif et les dommages à l'ADN. En inhibant ASK, ces composés peuvent moduler la signalisation apoptotique, offrant des outils précieux pour la recherche sur la mort cellulaire, le cancer et les maladies neurodégénératives. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de ASK de haute qualité pour soutenir vos recherches en apoptose, signalisation cellulaire et mécanismes des maladies.
9 produits trouvés pour "ASK"
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dASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Couleur et forme :Odour SoliddASK1
CAS :dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.Formule :C38H38F2N10O8Couleur et forme :SolidMasse moléculaire :800.77Anti-DBF4 Antibody (2Q22)
Anti-DBF4 Antibody (2Q22) is an antibody targeting DBF4. Anti-DBF4 Antibody (2Q22) can be used in ELISA, WB, IF Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200.Couleur et forme :Odour LiquidASK1-IN-1
CAS :ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formule :C19H19N9O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :405.41Ref: TM-T9697
1mg90,00€5mg215,00€10mg321,00€25mg582,00€50mg873,00€100mg1.216,00€1mL*10mM (DMSO)236,00€MSC 2032964A
CAS :MSC 2032964A: Potent, selective ASK1 inhibitor, IC50=93 nM, oral, brain-permeable, curbs neuroinflammation, blocks LPS-induced ASK1/p38 activation.
Formule :C16H13F3N6ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :362.31Ref: TM-T33514
1mg84,00€2mg97,00€5mg158,00€10mg240,00€25mg393,00€50mg560,00€100mg753,00€200mg1.035,00€CDK8/19-IN-1
CAS :CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formule :C19H18N4O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.5ASK1-IN-8
CAS :ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.Formule :C26H32N8O2Couleur et forme :SolidMasse moléculaire :488.585ASK1 ligand 1
CAS :ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Formule :C17H16F2N6OCouleur et forme :SolidMasse moléculaire :358.35ASK1-IN-7
CAS :ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formule :C13H8N2O2S2Couleur et forme :SolidMasse moléculaire :288.345
